Patents by Inventor QILEI ZHANG

QILEI ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240016763
    Abstract: Provided in the present invention are a coenzyme Q10 microemulsion, a preparation method therefor and the use thereof. The coenzyme Q10 microemulsion is prepared from components comprising coenzyme Q10, a carrier oil, an anti-crystallization agent, a lipophilic emulsifier, a hydrophilic emulsifier, a co-emulsifier and water. The microemulsion has a particle size DV(90) of between 20 nm and 80 nm, and is clear, transparent, free of demulsification and high in bioavailability, can be stably stored for a long time at normal temperatures and in extreme temperature environments. In addition, the microemulsion is suitable for the pharmaceutical, cosmetic and food fields, especially for beverages, oral liquids and other products. Also provided in the present invention is a method for preparing the coenzyme Q10 microemulsion, which is simple in equipment, low in cost and easy in operation.
    Type: Application
    Filed: March 24, 2022
    Publication date: January 18, 2024
    Inventors: Xiaoyong ZHU, Jiandong LI, Hongyue YAN, Zhirong CHEN, Jincheng CHENG, Qilei ZHANG, Wei LI, Tianqi LV, Guilai WANG
  • Publication number: 20230063291
    Abstract: A stable carotenoid microcapsule having high bioavailability and a preparation method therefor. The method includes the following steps: a) mixing carotenoid crystals with an organic solvent, and dissolving the mixture to obtain a carotenoid solution; b) introducing the carotenoid solution and a grease into a dispersion system to fully disperse carotenoid into the grease, and vaporizing the organic solvent to obtain a carotenoid-containing dispersion liquid; c) mixing the carotenoid-containing dispersion liquid and a protective colloid aqueous solution, and emulsifying the mixture to obtain an emulsion; and d) performing spray granulation and drying to obtain a carotenoid microcapsule.
    Type: Application
    Filed: April 29, 2021
    Publication date: March 2, 2023
    Inventors: Jiandong LI, Zhirong CHEN, Lifang SHI, Guodong HUANG, Lishuang PAN, Hong YIN, Dan QIU, Qilei ZHANG, Xiaoyong ZHU, Xiang LIU, Lidan QI
  • Patent number: 11034723
    Abstract: This invention relates to a hybrid ligand, a hybrid biomimetic chromedia and a preparing method and a use thereof, wherein the hybrid biomimetic chromedia takes hydrophilic porous microsphere as a substrate in chromatography, activated with allyl bromide and undergoing bromo-alcoholization with N-bromosuccinimide, then coupled with the hybrid ligands. The sequence of the hybrid ligand is phenylalanine-tyrosine-glutamine-5-aminobenzimidazole. The hybrid biomimetic chromedia has both of the two functional groups of phenylalanine-tyrosine-glutamine tripeptide and aminobenzimidazole, while maintaining the high antibody selectivity of polypeptide ligand, hydrophobic electric charge inductive ligand is introduced to achieve more moderate elution requirement, realizing effective antibody separation.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: June 15, 2021
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Shanjing Yao, Dongqiang Lin, Qilei Zhang, Xujun Zou, Huili Lu
  • Publication number: 20210009635
    Abstract: This invention relates to a hybrid ligand, a hybrid biomimetic chromedia and a preparing method and a use thereof, wherein the hybrid biomimetic chromedia takes hydrophilic porous microsphere as a substrate in chromatography, activated with allyl bromide and undergoing bromo-alcoholization with N-bromosuccinimide, then coupled with the hybrid ligands. The sequence of the hybrid ligand is phenylalanine-tyrosine-glutamine-5-aminobenzimidazole. The hybrid biomimetic chromedia has both of the two functional groups of phenylalanine-tyrosine-glutamine tripeptide and aminobenzimidazole, while maintaining the high antibody selectivity of polypeptide ligand, hydrophobic electric charge inductive ligand is introduced to achieve more moderate elution requirement, realizing effective antibody separation.
    Type: Application
    Filed: January 16, 2018
    Publication date: January 14, 2021
    Applicant: ZHEJIANG UNIVERSITY
    Inventors: Shanjing YAO, Dongqiang LIN, Qilei ZHANG, Xujun ZOU, Huili LU
  • Publication number: 20200029596
    Abstract: The present invention discloses a fat-soluble nutrient microcapsule and a preparation method thereof. The fat-soluble nutrient microcapsule comprises the following components in percentage by weight: a fat-soluble nutrient (0.2-51.6%), an antioxidant (0.2-5.0%), a wall material (41.4-97.6%) and a moisture (2.0-5.0%) and the ratio of the fat-soluble nutrient that keeps active in the fat-soluble nutrient microcapsule to the fat-soluble nutrient that is initially added is 0.990-0.997:1. The preparation method of the fat-soluble nutrient microcapsule comprises an emulsification process and a granulation process, wherein the emulsification is performed in a cavitation emulsifier. By the preparation method, the nutrient active substance of the fat-soluble nutrient microcapsule has less lost and high stability.
    Type: Application
    Filed: April 26, 2018
    Publication date: January 30, 2020
    Inventors: JIANDONG LI, BAISHAN HU, ZHIRONG CHEN, LIFANG SHI, QICHUAN LI, XIAOYONG ZHU, GUISHENG QIU, QILEI ZHANG, YOUMIN YANG, LINPU CAI