Abstract: The invention relates generally to articles (e.g., sensors) and methods that facilitate proteome, exome, or exome-codon sequence region wide interrogation for the discovery, screening and/or quantification of one or more proteins that contribute to a phenotype.

Abstract: Provided is a nanosensor having a high dynamic range and sensitivity for detecting the presence, and/or quantifying the amount, of an analyte in a sample of interest. Also provided is a cartridge incorporating the nanosensor, and a method and system for detecting the presence, and/or quantifying the amount, of the analyte in the sample of interest.

Abstract: The present invention generally relates, in some aspects, to articles and methods relating to nanosensors for determination of molecules and other features, e.g., via surface plasmonic resonance, electric resonance, magnetic resonance, color changes, or the like. These articles and methods may be used, for example, for sample detection. The articles described in some aspects of the invention include a microwell array and a nanosensor array. In some embodiments, The nanosensor arrays may utilize nanoparticles positioned on nanostructures that are able to interact with a sample suspected of containing an analyte, such as a single cell. The interaction between nanoparticles and a sample can be detected by a change in applied energy, such as altered electromagnetic radiation caused by surface plasmonic resonance of incident visible light, and/or other types of resonance.

Abstract: A miniature optical biosensor and biosensor array where high sensitivity for detection of biomolecular interaction does not require a fluorescent label. Non-linear frequency-shifts of optical resonators (‘nanobeams’) provide a digital all-or-nothing response to equilibrium binding of a biomarker to surface-immobilized bio-recognition elements, a signal suitable to identify active components in genetic and proteomic circuits, as well as toxic substances. The threshold level for the digital response is adjustable to accommodate for varying receptor affinities. A bistable cavity sensing (BCS) method can be used to track the shift of the resonance induced by the analyte more precisely than the conventional cavity sensing method, where the resolution is limited by the cavity linewidth. BCS method can be used to quantitate the concentration of the analyte, and their binding kinetics, affinities and etc.

Abstract: The present invention generally relates, in some aspects, to systems and methods for making and using sensors or other devices, such as optical components. One aspect is generally directed to a sensor or other device comprising a nanometer-sized portion. In some embodiments, the sensor can be used to determine various characteristics such as temperature, humidity, an electric field, a magnetic field, an analyte, or the like. For instance, in one embodiment, a portion of a sensor device may be inserted into a cell and used to study the cell, e.g., using optical techniques such as surface plasma resonance. In some embodiments, such sensors or other devices may comprise metal, glass, or other materials, which can be prepared using etching or other techniques.

Abstract: An on-chip integrated nanobeam cavity array spectrometer (INAS) having an array of waveguide-coupled nanobeam cavities. Waveguide splitters are used to bring the signal from the input waveguide into each cavity. The spectrum of unknown input signal is obtained by collecting signal from each nanobeam cavity in the array.

Abstract: A deterministic design and manufacturing of an ultrahigh Q-factor, wavelength-scale optical cavity is invented and experimentally demonstrated. The design can be implemented on photonic crystal nanobeam cavities, which are based on 1D optical waveguides. The waveguide has dielectric index alternations that provide constructive interference and produces optical resonance.

Abstract: An on-chip integrated nanobeam cavity array spectrometer (INAS) having an array of waveguide-coupled nanobeam cavities. Waveguide splitters are used to bring the signal from the input waveguide into each cavity. The spectrum of unknown input signal is obtained by collecting signal from each nanobeam cavity in the array.

Abstract: A miniature optical biosensor and biosensor array where high sensitivity for detection of biomolecular interaction does not require a fluorescent label. Non-linear frequency-shifts of optical resonators (‘nanobeams’) provide a digital all-or-nothing response to equilibrium binding of a biomarker to surface-immobilized bio-recognition elements, a signal suitable to identify active components in genetic and proteomic circuits, as well as toxic substances. The threshold level for the digital response is adjustable to accommodate for varying receptor affinities. A bistable cavity sensing (BCS) method can be used to track the shift of the resonance induced by the analyte more precisely than the conventional cavity sensing method, where the resolution is limited by the cavity linewidth. BCS method can be used to quantitate the concentration of the analyte, and their binding kinetics, affinities and etc.

Abstract: A deterministic design and manufacturing of an ultrahigh Q-factor, wavelength-scale optical cavity is invented and experimentally demonstrated. The design can be implemented on photonic crystal nanobeam cavities, which are based on 1D optical waveguides. The waveguide has dielectric index alternations that provide constructive interference and produces optical resonance.