Patents by Inventor Qimin Zhan

Qimin Zhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of two microRNA moleculars in lung cancer prognosis and medicine preparation
    Patent number: 8664191
    Abstract: The present invention relates to use of two microRNAs in detection of lung cancer prognosis and in medicine preparation. Particularly, the invention relates to a composition comprising two small RNA molecules microRNA-150 and microRNA-886-3p, a device comprising the composition used in detection of lung cancer prognosis and in preparation of medicaments for inhibiting mammal and human lung cancer metastasis. Specifically, the expression levels of microRNA-150 and microRNA-886-3p can be used as the prognostic criteria of lung cancer prognosis, wherein high expression level of the gene combination indicates favorable therapeutic effect. The invention also relates to a device detecting the expression levels of microRNA-150 and microRNA-886-3p in mammalian and human lung cancer and a method for detecting the expression levels of microRNA-150 and microRNA-886-3p in samples.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: March 4, 2014
    Assignee: Cancer Institute, Chinese Academy of Medical Services
    Inventors: Qimin Zhan, Lühua Wang, Nan Bi, Yongmei Song, Jianzhong Cao, Wenyang Liu
  • USE OF TWO MICRORNA MOLECULARS IN LUNG CANCER PROGNOSIS AND MEDICINE PREPARATION
    Publication number: 20120220644
    Abstract: The present invention relates to use of two microRNAs in detection of lung cancer prognosis and in medicine preparation. Particularly, the invention relates to a composition comprising two small RNA molecules microRNA-150 and microRNA-886-3p, a device comprising the composition used in detection of lung cancer prognosis and in preparation of medicaments for inhibiting mammal and human lung cancer metastasis. Specifically, the expression levels of microRNA-150 and microRNA-886-3p can be used as the prognostic criteria of lung cancer prognosis, wherein high expression level of the gene combination indicates favorable therapeutic effect. The invention also relates to a device detecting the expression levels of microRNA-150 and microRNA-886-3p in mammalian and human lung cancer and a method for detecting the expression levels of microRNA-150 and microRNA-886-3p in samples.
    Type: Application
    Filed: July 9, 2009
    Publication date: August 30, 2012
    Applicant: CANCER INSTITUTE, CHINESE ACADEMY OF MEDICAL SCIENCES
    Inventors: Qimin Zhan, Lühua Wang, Nan Bi, Yongmei Song, Jianzhong Cao, Wenyang Liu
  • Method of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Patent number: 7438892
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: October 21, 2008
    Assignee: The United States of Americas as represented by the Secretary of the Department of Health and Human Services
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jill D. Coursen, Qimin Zhan
  • Method of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Publication number: 20060280683
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Application
    Filed: August 17, 2006
    Publication date: December 14, 2006
    Applicant: The Government of the U.S, as represented by the Secretary of the Dept. of Health & Human Services
    Inventors: Xin Wang, Curtis Harris, Albert Fornace, Jill Coursen, Qimin Zhan
  • Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Patent number: 7125850
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: October 24, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Sevices
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jr., Jill D. Coursen, Qimin Zhan
  • Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Publication number: 20060088888
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Application
    Filed: December 7, 2005
    Publication date: April 27, 2006
    Applicants: Health and Human Services
    Inventors: Xin Wang, Curtis Harris, Albert Fornace, Jill Coursen, Qimin Zhan
  • Methods for identifying inhibitors of GADD45 polypeptide activity and inhibitors of such activity
    Patent number: 7005419
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: February 28, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jr., Jill D. Coursen, Qimin Zhan
  • Methods for identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Patent number: 6613318
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: September 2, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jr., Jill D. Coursen, Qimin Zhan