Patents by Inventor Qin Fu

Qin Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200292558
    Abstract: Described herein are methods for identification/discovery of protein biomarkers for chronic kidney disease (CKD) and diagnosing and/or prognosing and/or predicting progression of and/or treating chronic kidney disease (CKD).
    Type: Application
    Filed: October 12, 2018
    Publication date: September 17, 2020
    Applicants: Cedars-Sinai Medical Center, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jennifer VAN EYK, Qin FU, Vidya VENKATRAMAN, Zongming FU, Josef CORESH
  • Publication number: 20190369114
    Abstract: Sample preparation for proteomic analysis of complex biological samples by mass spectrometry is a tedious and time-consuming process with many steps where technical variations can be introduced and propagated. We describe an automated trypsin digestion workflow that yields uniformly-processed samples in less than 5 hours. Reproducible quantitation of hundreds of peptides from numerous proteins was seen across replicates, days, instruments, and laboratory sites, demonstrating the broad applicability of this approach.
    Type: Application
    Filed: July 18, 2019
    Publication date: December 5, 2019
    Applicant: Cedars-Sinai Medical Center
    Inventors: Jennifer VAN EYK, Qin FU, Vidya VENKATRAMAN, Irina TCHERNYSHYOV
  • Patent number: 10472400
    Abstract: A cardiac troponin I ultra-sensitive detection reagent kit, a preparation method, and a detection method. The reagent kit comprises at least one first anti-cardiac troponin I antibody marked with a trace marker and at least one second anti-cardiac troponin I antibody coated on magnetic microspheres, the first anti-cardiac troponin I antibody and cardiac troponin I binding site being different from the second anti-cardiac troponin I antibody and cardiac troponin I binding site. The reagent kit may further comprise a diluent capable of significantly reducing non-specific binding in a detection process, so as to further increase the detection accuracy and sensitivity. The method using the reagent kit to detect cardiac troponin I sensitively and accurately detects the amount of cardiac troponin I in a sample, and provides more timely and reliable information for the early diagnosis and treatment of AMI.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: November 12, 2019
    Assignee: SHENZHEN NEW INDUSTRIES BIOMEDICAL ENGINEERING CO., LTD
    Inventors: Wei Rao, Jinyun Yuan, Qin Li, Sheng Wang, Hong Xu, Wu Li, Tinghua Li, Jinqiu Fu
  • Patent number: 10352942
    Abstract: Described herein are methods for identifying signature peptides for quantifying a polypeptide of interest in a sample. The methods include cleaving the polypeptide into peptides; detecting a multiplicity of the peptides with a quantitative analytical instrument; comparing the linearity of signals attributable to pairs of the peptides in a multiplicity of samples; and selecting signature peptides from a group of peptides with more highly correlated signals.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: July 16, 2019
    Assignees: Cedars-Sinai Medical Center, The Johns Hopkins University
    Inventors: Eric Grote, Qin Fu, Jennifer Van Eyk, Vidya Venkatraman
  • Publication number: 20190211073
    Abstract: A synthesis method for low-racemization impurity liraglutide comprises the following steps: performing synthesis to obtain a propeptide, coupling 2 to 5 peptides comprising Thr-Phe on the propeptide by using a solid-phase synthesis method; further, performing solid-phase synthesis to obtain a liraglutide resin; the liraglutide resin is cracked after modification, or the liraglutide resin is directly cracked, purified and frozen dry, so as to obtain the liraglutide.
    Type: Application
    Filed: August 8, 2017
    Publication date: July 11, 2019
    Inventors: Yuqing FU, Hongji MA, Xinyu LI, Lixiang ZHANG, Qin ZHI, Lifen WU, Zicheng LIU
  • Publication number: 20180217162
    Abstract: The present invention relates to the field of myocardial injury. More specifically, the present invention provides methods and compositions useful in the diagnosis, prognosis and/or assessment of myocardial injury. In a specific embodiment, a method comprises the steps of (a) diagnosing a subject as having myocardial injury based on the statistically significant over expression of one or more markers described herein compared to a baseline value, wherein the markers are measured in a biological sample obtained from the subject; and (b) treating the subject with one or more of an anti-thrombolysis agent, coronary bypass surgery or angioplasty.
    Type: Application
    Filed: February 22, 2016
    Publication date: August 2, 2018
    Inventors: Qin Fu, Jennifer Eileen Van Eyk, Vidya Venkatraman
  • Publication number: 20180136220
    Abstract: Described herein are methods for identifying signature peptides for quantifying a polypeptide of interest in a sample. The methods include cleaving the polypeptide into peptides; detecting a multiplicity of the peptides with a quantitative analytical instrument; comparing the linearity of signals attributable to pairs of the peptides in a multiplicity of samples; and selecting signature peptides from a group of peptides with more highly correlated signals.
    Type: Application
    Filed: May 31, 2016
    Publication date: May 17, 2018
    Applicants: Cedars-Sinai Medical Center, The John Hopkins University
    Inventors: Eric GROTE, Qin FU, Jennifer Van Eyk, Vidya VENKATRAMAN
  • Patent number: 9434842
    Abstract: The invention relates to mix composition determination method of coarse graded high modulus asphalt concrete with skeleton embedded structure, which belongs to the road engineering design field. The invention use low labeled hard asphalt AH-30# with penetration degree no greater than 30 (0.1 mm); the nominal maximum aggregate size no smaller than 26.5 mm; building mineral aggregate gradation of the mix using course aggregate gap gradation; using gradation design method of asphalt mixture based on closest compact condition to select the optimal oil-stone ratio.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: September 6, 2016
    Assignees: RESEARCH INSTITUTE OF HIGHWAY, MOT, PRC, GUANGXI COMMUNICATIONS INVESTMENT GROUP CO., LTD., BEIJING MUNICIPAL ROAD & BRIDGE BUILDING MATERIAL GROUP CO., LTD.
    Inventors: Xudong Wang, Qin Fu, Xingye Zhou, Zhijie Chen, Lei Zhang, Hao Liu, Chaoyang Guo, Qian Xiao
  • Patent number: 9039994
    Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: May 26, 2015
    Assignee: The Johns Hopkins University
    Inventors: Jennifer Van Eyk, Simon Sheng, Qin Fu
  • Patent number: 8985895
    Abstract: An auxiliary member for pavement construction, including: a cylinder, a base plate and a leveling bolt; the cylinder includes a first cylinder part and a second cylinder part which are connected and communicated with each other, the first cylinder part is provided with a sling installing member and a slurry inlet, bottom of the second cylinder part is connected with the base plate, the base plate is provided with a bolt extending hole and multiple slurry discharging holes which are communicated with the inner cavity of the second cylinder part, the leveling bolt includes a bolt head and a screw, the screw extends through the bolt extending hole, the bolt head is arranged in the second cylinder part and the bolt head is smaller than the inner diameter of the second cylinder part. The present invention further provides a concrete slab and a method for pavement construction.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: March 24, 2015
    Assignees: Research Institute of Highway Ministry of Transport, Zhonglu High-Tech Highway Technology (Beijing) Co., Ltd., Guangxi Communications Investment Group Co., Ltd.
    Inventors: Bo Tian, Qin Fu, Zhijie Chen, Jinde Xie, Peng Peng, Zuguang Yuan, Zhi Fu, Zhu Luo, Ying Liu, Rongguo Hou, Dapeng Wang, Jiliang Wang, Hongfeng Sun, Xiuxiong Mo, Zhe He
  • Publication number: 20140257742
    Abstract: The invention involves “a method to structure mineral aggregate gradation by using three control points & two curves”, including the following steps: (1) Three control points are determined according to the property of the mixtures: nominal maximum size of aggregate and its passing rate, nominal minimum size of aggregate and its passing rate, and the discontinuity point between the coarse aggregate and the fine aggregate and its passing rate. (2) The grading curves of the coarse and the fine aggregate are selected respectively with Power function model, Exponential function model and Logarithmic function model. (3) Measure the stamped density and the stamped voids in mineral aggregate, and then choose the grading of the coarse and the fine aggregate on the basis of the project need. The invention can help constitute different gradation curves in line with local materials from different areas and sources.
    Type: Application
    Filed: October 15, 2012
    Publication date: September 11, 2014
    Applicants: RESEARCH INSTITUTE OF HIGHWAY, MOT, PRC, GUANGXI COMMUNICATIONS INVESTMENT GROUP CO., LTD.
    Inventors: Xudong Wang, Qin Fu, Lei Zhang, Yi Liu, Xingye Zhou, Fujian Li
  • Publication number: 20140245925
    Abstract: The invention relates to ‘mix composition determination method of coarse graded high modulus asphalt concrete with skeleton embedded structure’, which belongs to the road engineering design field. The invention use low labeled hard asphalt AH-30# with penetration degree no greater than 30 (0.1 mm); the nominal maximum aggregate size no smaller than 26.5 mm; building mineral aggregate gradation of the mix by the idea of course aggregate gap gradation; using gradation design method of asphalt mixture based on closest compact condition to select the optimal oil-stone ratio.
    Type: Application
    Filed: October 16, 2012
    Publication date: September 4, 2014
    Inventors: Xudong Wang, Qin Fu, Xingye Zhou, Zhijie Chen, Lei Zhang, Hao Liu, Chaoyang Guo, Qian Xiao
  • Publication number: 20140186852
    Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.
    Type: Application
    Filed: July 29, 2013
    Publication date: July 3, 2014
    Applicant: The Johns Hopkins University
    Inventors: Jennifer Van Eyk, Simon Sheng, Qin Fu
  • Publication number: 20140147203
    Abstract: An auxiliary member for pavement construction, including: a cylinder, a base plate and a leveling bolt; the cylinder includes a first cylinder part and a second cylinder part which are connected and communicated with each other, the first cylinder part is provided with a sling installing member and a slurry inlet, bottom of the second cylinder part is connected with the base plate, the base plate is provided with a bolt extending hole and multiple slurry discharging holes which are communicated with the inner cavity of the second cylinder part, the leveling bolt includes a bolt head and a screw, the screw extends through the bolt extending hole, the bolt head is arranged in the second cylinder part and the bolt head is smaller than the inner diameter of the second cylinder part. The present invention further provides a concrete slab and a method for pavement construction.
    Type: Application
    Filed: February 3, 2014
    Publication date: May 29, 2014
    Applicants: RESEARCH INSTITUTE OF HIGHWAY MINISTRY OF TRANSPORT, GUANGXI COMMUNICATIONS INVESTMENT GROUP CO., LTD., ZHONGLU HIGH-TECH HIGHWAY TECHNOLOGY (BEIJING) CO., LTD.
    Inventors: Bo Tian, Qin Fu, Zhijie Chen, Jinde Xie, Peng Peng, Zuguang Yuan, Zhi Fu, Zhu Luo, Ying Liu, Rongguo Hou, Dapeng Wang, Jiliang Wang, Hongfeng Sun, Xiuxiong Mo, Zhe He
  • Patent number: 8497078
    Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: July 30, 2013
    Assignee: The Johns Hopkins University
    Inventors: Jennifer Van Eyk, Simon Sheng, Qin Fu
  • Publication number: 20120009174
    Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.
    Type: Application
    Filed: May 26, 2009
    Publication date: January 12, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jennifer Van Eyk, Simon Sheng, Qin Fu
  • Publication number: 20040101510
    Abstract: We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with PARC. We found that specific cytokines were suppressed by PARC. PARC can be used to treat diseases such as cancer, autoimmune diseases, rheumatoid arthritis, myeloproliferative disorders, and coronary artery disease, which are characterized by too much mitosis.
    Type: Application
    Filed: September 12, 2003
    Publication date: May 27, 2004
    Applicant: Molecular Staging Inc.
    Inventors: Qin Fu, Velizar T. Tchernev, Ebenezer Satyaraj, Dhavalkumar D. Patel, Stephen F. Kingsmore
  • Publication number: 20040009503
    Abstract: Human extracellular ribonucleases (RNases) are widely distributed in various organs and body fluids and together with other members of the mammalian RNase A superfamily. In addition to their RNase activity, several RNases have been shown to have special biological actions, i.e., antitumor, antiviral and angiogenic properties. However, the molecular mechanisms of such activities are unclear. Using protein microarrays amplified rolling circle amplification (RCA), we investigated the effects of EDN (Rnase 2), ECP (Rnase 3) and RNase 1 on leukocytes cytokine production. We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with different combinations of RNases and RNase inhibitors.
    Type: Application
    Filed: March 26, 2003
    Publication date: January 15, 2004
    Applicant: Molecular Staging, Inc.
    Inventors: Qin Fu, Velizar Tchernev, Ebenezer Satyaraj, Dhavalkumar D. Patel, Stephen F. Kingsmore, Barry Schweitzer