Abstract: The present invention relates to the field of biomedicine, and relates to a pharmaceutical use of a hypoxia-inducible lipid droplet-associated protein or a truncated fragment thereof. Specifically, the present invention relates to a use of a hypoxia-inducible lipid droplet-associated protein or a truncated active fragment thereof in the preparation of a drug for treating or preventing hyperlipidemia, hyperlipidemia complications or neurodegenerative diseases, or a use of the hypoxia-inducible lipid droplet-associated protein or the truncated active fragment thereof in the preparation of a drug for reducing the apolipoprotein level, low-density lipoprotein level, or very low-density lipoprotein level in blood or cerebrospinal fluid.

Abstract: A method and device for optimizing regulation of reservoir sediment discharging, comprises: determining a relation curve between a dam front water depth and a reservoir capacity; determining a time length by which a sediment peak is propagated to the front of a dam and a time length by which the sediment peak lags behind a flood peak at the front of the dam based on the relation curve and the hydrologic features; determining another relation curve between a sediment peak attenuation rate and a sediment concentration of the sediment peak, and a time length by which the sediment peak subjected to a man-made flood wave is propagated to the front of the dam; and acquiring a real-time sediment concentration, and generating the man-made flood wave based on the time length by which the sediment peak is propagated to the front of the dam and the another relation curve.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may disconnect from a first radio access technology (RAT) service, independent of signaling from the first RAT service, after sensing that the UE has entered a coverage hole. The UE may use a connection to a second RAT service while in the coverage hole in association with disconnecting from the first RAT service. The UE may disconnect from the second RAT service, independent of signaling from the second RAT service, after sensing that the UE has exited the coverage hole and before expiration of a radio link failure (RLF) timer for the second RAT service. The UE may reconnect to the first RAT service before expiration of an RLF timer for the first RAT service. Numerous other aspects are described.

Abstract: A method for forming a semiconductor structure in provided. The method includes providing a substrate, forming a gate electrode layer on the substrate, and performing a defluorination treatment on the gate electrode layer. The method also includes, after performing the defluorination treatment, forming a barrier layer on a portion of a surface of the gate electrode layer. The barrier layer is made of a material including titanium element.

Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: Provided is a pyrimidine derivative, a preparation method and a use thereof, wherein the pyrimidine derivative is selected from a compound represented by Formula (I), or a tautomer, an enantiomer, a diastereomer, a mesomer, a racemate, or a mixture thereof, or a pharmaceutically acceptable salt or prodrug thereof. The pyrimidine derivative shows an excellent CDK-inhibiting effect and action.

Abstract: A heat-resistant H1N1 subtype influenza virus mutant strain rPR8-HA-N5 has been preserved at China Center for Type Culture Collection, Wuhan University, Wuhan, China with the preservation number of CCTCC No. V202043.

Abstract: Provided is a lateral water intake structure for preventing silting of bed load and floating debris, which is provided at a river bank. The lateral water intake structure includes: a diversion canal, a guiding wall structure, a shaft-shaped water intaking space, and a trash rack. The lateral water intake structure functions to prevent the floating debris from gathering at the surface of the trash rack and reduce a risk that the trash rack is damaged by water pressure and hitting of the floating debris. Meanwhile, by using a water flow in the watercourse to continuously wash the floating debris near the trash rack, maintenance costs of removing the floating debris at the trash rack manually or mechanically can be reduced.

Abstract: A heat-resistant H1N1 subtype influenza virus mutant strain rPR8-HA-N5 has been preserved at China Center for Type Culture Collection, Wuhan University, Wuhan, China with the preservation number of CCTCC No. V202043.

Abstract: A heat-resistant recombinant Newcastle Disease Virus vaccine strain rLS-tFib2-C capable of expressing truncated Fiber 2 protein of fowl adenovirus serotype 4 has been preserved at the China Center for Type Culture Collection, Wuhan University, Wuhan, China with the preservation number of CCTCC No. V202042.

Abstract: Provided is a lateral water intake structure for preventing silting of bed load and floating debris, which is provided at a river bank. The lateral water intake structure includes: a diversion canal, a guiding wall structure, a shaft-shaped water intaking space, and a trash rack. The lateral water intake structure functions to prevent the floating debris from gathering at the surface of the trash rack and reduce a risk that the trash rack is damaged by water pressure and hitting of the floating debris. Meanwhile, by using a water flow in the watercourse to continuously wash the floating debris near the trash rack, maintenance costs of removing the floating debris at the trash rack manually or mechanically can be reduced.

Abstract: A heat-resistant recombinant Newcastle Disease Virus vaccine strain rLS-tFib2-C capable of expressing truncated Fiber 2 protein of fowl adenovirus serotype 4 has been preserved at the China Center for Type Culture Collection, Wuhan University, Wuhan, China with the preservation number of CCTCC No. V202042.

Abstract: The present invention discloses a near-infrared regenerative intelligent fiber-based adsorptive material and a preparation method and use thereof. The material is obtained by chemically grafting a stepwise dual-temperature stimuli-responsive polyethyleneimine onto a carboxylated cellulose nanofiber matrix to prepare a stepwise dual-temperature stimuli-responsive intelligent nanofiber, and combining the stepwise dual-temperature stimuli-responsive intelligent nanofiber with a photosensitizer having near-infrared stimuli-response to prepare a stepwise dual-temperature/near-infrared stimuli-responsive intelligent nanofiber, and then by using a crosslinking agent to directly crosslink and combine the stepwise dual-temperature/near-infrared stimuli-responsive intelligent nanofiber with a hyperbranched polyamine in one step. The material has a stepwise dual-temperature/near-infrared stimuli-response, high density of amino group (greater than 14 mmol/g), and nano cavities.

Abstract: Oil or gas fields and associated facilities are computer simulated by solving linear algebraic equations using a Schwarz method with at least one well node included in the overlap. According to another aspect, equations for the wellbore nodes are processed to eliminate some non-pressure variables, e.g. component compositions. Other features are also provided.

Abstract: Systems and methods for determining operating settings for a fluid production system that includes wells and a processing facility, the method including identifying at least one swing well and one or more non-swing wells and determining at least one target parameter equation that is a function of at least one processing facility constraint and one or more non-swing well parameters. The method further includes incorporating the target parameter equation into a fully-coupled equation set representing the production system, simulating the production system using the fully-coupled equation set to obtain one or more operating settings that meet the processing facility constraint, and presenting to a user the operating settings.

Abstract: In some embodiments, systems, methods, and articles may operate to compute, in parallel, to determine values of unknowns in network equations associated with a network of sub-surface wells and at least one surface facility, for intra-well subdivisions of the network, and then for inter-well subdivisions of the network, wherein the computing is based on default values of the unknowns, or prior determined values of the unknowns. Additional activities may include constructing a distributed Jacobian matrix having portions comprising coefficients of the unknowns distributed among a number of processors, wherein each of the portions is distributed to a particular one of the processors previously assigned to corresponding ones of the subdivisions. The Jacobian matrix may be factored to provide factors and eliminate some of the unknowns. Back-solving is used to determine remaining unsolved ones of the unknowns, using the factors. Additional apparatus, systems, and methods are described.

Abstract: A locking device includes a lock, a blade and an attachment. The lock includes a key slot and a lockpin unit. The key slot extends from a key insertion face to an interior of the lock. The lock includes an inner wall. The lockpin unit is in the lock and extends into the key slot from the inner wall of the lock. The blade includes a guiding end, a control end, a receiving portion located between the guiding and control ends, and a guiding piece. The guiding piece is arranged at the guiding end. The guiding end is located in the key slot, and the control end is located outside the key slot. The attachment is detachably attached to the receiving portion. The blade is slid to drive the attachment to be in or off contact with the lockpin unit.

Abstract: Foamed pressure-sensitive adhesive tape having outstanding flame retardancy values and also very good technical adhesive properties comprising a foamed layer and an outer pressure sensitive adhesive layer wherein the outer pressure sensitive adhesive layer comprises at least 10 wt % of flame retardant and the foamed layer comprises less than 10 wt % of flame retardant or none, based in each case on the total weight of the layer in question.

Abstract: A locking device includes a lock, a blade and an attachment. The lock includes a key slot and a lockpin unit. The key slot extends from a key insertion face to an interior of the lock. The lock includes an inner wall. The lockpin unit is in the lock and extends into the key slot from the inner wall of the lock. The blade includes a guiding end, a control end, a receiving portion located between the guiding and control ends, and a guiding piece. The guiding piece is arranged at the guiding end. The guiding end is located in the key slot, and the control end is located outside the key slot. The attachment is detachably attached to the receiving portion. The blade is slid to drive the attachment to be in or off contact with the lockpin unit.

Abstract: A system architecture is disclosed that includes a privacy management system. In particular, the privacy management system provides a policy hub for maintaining and managing customer privacy information. The privacy management system maintains a master data database for customer information and customer privacy preferences, and a rules database for privacy rules. The privacy management system captures, synchronizes, and stores customer privacy data. Privacy rules may be authored using a privacy management vocabulary, and can be customized for an enterprise's privacy policies.