Abstract: Provided is a pyrimidine derivative, a preparation method and a use thereof, wherein the pyrimidine derivative is selected from a compound represented by Formula (I), or a tautomer, an enantiomer, a diastereomer, a mesomer, a racemate, or a mixture thereof, or a pharmaceutically acceptable salt or prodrug thereof. The pyrimidine derivative shows an excellent CDK-inhibiting effect and action.

Abstract: Some implementations of the disclosed systems, apparatus, methods and computer program products are configured automatically generating service plans using large language models (LLMs).

Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: A method and device for optimizing regulation of reservoir sediment discharging, comprises: determining a relation curve between a dam front water depth and a reservoir capacity; determining a time length by which a sediment peak is propagated to the front of a dam and a time length by which the sediment peak lags behind a flood peak at the front of the dam based on the relation curve and the hydrologic features; determining another relation curve between a sediment peak attenuation rate and a sediment concentration of the sediment peak, and a time length by which the sediment peak subjected to a man-made flood wave is propagated to the front of the dam; and acquiring a real-time sediment concentration, and generating the man-made flood wave based on the time length by which the sediment peak is propagated to the front of the dam and the another relation curve.

Abstract: A computing services environment may include a database system storing database records for client organizations accessing computing services including a conversational chat interface, an application server providing access to the conversational chat interface, a metadata repository storing metadata entries characterizing a actions capable of being performed via the computing services environment, and an orchestration service configured to execute an orchestration process based on a natural language request message received via the conversational chat interface. An input prompt including the natural language request message and descriptions of actions selected from the metadata entries may be determined and transmitted to a generative language model. A prompt completion including a plan that includes a subset of the actions and a natural language description of the plan may be received from the generative language model and sent to a client machine via the conversational chat interface.

Abstract: Implementations claimed and described herein provide systems and methods for optimizing well completion modeling. The systems and methods use an AI-driven modeling system with a plurality of different machine-learning components.

Abstract: The present application provide a compound represented by formula (I), a chiral enantiomer thereof or a pharmaceutically acceptable salt thereof, and a preparation method therefor, an intermediate for preparing the compound represented by formula (I), the chiral enantiomer thereof or the pharmaceutically acceptable salt thereof, and a preparation method therefor, a pharmaceutical composition comprising the compound represented by formula (I), the chiral enantiomer thereof or the pharmaceutically acceptable salt thereof, and pharmaceutical use of the compound represented by formula (I), the chiral enantiomer thereof or the pharmaceutically acceptable salt thereof or the pharmaceutical composition comprising the same. The compounds of the present application exhibit good JAK2 kinase inhibitory activity and high selectivity for JAK2 kinase.

Abstract: A method and device for optimizing regulation of reservoir sediment discharging, comprises: determining a relation curve between a dam front water depth and a reservoir capacity; determining a time length by which a sediment peak is propagated to the front of a dam and a time length by which the sediment peak lags behind a flood peak at the front of the dam based on the relation curve and the hydrologic features; determining another relation curve between a sediment peak attenuation rate and a sediment concentration of the sediment peak, and a time length by which the sediment peak subjected to a man-made flood wave is propagated to the front of the dam; and acquiring a real-time sediment concentration, and generating the man-made flood wave based on the time length by which the sediment peak is propagated to the front of the dam and the another relation curve.

Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: Provided is a pyrimidine derivative, a preparation method and a use thereof, wherein the pyrimidine derivative is selected from a compound represented by Formula (I), or a tautomer, an enantiomer, a diastereomer, a mesomer, a racemate, or a mixture thereof, or a pharmaceutically acceptable salt or prodrug thereof. The pyrimidine derivative shows an excellent CDK-inhibiting effect and action.

Abstract: A heat-resistant H1N1 subtype influenza virus mutant strain rPR8-HA-N5 has been preserved at China Center for Type Culture Collection, Wuhan University, Wuhan, China with the preservation number of CCTCC No. V202043.

Abstract: Provided is a lateral water intake structure for preventing silting of bed load and floating debris, which is provided at a river bank. The lateral water intake structure includes: a diversion canal, a guiding wall structure, a shaft-shaped water intaking space, and a trash rack. The lateral water intake structure functions to prevent the floating debris from gathering at the surface of the trash rack and reduce a risk that the trash rack is damaged by water pressure and hitting of the floating debris. Meanwhile, by using a water flow in the watercourse to continuously wash the floating debris near the trash rack, maintenance costs of removing the floating debris at the trash rack manually or mechanically can be reduced.

Abstract: A heat-resistant H1N1 subtype influenza virus mutant strain rPR8-HA-N5 has been preserved at China Center for Type Culture Collection, Wuhan University, Wuhan, China with the preservation number of CCTCC No. V202043.

Abstract: A heat-resistant recombinant Newcastle Disease Virus vaccine strain rLS-tFib2-C capable of expressing truncated Fiber 2 protein of fowl adenovirus serotype 4 has been preserved at the China Center for Type Culture Collection, Wuhan University, Wuhan, China with the preservation number of CCTCC No. V202042.

Abstract: Provided is a lateral water intake structure for preventing silting of bed load and floating debris, which is provided at a river bank. The lateral water intake structure includes: a diversion canal, a guiding wall structure, a shaft-shaped water intaking space, and a trash rack. The lateral water intake structure functions to prevent the floating debris from gathering at the surface of the trash rack and reduce a risk that the trash rack is damaged by water pressure and hitting of the floating debris. Meanwhile, by using a water flow in the watercourse to continuously wash the floating debris near the trash rack, maintenance costs of removing the floating debris at the trash rack manually or mechanically can be reduced.

Abstract: A heat-resistant recombinant Newcastle Disease Virus vaccine strain rLS-tFib2-C capable of expressing truncated Fiber 2 protein of fowl adenovirus serotype 4 has been preserved at the China Center for Type Culture Collection, Wuhan University, Wuhan, China with the preservation number of CCTCC No. V202042.

Abstract: The present invention discloses a near-infrared regenerative intelligent fiber-based adsorptive material and a preparation method and use thereof. The material is obtained by chemically grafting a stepwise dual-temperature stimuli-responsive polyethyleneimine onto a carboxylated cellulose nanofiber matrix to prepare a stepwise dual-temperature stimuli-responsive intelligent nanofiber, and combining the stepwise dual-temperature stimuli-responsive intelligent nanofiber with a photosensitizer having near-infrared stimuli-response to prepare a stepwise dual-temperature/near-infrared stimuli-responsive intelligent nanofiber, and then by using a crosslinking agent to directly crosslink and combine the stepwise dual-temperature/near-infrared stimuli-responsive intelligent nanofiber with a hyperbranched polyamine in one step. The material has a stepwise dual-temperature/near-infrared stimuli-response, high density of amino group (greater than 14 mmol/g), and nano cavities.

Abstract: Oil or gas fields and associated facilities are computer simulated by solving linear algebraic equations using a Schwarz method with at least one well node included in the overlap. According to another aspect, equations for the wellbore nodes are processed to eliminate some non-pressure variables, e.g. component compositions. Other features are also provided.

Abstract: Systems and methods for determining operating settings for a fluid production system that includes wells and a processing facility, the method including identifying at least one swing well and one or more non-swing wells and determining at least one target parameter equation that is a function of at least one processing facility constraint and one or more non-swing well parameters. The method further includes incorporating the target parameter equation into a fully-coupled equation set representing the production system, simulating the production system using the fully-coupled equation set to obtain one or more operating settings that meet the processing facility constraint, and presenting to a user the operating settings.

Abstract: In some embodiments, systems, methods, and articles may operate to compute, in parallel, to determine values of unknowns in network equations associated with a network of sub-surface wells and at least one surface facility, for intra-well subdivisions of the network, and then for inter-well subdivisions of the network, wherein the computing is based on default values of the unknowns, or prior determined values of the unknowns. Additional activities may include constructing a distributed Jacobian matrix having portions comprising coefficients of the unknowns distributed among a number of processors, wherein each of the portions is distributed to a particular one of the processors previously assigned to corresponding ones of the subdivisions. The Jacobian matrix may be factored to provide factors and eliminate some of the unknowns. Back-solving is used to determine remaining unsolved ones of the unknowns, using the factors. Additional apparatus, systems, and methods are described.