Abstract: Aspects of the present disclosure are directed to methods, compositions, and kits for detection and analysis of DNA and RNA cytosine methylation. Certain aspects include methods, compositions and kits useful in bisulfite sequencing of methylated nucleic acids, including methylated nucleic acids from low-input samples such as cell-free DNA and cell-free RNA. Also disclosed are methods and compositions for detection and quantification of 5-hydroxymethylcytosine in DNA.

Abstract: Various illustrative aspects are directed to a data storage device, comprising one or more disks; an actuator mechanism configured to position one or more heads proximate to a corresponding disk surface of the one or more disks; and one or more processing devices. The one or more processing devices are configured to receive signals indicative of conditions of a write operation by the selected head. The one or more processing devices are further configured to determine, based on the signals, a verification status indicating whether the write operation was successful. The one or more processing devices are further configured to output the verification status within a selected time limit.

Abstract: A method for enhancing characteristic signals by synthesizing multiple frequency waves is provided, which includes: obtaining real frequency responses based on the measurement results of spectral signals; selecting complex frequencies to at least partially compensate for spectral line broadening caused by losses; and obtaining complex frequency responses based on multiple real frequency responses and the selected complex frequencies to enhance the characteristic signals.

Abstract: A display base plate includes sub-pixels, substrate, pixel defining layer disposed on side of substrate which includes first, second and third retaining wall; first and second retaining wall configured to form opening area of sub-pixel, first retaining wall is located between opening areas of adjacent sub-pixels having different colors, second retaining wall is located between opening areas of adjacent sub-pixels having same color; third retaining wall is disposed at side of first retaining wall facing away from substrate, and orthographic projection of third retaining wall on substrate is located within range of orthographic projection of first retaining wall on substrate; surface of side of first retaining wall away from substrate is higher than surface of side of second retaining wall away from substrate, and is lower than a surface of side third retaining wall away from substrate.

Abstract: The present disclosure provides display base plate, preparation method thereof and display device. The display base plate includes plurality of sub-pixels, substrate, and pixel defining layer disposed on side of the substrate, the pixel defining layer is configured for forming opening area of the sub-pixel, and the opening area has long edge and short edge; the plurality of sub-pixels include first sub-pixel and second sub-pixel having the same color and adjacent to each other, the opening area of the first sub-pixel is first opening area having first long edge, the opening area of the second sub-pixel is second opening area having first short edge; the first long edge is at least partially adjacent to the first short edge, height of the pixel defining layer located between the first opening area and second opening area is at least less than that of at least portion of some other pixel defining layers.

Abstract: The invention provides a plasmon enhanced infrared spectrum sensor for detecting a protein secondary structure in an aqueous solution and a preparation method of the plasmon enhanced infrared spectrum sensor, and belongs to the technical field of infrared optical sensing. The sensor includes a graphene plasmon chip and a micro-fluidic system compatible with infrared transmission testing. Under excitation of incident infrared light, a locally enhanced electromagnetic field (surface plasmon) is formed on the surface of the graphene layer due to collective oscillation of charges, and molecules to be detected in an aqueous solution are enriched in a surface plasmon region due to Van der Waals interaction of the graphene layer.

Abstract: A HAMR data storage device may include a magnetic media and a slider comprising: a main pole, a waveguide, and a near-field transducer (NFT) situated between the main pole and the waveguide, wherein an air-bearing surface (ABS) of the slider comprises a transparent overcoat layer situated over the main pole, the waveguide, and the NFT, and wherein the transparent overcoat layer has a particular thickness such that, during an operational phase of the HAMR data storage device, a gap between a media-facing surface of the transparent overcoat layer and the magnetic media is less than about 0.5 nm.

Abstract: A HAMR data storage device may include a magnetic media and a slider comprising: a main pole, a waveguide, and a near-field transducer (NFT) situated between the main pole and the waveguide, wherein an air-bearing surface (ABS) of the slider comprises a transparent overcoat layer situated over the main pole, the waveguide, and the NFT, and wherein the transparent overcoat layer has a particular thickness such that, during an operational phase of the HAMR data storage device, a gap between a media-facing surface of the transparent overcoat layer and the magnetic media is less than about 0.5 nm.

Abstract: Provided is a display panel, including: a substrate; a pixel definition layer having at least one strip-shaped first opening therein, wherein the first opening includes an expansion region and a contraction region that are alternately arranged along a first direction, and a size of the expansion region in a second direction is larger than a size of the expansion region in the second direction; a plurality of first partition walls, disposed in the first opening, wherein each of the first partition walls extends along the second direction, and two ends of the first partition wall are respectively in contact with two side walls of the first opening to partition the first opening into a plurality of pixel openings; and a plurality of light-emitting portions, respectively disposed in the plurality of pixel openings; wherein a height of the first partition wall is less than a height of the pixel definition layer.

Abstract: A data processing system implements obtaining presentation content for a presentation, the presentation content including a set of slides and a transcript. The system further implements obtaining presentation style information for the presentation from a presentation datastore, generating a prompt for a LLM that includes the transcript and the presentation style information to cause the first LLM to generate an augmented transcript by rewriting the textual cues of the first transcript into a conversational style associated with the presentation style identified in the presentation style information; generating audiovisual content by generating speech for a virtual presenter and generating audiovisual content synchronizing an animation of the virtual presenter with the first audio content, and sending the audiovisual content to the computing devices of users who are in an audience of the presentation.

Abstract: Provided is an array substrate, comprising a plurality of opening regions. The array substrate further comprises a substrate and at least one functional layer stacked on one side of the substrate. The functional layer comprises a plurality of functional patterns and at least one supplementary pattern, the plurality of functional patterns are configured to transmit electrical signals, and there is a gas region between the plurality of functional patterns; the at least one supplementary pattern is at least provided in at least one opening region, and the supplementary pattern is located in the gap region between the plurality of functional patterns. The plurality of functional patterns and the at least one supplementary pattern are spaced apart, and the plurality of functional patterns and the at least one supplementary pattern are arranged at substantially equal intervals.

Abstract: Various illustrative aspects are directed to a data storage device, comprising one or more disks; an actuator system configured to position a selected head among one or more heads proximate to a corresponding disk surface among the one or more disks; and one or more processing devices. The selected head comprises a write element, an assistive energy emitter, an energizing interface coupled to the assistive energy emitter, and a detector. The assistive energy emitter is driven separately from driving of the write element. The one or more processing devices are configured to detect, via the detector, an energy anomaly at the energizing interface; detect, in response to detecting the energy anomaly, whether a previously written track yields an anomalous readback signal; and rewrite, in response to detecting that the previously written track yields an anomalous readback signal, data designated for the previously written track to the previously written track.

Abstract: Provided is a display panel, including: a substrate including a display region and a packaging region surrounding the display region; and a cluster-shaped barrier structure surrounding the display region and disposed on a surface of the packaging region, wherein the cluster-shaped barrier structure includes a plurality of barrier strips, and a length extending direction of each barrier strip is intersected with an extending direction of an edge line of the display region.

Abstract: Various illustrative aspects are directed to a data storage device, comprising one or more disks; an actuator mechanism configured to position one or more heads proximate to a corresponding disk surface of the one or more disks; and one or more processing devices. The one or more processing devices are configured to receive signals indicative of conditions of a write operation by the selected head. The one or more processing devices are further configured to determine, based on the signals, a verification status indicating whether the write operation was successful. The one or more processing devices are further configured to output the verification status within a selected time limit.

Abstract: Provided is a display panel. The display panel includes: a substrate; a plurality of pixels, disposed on a side of the substrate, wherein each of the plurality of pixels includes a plurality of sub-pixels of different colors; a pixel definition layer, disposed on the side of the substrate, wherein the pixel definition layer includes a plurality of first openings sequentially arranged in a first direction and a plurality of second openings disposed within the plurality of first openings and sequentially arranged in a second direction; a drainage layer, disposed on a side, distal from the substrate, of the pixel definition layer, wherein the drainage layer includes a plurality of drainage portions spaced apart from each other.

Abstract: Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-? receptor II (dnTGF?RII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Abstract: A display panel is provided. A pixel defining layer of the display panel includes a first defining layer and a second defining layer, wherein the first defining layer includes a first base body and first magnets dispersed in the first base body, and the second defining layer includes a second base body and second magnets dispersed in the second base body; both the first base body and the second base body are hydrophobic and elastic; and a side face of the first base body perpendicular to a bearing surface of the substrate and a side face of the second base body perpendicular to the bearing surface of the substrate being in contact with each other.

Abstract: This disclosure relates to the field of display technologies, and discloses a display substrate, a method for fabricating the same, and a display device. The display substrate includes: a substrate, and a plurality of pixels and a pixel definition layer on the substrate, wherein the pixels include long sides and short sides; and the pixel definition layer includes long-side sections adjacent to the long sides, and short-side sections adjacent to the short sides, wherein heights of the long-side sections are greater than heights of the short-side sections.

Abstract: A computer system is provided. The computer system includes a memory, a user interface, and a processor coupled to the memory and the user interface. The at least one processor is configured to render, via the user interface, a first representation of the computer system and a second representation of a remote computer system distinct from the computer system; receive, via the user interface, input initiating a drag-and-drop operation of a digital resource provided by the remote computer system; detect entry of a cursor effectuating the drag-and-drop operation into the first representation; confine the cursor to a portion of the first representation; move a target proxy window to encompass the portion of the first representation; and free the cursor to continue effectuation of the drag-and-drop operation.