Patents by Inventor Qing Dong

Qing Dong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLOPYRIMIDONE OR PYRROLOTRIAZONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATIONS THEREOF
    Publication number: 20180244679
    Abstract: Methods of preparation and pharmaceutical uses of pyrazolopyrimidone derivatives are described. Specifically, methods of preparation and pharmaceutical uses of pyrazolopyrimidone derivatives represented by the general formula (II) and pharmaceutically acceptable salts thereof are described, wherein the definitions of substituents in the general formula (II) are the same as the definitions in the specification. The pyrazolopyrimidone derivatives are useful as gonadotropin releasing hormone (GnRH) antagonists, such as for therapeutic agents for endometriosis.
    Type: Application
    Filed: May 2, 2018
    Publication date: August 30, 2018
    Inventors: Hejun LU, Piaoyang SUN, Bin GUI, Qing DONG
  • PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF
    Publication number: 20180222912
    Abstract: A pyrrole six-membered heteroaryl ring derivative, and the medicinal uses thereof are described. Specifically, the pyrrole six-membered heteroaryl ring derivative is a compound of formula (I), wherein the variable groups are as described in the specification.
    Type: Application
    Filed: March 22, 2018
    Publication date: August 9, 2018
    Inventors: Xuejun ZHANG, Qing DONG, Bonian LIU, Yaoping ZHU, Xiaotao LI, Jiong LAN
  • Pyrazolopyrimidone or pyrrolotriazone derivatives, method of preparing same, and pharmaceutical applications thereof
    Patent number: 10005781
    Abstract: Pyrazolopyrimidone and pyrrolotriazone derivatives, methods of preparation thereof, and pharmaceutical uses thereof are described. Specifically, pyrazolopyrimidone and pyrrolotriazone derivatives represented by the general formula (I) and pharmaceutically acceptable salts thereof are described. The pyrazolopyrimidone and pyrrolotriazone derivatives are useful as gonadotropin releasing hormone (GnRH) antagonists, such as for therapeutic agents for endometriosis. The definitions of the substituents in the general formula (I) are the same as the definitions in the specification.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: June 26, 2018
    Assignees: Shanghai Hengrui Pharmaceutical Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Hejun Lu, Piaoyang Sun, Bin Gui, Qing Dong
  • 3D print apparatus and method utilizing friction stir welding
    Patent number: 9987707
    Abstract: This invention discloses a 3D printing apparatus and method utilizing friction stir welding (FSW). The apparatus includes a material feeding mechanism, a control mechanism, a friction stir welding (FSW) mechanism, and a friction stir welding (FSW) rotation drive mechanism. The control mechanism controls the material feeding mechanism, the FSW mechanism and the FSW rotation drive mechanism. In addition to the control mechanism, the FSW mechanism also connects to the FSW rotation drive mechanism. The method comprises the steps of: 1, start the control mechanism; step 2, the control mechanism controls the material feeding mechanism to feed filling material; step 3, print 3D product with FSW mechanism. The invention achieves additive manufacturing and 3D printing with a new friction stir welding technology.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: June 5, 2018
    Inventors: Xiao Dong, Qing Dong
  • FUSED HETEROAROMATIC PYRROLIDINONES
    Publication number: 20180141951
    Abstract: Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L1, L2, R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.
    Type: Application
    Filed: August 21, 2017
    Publication date: May 24, 2018
    Inventors: Yasuyoshi Arikawa, Benjamin Jones, Betty Lam, Masashi Takahashi, Christopher Smith, Qing Dong, Victoria Feher, Zhe Nie
  • IMIDAZO ISOINDOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
    Publication number: 20180118750
    Abstract: The present invention relates to an imidazo isoindole derivative, a preparation method therefor and a medical use thereof. In particular, the present invention relates to the imidazo isoindole derivative as shown in the formula (I), a preparation method and pharmaceutical composition containing the derivative, and a use thereof for treating diseases with a pathological characteristic of the IDO-mediated tryptophan metabolic pathways. The diseases comprise cancers, Alzheimer's disease, autoimmune diseases, depression, anxiety disorders, cataracts, psychological disorders and AIDS, wherein the substituents in the formula (I) are the same as those defined in the specification.
    Type: Application
    Filed: April 12, 2016
    Publication date: May 3, 2018
    Applicants: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Wangyang TU, Guoji XU, Haitang ZHANG, Jiangtao CHI, Qing DONG
  • INTRAOCULAR PRESSURE SENSOR
    Publication number: 20180098696
    Abstract: An intraocular pressure sensor is presented that achieve very low power consumption. The intraocular pressure sensor takes the form of an implantable assembly configured to be implanted in an eye of a subject. Specifically, the implantable assembly is comprised of a capsular tension ring attached to a flexible printed circuit board. The flexible printed circuit board includes a cutout that is sized to encircle the pupil of the eye and is C shaped. One or more electrical components are also mounted onto the flexible printed circuit board. One such component is a voltage reference generator that is implemented by a circuit which provides inherently low process variation and low power consumption.
    Type: Application
    Filed: December 13, 2017
    Publication date: April 12, 2018
    Inventors: David T. BLAAUW, Zhiyoong FOO, Gyouho KIM, Qing DONG, Dennis SYLVESTER
  • 3D Print Apparatus and Method Utilizing Friction Stir Welding
    Publication number: 20180050418
    Abstract: This invention discloses a 3D printing apparatus and method utilizing friction stir welding (FSW). The apparatus includes a material feeding mechanism, a control mechanism, a friction stir welding (FSW) mechanism, and a friction stir welding (FSW) rotation drive mechanism. The control mechanism controls the material feeding mechanism, the FSW mechanism and the FSW rotation drive mechanism. In addition to the control mechanism, the FSW mechanism also connects to the FSW rotation drive mechanism. The method comprises the steps of: 1, start the control mechanism; step 2, the control mechanism controls the material feeding mechanism to feed filling material; step 3, print 3D product with FSW mechanism. The invention achieves additive manufacturing and 3D printing with a new friction stir welding technology.
    Type: Application
    Filed: October 4, 2016
    Publication date: February 22, 2018
    Inventors: Xiao Dong, Qing Dong
  • Methods of treating androgen receptor-mediated disorders with imidazoline derivatives
    Patent number: 9895355
    Abstract: Methods for treating androgen receptor-mediated diseases, such as breast cancer, with imidazoline derivatives of formula (I) are provided:
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: February 20, 2018
    Assignees: Shanghai Hengru Pharmaceutical Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Hejun Lu, Piaoyang Sun, Hongbo Fei, Hongjian Jiang, Haowei Wang, Qing Dong
  • CHARGE PUMP
    Publication number: 20180026530
    Abstract: In a charge pump circuit, a first circuit is configured to provide a first node with a first first-voltage level or a first second-voltage level. A second circuit is configured to provide a second node with a second first-voltage level or a second second-voltage level. The first node is coupled with a first end of a first capacitive element. The second node is coupled with a first end of a second capacitive element. A first end of a first voltage transfer circuit is configured to receive an input voltage. A second end of the first voltage transfer circuit is coupled with a second end of the first capacitive element and a first end of a second voltage transfer circuit. A second end of the second voltage transfer circuit is coupled with a second end of the second capacitive element, and is configured to provide an output voltage.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 25, 2018
    Inventors: Qing DONG, Tien-Chun YANG, Yue-Der CHIH
  • Variation-Tolerant Voltage Reference
    Publication number: 20170357285
    Abstract: A sub-nW voltage reference is presented that provides inherently low process variation and enables trim-free operation for low-dropout regulators and other applications in nW microsystems. Sixty chips from three different wafers in 180 nm CMOS are measured, showing an untrimmed within-wafer ?/? of 0.26% and wafer-to-wafer ?/? of 1.9%. Measurement results also show a temperature coefficient of 48-124 ppm/° C. from ?40° C. to 85° C. Outputting a 0.986V reference voltage, the reference operates down to 1.2V and consumes 114 pW at 25° C.
    Type: Application
    Filed: June 14, 2017
    Publication date: December 14, 2017
    Inventors: Qing DONG, David T. BLAAUW, Dennis SYLVESTER
  • PYRIDINECARBOXAMIDE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USES THEREOF
    Publication number: 20170342059
    Abstract: Pyridinecarboxamide derivatives, preparation methods, and a pharmaceutical uses thereof are provided. In particular, pyridinecarboxamide derivatives represented by general formula (I), wherein the substituents of the formula (I) are defined in the specification are provided. Also provided are a preparation method for the pyridinecarboxamide derivatives of formula (I), a pharmaceutical composition containing the pyridinecarboxamide derivatives, and uses of the pyridinecarboxamide derivatives as therapeutic agents, especially as inhibitors of the Renal Outer Medullary Potassium channel (ROMK) and in the preparation of medicaments for treating and/or preventing hypertension and heart failure.
    Type: Application
    Filed: November 10, 2015
    Publication date: November 30, 2017
    Inventors: Xin LI, Qing DONG, Piaoyang SUN
  • Charge pump
    Patent number: 9787176
    Abstract: In a charge pump circuit, a first circuit is configured to provide a first node with a first first-voltage level or a first second-voltage level. A second circuit is configured to provide a second node with a second first-voltage level or a second second-voltage level. The first node is coupled with a first end of the first capacitive element. The second node is coupled with a first end of the second capacitive device. A first end of the first voltage transfer circuit is configured to receive an input voltage. A second end of the first voltage transfer circuit is coupled with a second end of the first capacitive device and a first end of the second voltage transfer circuit. A second end of the second voltage transfer circuit is coupled with a second end of the second capacitive element.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: October 10, 2017
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.
    Inventors: Qing Dong, Tien-Chun Yang, Yue-Der Chih
  • METHODS OF TREATING ANDROGEN RECEPTOR-MEDIATED DISORDERS WITH IMIDAZOLINE DERIVATIVES
    Publication number: 20170128422
    Abstract: Methods for treating androgen receptor-mediated diseases, such as breast cancer, with imidazoline derivatives of formula (I) are provided:
    Type: Application
    Filed: January 20, 2017
    Publication date: May 11, 2017
    Inventors: Hejun LU, Piaoyang SUN, Hongbo FEI, Hongjian JIANG, Haowei WANG, Qing DONG
  • Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof
    Patent number: 9637484
    Abstract: Cycloalkyl acid derivatives, a preparation method thereof, and a pharmaceutical application thereof are described. In particular, a cycloalkyl acid derivative represented by general formula (I) and a medical salt thereof, a preparation method thereof, and an application of the cycloalkyl acid derivative and the medical salt thereof as URAT1 inhibitors, and particularly as therapeutic agents for diseases related to an abnormal uric acid level are described, wherein definitions of substituent groups in general formula (I) are the same as the definitions in the specification.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: May 2, 2017
    Assignees: SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD., JIANGSU HENGRUI MEDICINE CO., LTD.
    Inventors: Jianbiao Peng, Piaoyang Sun, Jiong Lan, Chunyan Gu, Xiaotao Li, Bonian Liu, Chunzhou Han, Qiyue Hu, Fangfang Jin, Qing Dong, Guoqing Cao
  • Imidazoline derivatives, preparation methods thereof, and their applications in medicine
    Patent number: 9586947
    Abstract: New imidazoline derivatives represented by formula (I): preparation methods thereof, pharmaceutical compositions comprising such derivatives, and applications of such derivatives in preparing androgen receptor antagonists and medicaments for treating diseases such as prostate cancer are described.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: March 7, 2017
    Assignees: Shanghai Hengrui Pharmaceutical Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Hejun Lu, Piaoyang Sun, Hongbo Fei, Hongjian Jiang, Haowei Wang, Qing Dong
  • COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE
    Publication number: 20170044171
    Abstract: Intermediate compounds used in the preparation of pyrrole six-membered heteroaryl ring derivatives are disclosed. In particular, compounds of formula (IB) are disclosed. The compounds of formula (IB) are used in the synthesis of Janus kinase (JAK) inhibitors. Substituents in formula (IB) have the same definitions as in the description.
    Type: Application
    Filed: November 1, 2016
    Publication date: February 16, 2017
    Inventors: Xuejun ZHANG, Qing DONG, Bonian LIU, Yaoping ZHU, Xiaotao LI, Jiong LAN
  • AMIDE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND MEDICINAL APPLICATION THEREOF
    Publication number: 20170037044
    Abstract: Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof are provided. Specifically, amide derivatives represented by general formula (I) are provided. The amide derivatives represented by general formula (I) can be used as a therapeutic agent, particularly as an inhibitor for microsomal prostaglandin E synthase-1 (mPGES-1), and also to treat and/or prevent diseases or illnesses such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.
    Type: Application
    Filed: March 31, 2015
    Publication date: February 9, 2017
    Applicants: Shanghai Hengrui Pharmaceutical Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Xin LI, Wei HE, Xianbo LIU, Bin WANG, Qiyue HU, Fangfang JIN, Qing DONG, Piaoyang SUN
  • Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof
    Patent number: 9527851
    Abstract: The present invention relates to a pyrrole six-membered heteroaryl ring derivative, the preparation method therefor, and the medicinal uses thereof. Specifically, the present invention relates to a new pyrrole six-membered heteroaryl ring derivative as represented by formula (I), the preparation method therefor, a medicinal composition comprising the derivative, and a therapeutic method using same, and, in particular, the uses as a JAK inhibitor and an immunosuppressor. Substituents in formula (I) have the same definitions as in the description.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: December 27, 2016
    Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Xuejun Zhang, Qing Dong, Bonian Liu, Yaoping Zhu, Xiaotao Li, Jiong Lan
  • CHARGE PUMP
    Publication number: 20160268893
    Abstract: In a charge pump circuit, a first circuit is configured to provide a first node with a first first-voltage level or a first second-voltage level. A second circuit is configured to provide a second node with a second first-voltage level or a second second-voltage level. The first node is coupled with a first end of the first capacitive element. The second node is coupled with a first end of the second capacitive device. A first end of the first voltage transfer circuit is configured to receive an input voltage. A second end of the first voltage transfer circuit is coupled with a second end of the first capacitive device and a first end of the second voltage transfer circuit. A second end of the second voltage transfer circuit is coupled with a second end of the second capacitive element.
    Type: Application
    Filed: February 10, 2016
    Publication date: September 15, 2016
    Inventors: Qing DONG, Tien-Chun YANG, Yue-Der CHIH