Patents by Inventor Qing Dou

Qing Dou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (-)-Epigallocatechin gallate derivatives for inhibiting proteasome
    Publication number: 20060041010
    Abstract: (?)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (?)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formula 10, wherein R1 is selected from the group of —H and C1 to C6 acyl group; R2, R3, and R4 are each independently selected from the group of —H, —OH, and C1 to C6 acyloxyl group; and at least one of R2, R3, or R4 is —H. The derivatives of (?)-EGCG that is at least as potent as (?)-EGCG. The carboxylate protected forms of (?)-EGCG and its derivatives are found to be more stable than the unprotected forms, which can be used as proteasome inhibitors to reduce tumor cell growth.
    Type: Application
    Filed: August 19, 2004
    Publication date: February 23, 2006
    Applicants: The Hong Kong Polytechnic University, Wayne State University, Moffitt Cancer Center
    Inventors: Tak-Hang Chan, Wai-Har Lam, Larry Chow, Qing Dou, Deborah Kuhn, Aslamuzzaman Kazi