Patents by Inventor Qing Jing

Qing Jing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule compound composition that efficiently induces differentiation of human pluripotent stem cells into myocardial cells
    Patent number: 11788060
    Abstract: Disclosed is a small molecule compound composition that efficiently induces the differentiation of human pluripotent stem cells into myocardial cells. In particular, provided in the present invention is a small molecule compound composition. The small molecule compound composition comprises the following components: (i) an mTOR signaling pathway inhibitor; (ii) a Wnt pathway promoter; and (iii) optionally, a pharmaceutically acceptable carrier. The small molecule compound composition in the present invention can efficiently induce the differentiation of human pluripotent stem cells into myocardial cells. The preliminarily screened cardiomyocyte differentiation rate reaches up to 86%, and the optimized cardiomyocyte differentiation rate reaches up to 98.3%.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: October 17, 2023
    Assignee: Shanghai Institutes for Biological Sciences Chinese Academy of Sciences
    Inventors: Qing Jing, Xiaoxu Qui, Yang Liu, Yifan Zhang
  • Mammalian and Bacterial Nitric Oxide Synthase Inhibitors
    Publication number: 20200331910
    Abstract: Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity of nitric oxide synthases (NOSs), the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with NOS activity.
    Type: Application
    Filed: June 26, 2020
    Publication date: October 22, 2020
    Inventors: Richard B. Silverman, Heng-Yen Wang, Yajuan Qin, Fengwei Zou, Soo Sung Kang, Qing Jing
  • Mammalian and bacterial nitric oxide synthase inhibitors
    Patent number: 10759791
    Abstract: Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity of nitric oxide synthases (NOSs), the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with NOS activity.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 1, 2020
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Heng-Yen Wang, Yajuan Qin, Fengwei Zou, Soo Sung Kang, Qing Jing
  • SMALL MOLECULE COMPOUND COMPOSITION THAT EFFICIENTLY INDUCES DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO MYOCARDIAL CELLS
    Publication number: 20190032016
    Abstract: Disclosed is a small molecule compound composition that efficiently induces the differentiation of human pluripotent stem cells into myocardial cells. In particular, provided in the present invention is a small molecule compound composition. The small molecule compound composition comprises the following components: (i) an mTOR signaling pathway inhibitor; (ii) a Wnt pathway promoter; and (iii) optionally, a pharmaceutically acceptable carrier. The small molecule compound composition in the present invention can efficiently induce the differentiation of human pluripotent stem cells into myocardial cells. The preliminarily screened cardiomyocyte differentiation rate reaches up to 86%, and the optimized cardiomyocyte differentiation rate reaches up to 98.3%.
    Type: Application
    Filed: January 12, 2017
    Publication date: January 31, 2019
    Applicant: SHANGAHI INSTITUTES FOR BIOLOGICAL SCIENCES CHINESE ACADEMY OF SCIENCES
    Inventors: Qing JING, Xiaoxu QUI, Yang LIU, ZHANG Yifan
  • 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
    Patent number: 10167260
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: January 1, 2019
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • Mammalian and bacterial nitric oxide synthase inhibitors
    Patent number: 9951014
    Abstract: Compounds and related methods for inhibition of mammalian and bacterial nitric oxide synthase.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: April 24, 2018
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing, Soosung Kang, Heng-Yen Wang
  • 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20170298021
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 19, 2017
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • Mammalian and Bacterial Nitric Oxide Synthase Inhibitors
    Publication number: 20170275278
    Abstract: Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity of nitric oxide synthases (NOSs), the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with NOS activity.
    Type: Application
    Filed: April 7, 2017
    Publication date: September 28, 2017
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Heng-Yen Wang, Yajuan Qin, Fengwei Zou, Soo Sung Kang, Qing Jing
  • 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
    Patent number: 9732037
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: August 15, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors
    Patent number: 9682950
    Abstract: Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: June 20, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, He Huang, Qing Jing
  • 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20160347713
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Application
    Filed: August 15, 2016
    Publication date: December 1, 2016
    Inventors: Richard B. Silverman, Qing Jing
  • 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
    Patent number: 9416106
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: August 16, 2016
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20160152590
    Abstract: Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
    Type: Application
    Filed: January 25, 2016
    Publication date: June 2, 2016
    Inventors: Richard B. Silverman, He Huang, Qing Jing
  • Mammalian and Bacterial Nitric Oxide Synthase Inhibitors
    Publication number: 20160122302
    Abstract: Compounds and related methods for inhibition of mammalian and bacterial nitric oxide synthase.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 5, 2016
    Inventors: Richard B. Silverman, Qing Jing, Soosung Kang, Heng-Yen Wang
  • Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors
    Patent number: 9242957
    Abstract: Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: January 26, 2016
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, He Huang, Qing Jing
  • 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20150368201
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Application
    Filed: August 31, 2015
    Publication date: December 24, 2015
    Inventors: Richard B. Silverman, Qing Jing
  • 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
    Patent number: 9120750
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: September 1, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20140256016
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 11, 2014
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors
    Publication number: 20140256958
    Abstract: Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 11, 2014
    Inventors: Richard B. Silverman, He Huang, Qing Jing
  • Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors
    Patent number: 8735606
    Abstract: Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 27, 2014
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, He Huang, Qing Jing