Abstract: The present invention relates to the field of pharmaceutical and chemical engineering, and specifically relates to a weakly acidic microenvironment-sensitive aptamer for tumors, a triptolide conjugate. The conjugate is formed by conjugation between the 14-position hydroxyl group of triptolide and the aptamer via an acetal ester linking bond, which is an acid-sensitive linking bond with a cleavage condition of (pH=3.5-6.5), which is much less pH-sensitive and is more likely to cleave under the tumor microenvironment. Based on the characteristics of the aptamer targeting the highly expressed proteins on the membrane surface of tumor cells, the conjugate delivered triptolide targeted to tumor cells and mediated endocytosis to reach the lysosome; based on the characteristics of the acidic environment of lysosomes, the acetal ester linking bond released intact triptolide in the lysosomal acidic environment, targeting and killing of tumor cells.

Abstract: A client device displays a user interface, which includes a menu item associated with forced reminders. In response to a user selecting the menu item, the client device displays a forced-reminder user interface, which includes a content display area configured to display one or more forced-reminder messages.

Abstract: The present application provides a method and apparatus for centralized management of personnel and equipment based on an instant messaging application. The method may include determining a device bound to a preset community; adding information of the device to an organizational architecture of the preset community, so that when a community member of the preset community views an organizational architecture in the instant messaging application, the information of the device is presented in the organizational architecture. Through the technical solution of the present application, the information of the device may be added and presented in the organizational architecture of the community, so as to uniformly manage the members and the devices in the community.

Abstract: The present application provides an instant messaging-based secure voice communication method and means. The method comprises: receiving a user-issued secure communication instruction to conduct voice communications with at least one opposite terminal in a secure communication mode; establishing a voice communication connection with at least one opposite terminal according to the secure communication instruction; prohibiting, during voice communications with at least one opposite terminal, the occurrence of risky operations detrimental to the security of the voice communications. By providing a secure communication mode, the present application solves the security problems of voice communications in instant messaging contexts and improves the security of instant messaging.

Abstract: A client device displays a user interface, which includes a menu item associated with forced reminders. In response to a user selecting the menu item, the client device displays a forced-reminder user interface, which includes a content display area configured to display one or more forced-reminder messages.

Abstract: A client device displays a user interface, which includes a menu item associated with forced reminders. In response to a user selecting the menu item, the client device displays a forced-reminder user interface, which includes a content display area configured to display one or more forced-reminder messages.

Abstract: The present application provides a method and apparatus for centralized management of personnel and equipment based on an instant messaging application. The method may include determining a device bound to a preset community; adding information of the device to an organizational architecture of the preset community, so that when a community member of the preset community views an organizational architecture in the instant messaging application, the information of the device is presented in the organizational architecture. Through the technical solution of the present application, the information of the device may be added and presented in the organizational architecture of the community, so as to uniformly manage the members and the devices in the community.

Abstract: A method and apparatus for user status reminders in video communication, wherein the method may include: during a video communication procedure between a current user and another user, detecting, by monitoring, an intervening communication event; and sending a reminder message regarding the intervening communication event to the other user, the reminder message being operative to instruct as to whether the current user has a need to respond to the intervening communication event. Through technical solutions of the present disclosure, users participating in video communication may comprehend mutual status change conditions at any time, facilitating performing timely adjustments to the procedure and content of the video communication.

Abstract: A prompting method and apparatus are disclosed. The method includes: detecting a communication event; and when a preset trigger event for switching the communication event from an execution state to a termination state is monitored, executing a preset prompting operation on a local communication party to prompt the local communication party to send a reminder related to the communication event to an opposite communication party. By adoption of the technical solutions of the present application, a user can be helped to execute a sending operation of the reminder.

Abstract: A relationship prompting method may include detecting a communication event; determining relationship data between a requester user and a responder user or an associated user corresponding to the responder user of the communication event; and pushing the relationship data to the responder user such that the relationship data is displayed in an associated device of the responder user. By using the technical solution of the present disclosure, a relationship prompt is provided for a user in a communication process, helping the user infer the communication intent of the other party and helping improve the communication efficiency.

Abstract: The present application provides an instant messaging-based secure voice communication method and means. The method comprises: receiving a user-issued secure communication instruction to conduct voice communications with at least one opposite terminal in a secure communication mode; establishing a voice communication connection with at least one opposite terminal according to the secure communication instruction; prohibiting, during voice communications with at least one opposite terminal, the occurrence of risky operations detrimental to the security of the voice communications. By providing a secure communication mode, the present application solves the security problems of voice communications in instant messaging contexts and improves the security of instant messaging.

Abstract: The present invention provides an apparatus and method for microdissecting a biological sample. In particular, apparatuses of the invention include a cell collecting device 100 that is operated by a pneumatic device 200. In one particular embodiment, apparatuses of the invention are used for collecting and transferring cell sample to and from cell collecting device 100.

Abstract: The present invention relates to a method for preparing the sustained-release tablets via direct compression process, wet granulation process or dry granulation process to obtain the formulations. The present invention also provides a use of the sustained-release tablet formulation of pramipexole in the preparation of pharmaceutical compositions. A sustained release tablet formulation has advantages as follows: breaking out patent monopoly of the innovator preparation, drug dissolution release effects in vitro can be achieved and probably clinical treatment effects can also be accomplished consistent with that of the innovator preparation; abandoning anionic polymers used in the innovator preparation such that making the drug release and absorption not being influenced by the patent body's gastric pH values, in order to avoid the disadvantages of the innovator preparation.

Abstract: A client device displays a user interface, which includes a menu item associated with forced reminders. In response to a user selecting the menu item, the client device displays a forced-reminder user interface, which includes a content display area configured to display one or more forced-reminder messages.

Abstract: The present invention relates to a method for preparing the sustained-release tablets via direct compression process, wet granulation process or dry granulation process to obtain the formulations. The present invention also provides a use of the sustained-release tablet formulation of pramipexole in the preparation of pharmaceutical compositions. A sustained release tablet formulation has advantages as follows: breaking out patent monopoly of the innovator preparation, drug dissolution release effects in vitro can be achieved and probably clinical treatment effects can also be accomplished consistent with that of the innovator preparation; abandoning anionic polymers used in the innovator preparation such that making the drug release and absorption not being influenced by the patent body's gastric pH values, in order to avoid the disadvantages of the innovator preparation.

Abstract: The present disclosure discloses a method, a system and a server of removing a distributed caching object. In one embodiment, the method receives a removal request, where the removal request includes an identifier of an object. The method may further apply consistent Hashing to the identifier of the object to obtain a Hash result value of the identifier, locates a corresponding cache server based on the Hash result value and renders the corresponding cache server to be a present cache server. In some embodiments, the method determines whether the present cache server is in an active status and has an active period greater than an expiration period associated with the object. Additionally, in response to determining that the present cache server is in an active status and has an active period greater than the expiration period associated with the object, the method removes the object from the present cache server.

Abstract: The present disclosure discloses a method, a system and a server of removing a distributed caching object. In one embodiment, the method receives a removal request, where the removal request includes an identifier of an object. The method may further apply consistent Hashing to the identifier of the object to obtain a Hash result value of the identifier, locates a corresponding cache server based on the Hash result value and renders the corresponding cache server to be a present cache server. In some embodiments, the method determines whether the present cache server is in an active status and has an active period greater than an expiration period associated with the object. Additionally, in response to determining that the present cache server is in an active status and has an active period greater than the expiration period associated with the object, the method removes the object from the present cache server.

Abstract: The present invention provides an apparatus and method for microdissecting a biological sample. In particular, apparatuses of the invention include a cell collecting device 100 that is operated by a pneumatic device 200. In one particular embodiment, apparatuses of the invention are used for collecting and transferring cell sample to and from cell collecting device 100.

Abstract: The present disclosure discloses a method, a system and a server of removing a distributed caching object. In one embodiment, the method receives a removal request, where the removal request includes an identifier of an object. The method may further apply consistent Hashing to the identifier of the object to obtain a Hash result value of the identifier, locates a corresponding cache server based on the Hash result value and renders the corresponding cache server to be a present cache server. In some embodiments, the method determines whether the present cache server is in an active status and has an active period greater than an expiration period associated with the object. Additionally, in response to determining that the present cache server is in an active status and has an active period greater than the expiration period associated with the object, the method removes the object from the present cache server.