Abstract: The present disclosure relates to an antibody, such as a monoclonal antibody (mAb), or an antigen-binding fragment thereof, that specifically recognizes TIGIT, and methods of making the same and using the same.

Abstract: Techniques for natural language based chat are described. In some examples, a chat service receive a request to answer a natural language query (NLQ), generate one or more embedding vectors for the NLQ, performs a search of a vector database having information regarding one or more of enterprise context, natural language summaries of enterprise context, embedding vectors for the enterprise context, and embedding vectors for natural language summaries of the enterprise context according to the request to generate a search result, augmenting the NLQ using the search result, predicts a response for the NLQ using the search result augmented NLQ, and provides the predicted response in the chat.

Abstract: Provided in the present application is an anti-Siglec 15 antibody or an antigen-binding fragment thereof, a pharmaceutical composition and immunoconjugate comprising the antibody or antigen-binding fragment, a nucleic acid molecule encoding the antibody or antigen-binding fragment thereof, a vector comprising the nucleic acid molecule, a host cell comprising the vector, a method for preparing the antibody or antigen-binding fragment, and the biological medical use of the antibody or antigen-binding fragment. The use comprises regulating the immune response, reversing the inhibition of the Siglec15 protein on PBMC lymphocyte proliferation or treating tumors associated with abnormal Siglec 15 expression.

Abstract: Provided are a method and device for preparing adiponitrile. The method of the present disclosure comprises the steps of a first hydrocyanation reaction, an isomerization reaction and a second hydrocyanation reaction, wherein online Raman spectroscopy is used for detecting the content of a specific component in the system; and the reaction conditions are regulated based on the detection results, so as to achieve precise control of the materials in each step of the reaction system. The method of the present disclosure can reduce an amount of butadiene, thereby reducing the subsequent energy consumption needed for recycling butadiene and equipment investment after reaction; by monitoring the content of hydrocyanic acid in real time, the residue of hydrocyanic acid is reduced to a lower level, and the operation safety and the stability of a catalyst during reaction are improved; and the loss of the catalyst is reduced.

Abstract: A walk-behind power tool includes: an energy source providing energy for at least the movement of a working assembly; and a blowing device including a connecting portion configured to be connected to the walk-behind power tool, a first motor driving at least fan blades to rotate to generate an airflow, and a charging portion configured to be electrically connected to the walk-behind power tool so as to cause the first motor to obtain energy.

Abstract: The present invention provides synthetic nucleic acid sequences comprising 10-30 nucleotides of the N1 and N2 gene regions and/or the 3? non-coding region of the SARS-associated coronavirus Cov-2 (SARS-CoV-2) genome, and a synthetic nucleic acid sequence comprising 10-30 nucleotides of a nucleic acid sequence that is complementary to at least one of those regions. Also provided are compositions comprising the sequences, and uses of the sequences in diagnostic kits. The present invention further provides a primer and probe set for determining the presence or absence of SARS-associated coronavirus Cov-2 in a biological sample, wherein the primer set comprises at least one of the synthetic nucleic acid sequences. Also provided are a composition comprising the primer and probe set, and use of the primer and probe set in a diagnostic kit. Finally, the present invention provides kits and methods for determining the presence or absence of SARS-associated coronavirus Cov-2 (SARS-CoV-2) in a biological sample.

Abstract: Provided here are neural network-based methods and systems that process nucleic acid sequences to identify, characterize, and interpret specific properties, like characterization of promoters of gene sequences, identification of viral genomes, and stability of the nucleic acids. The neural network models can be trained in supervised, unsupervised, and semi-supervised environments.

Abstract: The invention provides a method for detecting KRAS mutations at one or more of codons, said method comprising the steps of: (a) extracting DNA from a biological sample; (b) assaying the DNA via PCR for KRAS mutations at one or more of codons with at least one set of oligonucleotides, wherein the at least one set of oligonucleotides comprises an allele specific forward primer, a reverse primer, a probe and a xenonucleic acid clamp to block amplification of wild type DNA. The xenonucleic acid clamps have aza-aza, thio-aza and oxy-aza chemical functionality.

Abstract: One variation of a method includes: accessing a 2D color image recorded by a 2D color camera and a 3D point cloud recorded by a 3D depth sensor at approximately a first time, the 2D color camera and the 3D depth sensor defining intersecting fields of view and facing outwardly from an autonomous vehicle; detecting a cluster of points in the 3D point cloud representing a continuous surface approximating a plane; isolating a cluster of color pixels in the 2D color image depicting the continuous surface; projecting the cluster of color pixels onto the plane to define a set of synthetic 3D color points in the 3D point cloud, the cluster of points and the set of synthetic 3D color points representing the continuous surface; and rendering points in the 3D point cloud and the set of synthetic 3D color points on a display.

Abstract: A cleaning device, a storage apparatus for the cleaning device, and a cleaning system are provided. The cleaning device includes a body and a connecting portion, the body or the connecting portion is provided with an attraction member, and the attraction member is configured to attract a surface to be attracted.

Abstract: A cleaning tool, including a suction pipe, a brush head outer casing, a motor casing, and a brush head. The cleaning tool further includes: a brush head inner casing, which is relatively rotatably provided in the brush head outer casing and forms an accommodation cavity of the brush head; and a bottom plate, which is integrally formed with the brush head inner casing and forms a cleaning contact surface of the cleaning tool. The bottom plate includes a front raised portion and a rear raised portion.

Abstract: A cleaning apparatus, including: a suction system; a separation system; a filtration system; and a garbage collection system at least comprising a first garbage collection cavity configured to collect garbage passing through a primary separation system and a second garbage collection cavity configured to collect garbage passing through a secondary separation system, wherein the first garbage collection cavity and the second garbage collection cavity have a common airtight cover, a bottom of the second garbage collection cavity and a bottom of the first garbage collection cavity are located on the airtight cover in a direction extending outward from a center of the airtight cover, and the first garbage collection cavity and the second garbage collection cavity are isolated in a sealed manner in a direction perpendicular to a surface of the airtight cover.

Abstract: Provided are a method and device for preparing adiponitrile. The method of the present disclosure comprises the steps of a first hydrocyanation reaction, an isomerization reaction and a second hydrocyanation reaction, wherein online Raman spectroscopy is used for detecting the content of a specific component in the system; and the reaction conditions are regulated based on the detection results, so as to achieve precise control of the materials in each step of the reaction system. The method of the present disclosure can reduce an amount of butadiene, thereby reducing the subsequent energy consumption needed for recycling butadiene and equipment investment after reaction; by monitoring the content of hydrocyanic acid in real time, the residue of hydrocyanic acid is reduced to a lower level, and the operation safety and the stability of a catalyst during reaction are improved; and the loss of the catalyst is reduced.

Abstract: A rapid construction method for a secondary lining of a small-section tunnel includes steps of: transporting and store secondary lining steel bars to a designated position in the tunnel with a steel bar transport vehicle and a wheel type dump truck; after the tunnel is cleaned, simultaneously constructing the secondary lining from two ends to a middle of the tunnel; constructing a lower inverted arch with a customized inverted arch formwork and then constructing an upper arch wall with a plurality of portal arch wall formwork trolleys; wherein the portal arch wall formwork trolleys form a set, and are connected by hinges, so as to construct in a curve tunnel. The rapid construction method has a long single construction section, and procedure connection is compact, thereby realizing rapid and efficient construction of the secondary lining.

Abstract: One variation of a method includes: accessing a 2D color image recorded by a 2D color camera and a 3D point cloud recorded by a 3D depth sensor at approximately a first time, the 2D color camera and the 3D depth sensor defining intersecting fields of view and facing outwardly from an autonomous vehicle; detecting a cluster of points in the 3D point cloud representing a continuous surface approximating a plane; isolating a cluster of color pixels in the 2D color image depicting the continuous surface; projecting the cluster of color pixels onto the plane to define a set of synthetic 3D color points in the 3D point cloud, the cluster of points and the set of synthetic 3D color points representing the continuous surface; and rendering points in the 3D point cloud and the set of synthetic 3D color points on a display.

Abstract: A multilayer laminate film assembly is provided, which includes at least two multilayer substrate films, each substrate film having at least a first outer layer and a second outer layer, and wherein the at least two multilayer substrate films each include at least two layers of a different class of material. In the laminate film assembly, the at least two substrate films are laminated together, preferably wherein the class of material of the first outer layer differs from the class of material of the second outer layer. The multilayer substrate films are from the same type of substrate. A standing pouch is further provided which includes a front panel, a back panel, and a bottom panel, wherein all panels are from the multilayer laminate film.

Abstract: The invention provides a multiplex method for enriching a plurality of target polynucleotide sequences containing genetic mutations associated with lung cancer comprising: (a) providing a biological sample; (b) isolating DNA from said sample; said DNA including said plurality of target polynucleotide sequences containing genetic mutations; (c) providing a plurality of primer probes targeted to said target polynucleotide sequences said primer probes allowing formation of a PCR product; (d) providing a plurality of target specific xenonucleic acid clamps oligomer probes specific for wildtype polynucleotide sequences; so that during the qPCR process only mutant templates are amplified: (e) admixing the plurality of primer probes and the plurality of xenonucleic clamping probes with the target nucleic acid sample; (f) performing a PCR amplification process in reaction solution under hybridization conditions thereby generating multiple amplicons; and (g) detecting said amplicons and wherein said xenonucleic acid c

Abstract: The invention provides a method for detecting KRAS mutations at one or more of codons, said method comprising the steps of: (a) extracting DNA from a biological sample; (b) assaying the DNA via PCR for KRAS mutations at one or more of codons with at least one set of oligonucleotides, wherein the at least one set of oligonucleotides comprises an allele specific forward primer, a reverse primer, a probe and a xenonucleic acid clamp to block amplification of wild type DNA. The xenonucleic acid clamps have aza-aza, thio-aza and oxy-aza chemical functionality.