Abstract: Novel compounds, compositions, and methods of using and preparing the same, which maybe useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Provided herein are compositions comprising borate-acid buffers, as well as methods of using these compositions in oil and gas operations, including enhanced oil recovery (EOR) operations, fracturing operations, stimulation operations, etc.

Abstract: Embodiments of the disclosure include compositions and methods that stabilize a injection fluid when exposed to reservoir conditions, reducing formation damage and increasing the amount of hydrocarbon recovered. Specifically, the formulation is a single-phase liquid surfactant package which comprises a non-ionic surfactant and optionally one or more secondary surfactants.

Abstract: Described herein are compositions and methods that stabilize an injection fluid when exposed to reservoir conditions, reducing formation damage and increasing the amount of hydrocarbon recovered. Specifically, the formulation is a single-phase liquid surfactant package which comprises an anionic surfactant including a hydrophobic tail comprising from 6 to 60 carbon atoms and optionally one or more secondary surfactants.

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: The present disclosure relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics. Also provided are methods of measuring C5 and related complexes using C5 binding agents.

Abstract: The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: Indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Abstract: Pyrano[4,3-b]indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD)

Abstract: 1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Abstract: 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: The present disclosure presents compounds and compositions that interact with complement components. Some compounds inhibit complement activity. Included are small molecule compounds and compositions that function as C5 inhibitor compounds. Methods for inhibiting complement activity and methods of treating complement-related indications with the C5 inhibitor compounds and compositions are provided.

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Described herein are surfactant compositions for use in oil and gas operations. The surfactant compositions are stable under harsh conditions, including in formations that exhibit high salinity, high temperature, and/or high H2S concentration. Also provided are methods of using these compositions. Specifically an aqueous composition comprising: (i) a surfactant package, wherein the surfactant package comprises: (a) a surfactant comprising a branched, unbranched, saturated, or unsaturated C6-C32:80(0-65):PO(0-65):EO(0-100)-X having a concentration within the aqueous composition of from 0.05%-5% by weight, based on the total weight of the aqueous composition, wherein there is at least one BO, PO, or EO group, and wherein X comprises a sulfonate, a disulfonate, a carboxylate, a dicarboxylate, a sulfosuccinate, a disulfosuccinate, or hydrogen: and (b) olefin sulfonate and/or a disulfonate; and (ii) water.

Abstract: A sample collecting device is provided. The sample collecting device includes a frame, a collect part and a control part. The collect part is disposed in the frame and is provided with a collecting cavity having a collecting port, and the collect part is used to make a sample flow into the collecting cavity from the collecting port. The control part is disposed in the frame, used to make a collecting rod put into a reagent bottle be pulled out and inserted into the collecting cavity to thereby collect the sample, and used to make the collecting rod with the sample be pulled out from the collecting cavity and put back into the reagent bottle. The collecting of sample without manual intervention is realized, effectiveness and consistency of the collected samples are ensured, and the labor cost is reduced.

Abstract: A fully-automatic transplanting combined machine includes a traction apparatus, operation apparatus and a control system. The operation apparatus is mounted on the traction apparatus with a main body frame and is towed behind the traction apparatus. The operation apparatus includes a rotary tillage furrowing system, a system for slightly preparing soil and opening narrow furrows, a planting system, and a soil covering compacting system which are arranged successively from front to back. The planting system includes more than one planting unit. The fully-automatic transplanting combined machine is capable of orderly performing rotary tillage, cleaning stubble, leveling a border check, opening a furrow, cutting narrow slits, transplanting, covering soil, compacting soil in untilled soil at one process, so as to create the soil requirements for high-speed transplanting of blanket seedlings such as rape and other crops.

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.