Abstract: Provided is a site-specific PEG-modified interleukin 2 (IL-2) mutant. Compared with a parent IL-2, the mutant has an improved preference for a Treg cell and a prolonged half-life period. Also provided are a composition comprising the IL-2 mutant, a nucleic acid encoding the IL-2 mutant, a vector comprising the nucleic acid, and a host cell. Further provided are the IL-2 mutant and therapeutic use of a pharmaceutical composition comprising same.

Abstract: The present disclosure discloses a concrete block apparatus for ash slag after coal gasification. The present disclosure relates to the field of ash slag concrete processing technology after coal gasification. including an apparatus; the first connecting frame is installed on the outside of the apparatus; the chute is opened in the interior of the apparatus; the first chute board is connected to the inside of the chute; the moving mechanism is connected to the first connecting frame, the moving mechanism includes the second chute board and the third chute board, the external of the second chute board and the third chute board is provided with a moving frame, the second chute board and the third chute board are used to control the moving frame in and out of the apparatus, the placing mechanism is connected to the moving mechanism.

Abstract: Configuration settings are dynamically distributed from a server to one or more data centers serving cloud-native applications. The server sends a first set of configuration settings to a data center in response to an initialization of an application at the data center. Subsequently, the server sends second sets of configuration settings to the data center, each second set including only new, modified, or deleted configuration settings. The second sets are sent either at predetermined intervals or in response to a request message from a data center. Configuration settings may be compressed prior to sending and/or storing.

Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

Abstract: A coal gasification slag all-solid waste cementitious material and a preparation method thereof belong to the field of comprehensive utilization of resources and mining technology, the coal gasification slag all-solid waste cementitious material and the preparation method thereof adopt coal gasification slag, granulated blast furnace slag, desulfurization ash, desulfurization gypsum, carbide slag, and other mine or industrial solid waste with low cost. After resource utilization, the problem of solid waste accumulation is effectively solved, and the pressure on the ecological environment is reduced. A process of calcination and activation of coal gasification slag without auxiliary fuel is proposed, the calcination temperature is 400-500 °C. The high content residual carbon in coal gasification slag is used to provide the heat value of calcination, reduce the external energy consumption, and enhance the combustion rate.

Abstract: The present disclosure belongs to the field of solid waste resource utilization and building materials technology, specifically relates to a copper molybdenum tailings based alkali activated cementitious material and preparation method. The copper molybdenum tailings based alkali activated cementitious material including: solid waste dry mixture, alkali activator solution, silicone acrylic lotion and modified nano-silica; where the solid waste dry mixture is composed of 50-70 parts of copper molybdenum tailings; 10-30 parts of auxiliary calcium material; 10-20 parts of silicon aluminum correction material. The method of the present disclosure can achieve a large-scale consumption of copper molybdenum tailings and prepare cementitious materials with excellent mechanical properties and good stability.

Abstract: Embodiments of this specification provide acquiring apparatuses, methods, and computer program product. An acquiring apparatus includes a controller, a first near field communication (NFC) module, and a second NFC module. The first NFC module and the second NFC module work under control of the controller. The first NFC module is configured to work in a card reader mode, and in the card reader mode, the first NFC module is configured to transmit a first radio frequency signal, detect first response information, and obtain customer information based on the first response information. The second NFC module is configured to work in a card emulation mode, and in the card emulation mode, the second NFC module is configured to send second response information comprising merchant acquiring information in response to sensing a second radio frequency signal.

Abstract: A blocking mechanism includes a blocking assembly and a trigger member. The blocking assembly includes a transmission member, a blocking member, and an elastic member. The blocking member includes a first position for blocking and a second position for unblocking. The transmission member is connected to the blocking member, and the elastic member can place the blocking member in the first position; and the trigger member can contact the transmission member along two opposite directions of the transmission member to place the blocking member in the second position.

Abstract: Systems and methods for generating low-high quality data pairs for training a denoising model are provided. A communication platform accesses a first set of video data with a first noise level above a first threshold value. The communication platform extracts a noise sequence from the first set of video data. The communication platform augments one or more noise frames of the noise sequence in one or more aspects to obtain one or more augmented noise frames. The communication platform applies the one or more augmented noise frames to a second set of video data with a second noise level below a second threshold value to generate a third set of video data. The communication platform generates a pair of training video data comprising the second set of video data and the third set of video data to train a machine learning model for denoising video data.

Abstract: This disclosure belongs to the technical field of biomedicine, and discloses use of a mimetic peptide containing a fibrinogen RGD motif in preparation of medications for preventing and/or treating Parkinson's disease. A sequence of the mimetic peptide containing the fibrinogen RGD motif of this disclosure is: Gly-Arg-Gly-Asp-Ser-Pro-Leu-Ala-Pro-Ser-Cys. The applicant of this disclosure has found through research that there is abnormal accumulation of FG in substantia nigra pars compacta of PD mice, and that excessively accumulated FG in the brain may promote abnormal aggregation of ?-syn in dopaminergic neurons under mediation of ?v?3 integrin receptor. The mimetic peptide provided by this disclosure can effectively inhibit the abnormal aggregation of ?-syn in the dopaminergic neurons and death of the dopaminergic neurons caused by the abnormally accumulated FG in the brain, improve a motion ability of MPTP-modeled PD mice, and provide a new target and idea for PD treatment.

Abstract: The present disclosure provides a ventilation structure for a crankcase, and belongs to the technical field of engines. In the ventilation structure for a crankcase, the crankcase includes a crankshaft chamber and a ventilation chamber, the ventilation structure includes a one-way valve plate enabling only gas in the crankshaft chamber to flow into the ventilation chamber, an inner side wall of the ventilation chamber is provided with a backflow groove, an inner cavity of the backflow groove communicates with the crankshaft chamber, the one-way valve plate is disposed in an up-down direction and can close an opening of the backflow groove, an upper end of the one-way valve plate is a free end, and a lower end of the one-way valve plate is fixedly connected to an open end face of the backflow groove.

Abstract: A helium genesis resource evaluation method comprises: determining the content of a decayed daughter isotope in a helium source rock at a target area; determining the amount of substance of helium in the helium source rock on the basis of the content of the decayed daughter isotope in the helium source rock; determining a total helium production amount of the helium source rock on the basis of the amount of substance of the helium in the helium source rock; determining a migration-accumulation coefficient of the helium in the helium source rock at the target area; and determining a helium accumulation resource amount on the basis of the migration-accumulation coefficient and the total helium production amount of the helium source rock. The method can realize effective evaluation on helium resources, and has an important guidance effect on conducting a research on helium reservoir formation and enrichment rule.

Abstract: The present invention provides methods and systems for antibody-independent spatial proteomics analysis using wavelength-specific click chemistry. Photoactivatable click chemistry reagents responsive to distinct wavelengths (UV, blue, green, red) are introduced into biological samples and selectively activated using laser matrix systems with submicron spatial control. Wavelength-specific activation enables simultaneous labeling of proteins at multiple subcellular locations or tissue regions, followed by mass spectrometry analysis to determine spatial protein distributions with subcellular resolution. The technology eliminates antibody dependencies while providing comprehensive proteome coverage (1000+ proteins per spatial region) at significantly reduced cost and time compared to conventional methods. Applications include clinical cancer diagnostics, drug discovery screening, and research applications across diverse biological systems including cell cultures, tissue sections, and FFPE clinical specimens.

Abstract: The present disclosure pertains to a method for optimizing open-pit mine limits with simultaneous consideration of mining carbon emissions and slope safety, comprising the following steps: establishing a three-dimensional model of the mine; establishing a carbon emission calculation model for open-pit mining; determining rock indices and rock types of the mine; dividing the mining area into geological zones, determining an acceptable slope angle range for each zone, and forming slope angle combination schemes; calculating the final limit under each slope angle combination one by one; obtaining a sequence of three-dimensional geological models of the limits; calculating the slope instability probability for each zone; calculating the carbon emissions for each limit; dividing the limit results according to the acceptable slope instability probability indices, and directly calculating the benefit evaluation indices for results that meet the requirement; designing reinforcement schemes for results that do not mee

Abstract: A computing device receives streaming data from one or more security sensors at a geographic location, the one or more security sensors comprising at least one of a camera, a microphone, or a thermal sensor. The computing device determines, by an artificial intelligence engine, an event occurring at the geographic location based on the streaming data based on receiving the streaming data, the artificial intelligence engine including at least one convolutional neural network and at least one transformer. The computing device transmits, to an output device, an alert corresponding to the event.

Abstract: This application discloses a code block transmission method and apparatus, a device, a system, and a chip, and relates to the field of communication technologies. The method is applied to a first control unit connected to a first Ethernet interface, and the method includes: obtaining statuses of N lanes between the first Ethernet interface and a second Ethernet interface; stopping, based on the statuses indicating that M lanes in the N lanes are faulty, transmitting a first code block obtained based on service data to the second Ethernet interface through the M lanes; and transmitting the first code block to the second Ethernet interface through N-M lanes in the N lanes, and transmitting a second code block different from the first code block to the second Ethernet interface through the M lanes, where M is a positive integer less than N.

Abstract: The battery apparatus includes: a box body; at least two mounting members connected to the box body; and a first sealing assembly disposed on at least one of the mounting members and having a connection end and a protrusion end, where the connection end is connected to a connection surface of the corresponding mounting member, the protrusion end protrudes from the connection surface of the corresponding mounting member, and the protrusion end is sealed between the at least two mounting members. The first sealing assembly is integrated onto the at least one mounting member, so that the first sealing assembly and the corresponding mounting member are formed into an integral structure, which can simplify a mounting and sealing structure. The protrusion end of the first sealing assembly can be better clamped between two structures that require sealing, for example, clamped between two mounting members.

Abstract: Techniques for database double write monitoring are disclosed. In an example method, a computing system receives indications of first and second database writes to respective first and second databases. The computing system determines a time interval between the first and second database writes. The computing system, responsive to the time interval being less than a predefined threshold time interval, determines a difference between the first and database writes based on a comparison of the two database writes. The computing system, responsive to the difference indicating that a double write error has occurred, generates a double write error object including information about the first and second database writes. The computing system outputs an instruction to an issue tracking system, based on the double write error object, to cause automatic correction of the double write error.

Abstract: A light-emitting device includes a light-emitting element including an epitaxial structure and a DBR. The DBR includes first and second reflective units. The first reflective unit includes first reflective structures. The second reflective unit includes second reflective structures. Each of the first and second reflective structures has first and second material layers. The first material layer of each of the first reflective structures has an optical thickness different from that of the first material layer of each of the second reflective structures. The second material layer of each of the first reflective structures has an optical thickness different from that of the second material layer of each of the second reflective structures. In each of the first and second reflective structures, the first material layer has a refractive index different from that of the second material layer.

Abstract: A method, computer system and computer program product for model compression service. The method comprises determining an initial deep neural network (DNN) and an associated compression algorithm available in a compression engine, a type of target hardware and a performance requirement of target hardware. The method also comprises emulating a plurality of different compressed models of the initial DNN on target hardware of the type to obtain corresponding runtime performance data, wherein the different compressed models are defined with different configuration data. The method further comprises obtaining a runtime performance estimator of the target hardware by regression with the different configuration data and the corresponding runtime performance data. Lastly, the method comprises applying the runtime performance estimator to the compression algorithm by the compression engine to generate a compressed DNN of the initial DNN complying with the performance requirement of the type of target hardware.