Abstract: In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for enhanced ophthalmic visualization. A plurality of images corresponding to different portions of the electromagnetic spectrum are obtained and combined, such as by pixel-wise subtraction to obtain a combined image. The images may be weighted with weights selected to enhance visualization of features, such as layers of the retina or features corresponding to pathologies. The combined image may be processed, such as by a machine learning model, to extract features.

Abstract: In certain embodiments, a system, a computer-implemented method, and computer-readable medium are disclosed for performing integrated analysis of MSI and OCT images to diagnose eye disorders. MSI and OCT are processed using separate input machine learning models to create input feature maps that are input to an intermediate machine learning model. The intermediate machine learning model processes the input feature maps and outputs a final feature map that is processed by one or more output machine learning models that output one or more estimated representations of a pathology of the eye of the patient. A single device captures OCT and non-OCT images using (a) a sensor of a first imaging device that is shared with a second imaging device and/or (b) an optical component for directing light form the retina to the first imaging device or the second imaging device.

Abstract: A respiratory droplet suction device includes an air inlet end and an exhaust end. A plurality of filtering devices are arranged between the air inlet end and the exhaust end. The filtering device is provided with a bacteria filtering screen for adsorbing bacteria and an ultraviolet sterilization lamp for inactivating the bacteria. The filtering device includes a first side wall and a second side wall. The first side wall is connected to the air inlet end, and the second side wall is connected to the exhaust end. The air entering from the first side wall is filtered by the bacteria filtering screen and discharged through the second side wall. The ultraviolet sterilization lamp is arranged corresponding to the bacteria filtering screen. A respiratory droplet filtering apparatus includes the respiratory droplet suction device, and a respiratory droplet electric suction system includes the respiratory droplet filtering apparatus are further provided.

Abstract: The present invention relates to a tetracyclic derivative, a method for preparing same and the use thereof in medicine. In particular, the present invention relates to a tetracyclic derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, especially as a K-Ras GTPase inhibitor, with definitions of each substituent in general formula (I) being the same as of which are defined in the description.

Abstract: In certain embodiments, a system for obtaining ophthalmic information includes an illumination device having an optical fiber; a hyperspectral illumination source; a controller; a modulation device; and an imaging device. The modulation device is configured to receive first source light generated from the hyperspectral illumination source. The first source light includes multiple wavelengths. The modulation device is also configured to modulate each of the wavelengths with a different frequency to generate second source light having multiple frequency modulated wavelengths, and transmit the second source light to an optical fiber, which emits the second source light to contact an eye tissue. The imaging device selects a first frequency associated with a first frequency modulated wavelength and captures light returning from the eye tissue as a result of the first frequency modulated wavelength contacting the eye tissue. The controller determines parameter(s) of the eye tissue based on the return light.

Abstract: In certain embodiments, an optical system for obtaining surgical information includes a probe housing a first optical fiber, a light source, a photoanalyzer, and an optical circulator optically coupled to each of the first optical fiber, the light source, and the photoanalyzer. The optical circulator has a first port configured to receive source light generated from the light source, a second port configured to transmit the source light from the first port to the first optical fiber, and a third port configured to transmit return light in the first optical fiber from the second port to the photoanalyzer. The first optical fiber is configured to emit at least a portion of the source light in the first optical fiber from the probe to contact a body structure, and collect light returning from the body structure as a result of the portion of the source light contacting the body structure.

Abstract: An instrument to facilitate hands-free illumination of an eye for a surgical procedure. The instrument includes an optical end of unique architecture and surfacing such that the instrument may be left immobile while sufficiently illuminating an eye interior with greater than 100° of wide beam spread angle provided. Further, the grind surfacing provided to the end cone of the optical end provides enhanced light distribution.

Abstract: Provided are a macrolide derivative represented by formula (I), a preparation method thereof, and an application of the macrolide derivative as an inhibitor of one or more protein kinases of TRK, ALK and ROS1,

Abstract: A handheld diagnostic test device includes a port to removably receive a test cartridge, an element connected with an electronic device, and sensors for detection of test data from a biological or environment sample after reaction with reagents onboard the cartridge. The test device also includes memory storing algorithms for upload to the electronic device to enable a processor thereof: to await elapse of a pre-determined time following reaction of the sample with the reagents; to thereafter instruct the sensors to detect the test data; to generate presentation data based on the test data; and to present the presentation data from a presentation element of the electronic device to a user. A related method includes a connecting step, an uploading step, a presentation step, a cartridge inserting step, a waiting step, a sensing step, and an electronic device processing step.

Abstract: A pump and valve combination for bladder adjustment is revealed and including a fluid supply member, a valve member and a bypass line. The fluid supply member includes a head end and a tail end. A bottom cover is disposed on the tail end and the fluid supply member provides fluid to the bottom cover through the tail end. The valve member is arranged at the head end and communicating with bladders. The valve member includes a valve cap fixed on the head end, a solenoid operated directional control valve, and an air supply tube. Two ends of the bypass line are connected to the bottom cover and an air input end of the air supply tube, respectively. An input portion and an output portion of the solenoid operated directional control valve are connected to an air output end of the air supply tube and the bladder respectively.

Abstract: Embodiments disclosed herein provide devices, systems, and methods for illuminating inside an eye globe. More particularly, the present disclosure relates to ergonomic chandelier illumination systems for illumination of a surgical site during ophthalmic surgery, the chandelier illumination systems having improved flexibility, profile, and light coupling efficiency. In certain embodiments, a malleable chandelier illumination probe, which is bendable by a surgeon to any desired angle, is disclosed. In certain other embodiments, a preformed chandelier illumination probe, which is preset to a desired angle using a heating method, is disclosed. In certain other embodiments, a method for belling and binding two optical fibers to create a dual chandelier output with improved light coupling efficiency, which is capable of being used with a single connector, is disclosed.

Abstract: A pneumatic pump having an overpressure protection valve having a gasket and spring that includes a diaphragm carrier, a diaphragm member, a valve base, a valve, a cap, a driving device and an overpressure protection valve is revealed. A pump chamber is formed between the diaphragm member and the valve base. The overpressure protection valve having a spring and a gasket. A discharge channel, an air-flow channel and a backflow channel are formed among the pump chamber, the valve base, the valve and the cap. The discharge channel, the overpressure protection valve and the spring chamber are separated. The gasket is disposed between the air-flow channel and the backflow channel for closing the air-flow channel normally. The driving device drives the diaphragm member for discharging air from the pump chamber through the discharge channel.

Abstract: A respiratory droplet suction device includes an air inlet end and an exhaust end. A plurality of filtering devices are arranged between the air inlet end and the exhaust end. The filtering device is provided with a bacteria filtering screen for adsorbing bacteria and an ultraviolet sterilization lamp for inactivating the bacteria. The filtering device includes a first side wall and a second side wall. The first side wall is connected to the air inlet end, and the second side wall is connected to the exhaust end. The air entering from the first side wall is filtered by the bacteria filtering screen and discharged through the second side wall. The ultraviolet sterilization lamp is arranged corresponding to the bacteria filtering screen. A respiratory droplet filtering apparatus includes the respiratory droplet suction device, and a respiratory droplet electric suction system includes the respiratory droplet filtering apparatus are further provided.

Abstract: A mini air pump which includes a diaphragm, a bladder base provided with penetrating bladder holes and air inlet channels, a pump body having a valve seat and a pump cover, an air inlet valve, an air outlet valve, a relief valve and a preload member is revealed. The valve seat is stacked over the diaphragm. An exhaust chamber and a spring chamber are constructed by the valve seat and the pump cover. The valve seat has exhaust channels communicating with the bladder cavity. A communicating return channel is constructed by the diaphragm, the bladder base and the valve seat. The return channel is communicating with the air inlet channel but not communicating with the spring chamber. A spring of the preload member applies a preload to the relief valve. Thereby the relief valve acts more accurately and the mini air pump is more stable in use.

Abstract: A motor includes a stator, a rotor rotatable relative to the stator, a support member, and a circuit assembly. The circuit assembly includes a plurality of electronic components. The rotor is rotatably mounted to the support member. The stator is received in the rotor. The stator is fixed to the support member, and the support member is at least partially received in an inner side of the stator. A portion of the support member received in the inner side of the stator defines a receiving space, and at least part of the electronic components of the circuit assembly is received in the receiving space of the support member. The support member is partially received in the inner side of the stator, and the circuit assembly is at least partially received in the support member, which makes the motor have a relatively smaller axial size.

Abstract: A respirator mask. The respirator mask has a filter that extends around at least a portion of the perimeter of the mask itself, leaving a central area that coincides with the position of the wearer's mouth unobstructed. A front panel of the mask may be transparent over at least the central area in order to allow the mouth to be seen while the mask is worn. The filter may be a pleated particulate filter, a chemical/gas filter, or a filter of mixed type. The front panel may also include other features, like a port for a drinking straw. The respirator mask may include headgear.

Abstract: An ECU, a control box, and a CMF using the ECU are provided. The control box includes a heat sink and the ECU. The ECU include a support bracket mounted on the heat sink, a power supply board supported by the support bracket, and a signal board stacked over the power supply board and electrically connecting with the power supply board. The support bracket is made of an insulation material. The power supply board carries a plurality of power devices which are in contact with the heat sink for heat dissipation multiple power devices.

Abstract: A pump and valve combination for bladder adjustment is revealed and including a fluid supply member, a valve member and a bypass line. The fluid supply member includes a head end and a tail end. A bottom cover is disposed on the tail end and the fluid supply member provides fluid to the bottom cover through the tail end. The valve member is arranged at the head end and communicating with bladders. The valve member includes a valve cap fixed on the head end, a solenoid operated directional control valve, and an air supply tube. Two ends of the bypass line are connected to the bottom cover and an air input end of the air supply tube, respectively. An input portion and an output portion of the solenoid operated directional control valve are connected to an air output end of the air supply tube and the bladder respectively.