Abstract: The present invention concerns production of a compound of the formula or a pharmaceutically acceptable salt thereof by a process which utilizes the cyclization of a compound of the formula: where Ar, Y, R1, Ry, R2, and m are as defined herein.

Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.

Abstract: Disclosed is a method for converting an input digital color image having a set of possible input colors to an output digital color image having a set of palette colors, the number of palette colors being less than the number of possible input colors, wherein the set of palette colors is determined based on the distribution of colors in the input digital image boosted by a distribution of important colors contained in the input digital image.

Abstract: A method of storing an image in a digital camera, comprising the steps of: capturing the image using the selected quantization table. A method of storing an image in a digital camera, wherein the step of selecting a quantization table comprises the steps of: selecting a quality setting; compressing the image using a quantization table corresponding to the selected quality setting; decompressing the image; evaluating the decompressed image with the image quality metric; and, adjusting the quantization table such that the quality metric matches the selected quality setting.

Abstract: Disclosed is a method for converting an input digital color image having a set of possible input colors to an output digital color image having a set of palette colors, the number of palette colors being less than the number of possible input colors, wherein the set of palette colors is determined based on the distribution of colors in the input digital image supplemented by a distribution of important colors.

Abstract: The invention provides a method for detecting the presence of altered serum proteins in an Hepatitis B Virus (HBV)-infected patient with liver inflammation, comprising: obtaining a sample of serum from the patient; subjecting the sample to protein gel electrophoresis to separate proteins contained therein; staining proteins separated on the electrophoresis gel with silver nitrate solution; scanning the images of stained proteins into an image analysis scanner to obtain gel images; comparing the gel images to control samples of electrophoresis gels prepared from serum of normal patient and serum of HBV-infected patient with liver inflammation to determine whether the sample of serum from the patient contains specific serum proteins. This invention also provides serum protein biomarkers for the diagnosis of patients with HBV infection and liver inflammation.

Abstract: The present invention relates to a process conducted in a single reaction vessel for producing a dioxolane nucleoside analogue of formula I or a pharmaceutically acceptable salt thereof; the process comprising the steps of adding a Lewis acid, a silylating agent and a non-silylated purine or pyrimidine base or an analogue thereof to a dioxolane of formula II. The invention also provides a process for producing a dioxolane compound of formula III; by reacting a dioxolane compound of formula IV in a suitable solvent in the presence of DIB and I2, using a suitable source of energy.

Abstract: Disclosed is a method for converting an input digital color image having a set of possible input colors to an output digital color image having a set of palette colors, the number of palette colors being less than the number of possible input colors, wherein the set of palette colors is determined based on the distribution of colors in the input digital image boosted by a distribution of important colors contained in the input digital image.

Abstract: Disclosed is a method for converting an input digital color image having a set of possible input colors to an output digital color image having a set of palette colors, the number of palette colors being less than the number of possible input colors, wherein the set of palette colors is determined based on the distribution of colors in the input digital image boosted by a distribution of important colors contained in the input digital image.

Abstract: A digital image processing determining the extent of blocking and contouring artifacts in a digital image includes the steps of: determining the extent of blocking artifacts using the column and row difference arrays; determining the extent of contouring artifacts based on an estimated DC quantization step size; and, determining a composite artifact measure as a function of the extent of blocking artifacts and extent of contouring artifacts.

Abstract: The invention provides a method for detecting the presence of altered serum proteins in an Hepatitis B Virus (HBV)-infected patient with liver inflammation, comprising: obtaining a sample of serum from the patient; subjecting the sample to protein gel electrophoresis to separate proteins contained therein; staining proteins separated on the electrophoresis gel with silver nitrate solution; scanning the images of stained proteins into an image analysis scanner to obtain gel images; comparing the gel images to control samples of electrophoresis gels prepared from serum of normal patient and serum of HBV-infected patient with liver inflammation to determine whether the sample of serum from the patient contains specific serum proteins. This invention also provides serum protein biomarkers for the diagnosis of patients with HBV infection and liver inflammation.

Abstract: A digital image processing method for adaptively sub-sampling an image to X % of original pixels, includes the steps of generating an edge map of the image; normalizing the edge map to N-bits; applying a shift to the normalized edge map such that X % of the pixels will be ones when the normalized shifted edge map is halftoned using a blue noise halftoning technique; halftoning the edge map using the blue noise halftoning technique to generate a halftone mask; and sub-sampling the image at the pixel locations represented by ones in the halftone mask.

Abstract: A digital image processing method for generating a low resolution, low bit depth digital image from a higher resolution, higher bit depth input color digital image, includes the steps of: generating a gray scale image from the input color digital image; generating a low resolution sketch image from the grayscale image; generating a low resolution halftone image from the gray scale image; and combining the low resolution sketch image and the low resolution halftone image to form the low resolution, low bit depth digital image.

Abstract: A method of producing a halftoned digital image having an embedded message includes using a digital message and at least one digital carrier image to produce a scrambled message image, and halftoning the digital image employing an error diffusion process where noise is added to the digital image, the noise including the scrambled message image.

Abstract: A digital image processing method determines the extent of blocking artifacts in a digital image by first forming a column difference image and averaging the values in the columns in the column difference image to produce a column difference array. The average of the values in the column difference array that are separated by one block width are computed to produce a block averaged column difference array. Then, the peak value in the block averaged column difference array is located, and the mean value of the block averaged column difference array (excluding the peak value) is calculated to produce a column base value, and the ratio between the peak value and the base value are computed to produce a column ratio. The foregoing steps are repeated in the row direction to produce a row ratio. Finally, the column and row ratios are employed as a measure of the extent of blocking artifacts in the digital image.

Abstract: A digital image processing method reduces noise and blocking artifacts in a digital image by first converting the RGB values of the digital image pixels to Y, Cb and Cr components, then detecting the block boundaries in the Y, Cb and Cr image components, and estimating the noise in the Y, Cb and Cr image components. One or more noise tables are constructed for the Y, Cb and Cr image components. An adaptive Huber-Markov-random-field-model-based filter (HMRF) is applied to the Y, Cb and Cr image components, wherein the adaptive feature of the HMRF employs the detected block boundaries and the noise tables to produce filtered Y, Cb and Cr image components. Finally, the filtered Y, Cb and Cr image components are converted to RGB components.

Abstract: A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): 1

Abstract: A digital image processing method for generating a low resolution, low bit depth digital image from a higher resolution, higher bit depth input color digital image, includes the steps of: generating a gray scale image from the input color digital image; generating a valley image; filtering the valley image with a rank order filter to produce a filtered valley image; thresholding the filtered valley image to generate a binary valley image; generating a shadow image and a highlight image from the gray scale image; combining the shadow image, the highlight image, and the binary valley image to produce a combined binary image; and sub-sampling the combined binary image to a desired low resolution.

Abstract: A method for halftoning a multi-channel digital color image having an x,y array of color pixel values, wherein at least two color channels are similar having substantially the same color but with low- and high-densities, includes the steps of: providing a matrix of dither values for each group of similar color channels wherein two or more of the matrices of dither values are designed jointly to minimize a visual cos t function; for at least one group of similar color channels, forming an inverted matrix of dither values by subtracting the value of each element of the matrix of dither values for that group from a predetermined maximum value, associating the inverted matrix of dither values with one of the low- or high-density color channels, and associating the matrix of dither values for that group with the other low- or high-density color channel of that group; for each color channel of the multi-channel digital color image modularly addressing the matrix of dither values associated with that color channel u

Abstract: Disclosed is a method for converting an input digital color image having a set of possible input colors to an output digital color image having a set of palette colors, the number of palette colors being less than the number of possible input colors, wherein the set of palette colors is determined based on the distribution of colors in the input digital image boosted by a distribution of important colors contained in the input digital image.