Abstract: The present application provides single-domain antibodies targeting CD33 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune cells (such as T cells) comprising an anti-CD33 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: In a medical image generation method, projection data of a scanned object is acquired during rotation of a radiographic source, and a scout image of the scanned object is generated in one scanning direction using corresponding projection data in two opposite scanning directions in the projection data. The scanning direction is used to represent a relative position relationship between the radiographic source and the scanned object. Using projection data in two opposite directions to generate a scout image in one direction during rotary scanning of a radiographic source can significantly shorten the generation time of the scout image.

Abstract: Provided are single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune effector cells (such as T cells) comprising an anti-CLL1 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: A method and apparatus for image processing. An image scaling circuit is configured to receive image data for a plurality of pixels corresponding to a first image. The image data includes color information and a transparency value for each of the plurality of pixels. The image scaling circuit updates the image data by selectively changing the color information for one or more of the pixels based at least in part on the transparency values. In updating the image data, the image scaling circuit may determine contextual information about the first image based at least in part on the transparency values. The image scaling circuit further generates an interpolated image based on the updated image data for the plurality of pixels. For example, the interpolated image may be a scaled version of the first image.

Abstract: This application relates to a method and an apparatus for processing encoded data, a computer device, and a storage medium. The method includes: obtaining a to-be-encoded data frame; determining a complexity of the to-be-encoded data frame, the complexity representing at least a spatial texture complexity and a temporal motion intensity; obtaining a real-time encoding bit rate, the real-time encoding bit rate being an encoding bit rate of a previous encoded data frame of the to-be-encoded data frame; and adjusting an encoding parameter according to the real-time encoding bit rate and the complexity of the to-be-encoded data frame. The encoding parameter is adjusted according to the real-time encoding bit rate and the complexity, and different real-time encoding bit rates and complexities may correspond to different encoding parameters. In this way, the encoding parameter is applicable to different scenes, thereby achieving high adaptability.

Abstract: The present invention relates to a GPR84 receptor antagonist and use thereof. The GPR84 receptor antagonist of the present invention has a structure as represented by formula (I), the definitions of R1, R2, R3, R4, L1, L2, L3, L4, L5, L6, Y, Z, and rings A, B, C, and D are as described in the description and claims. The GPR84 receptor antagonist of the present invention can competitively inhibit the activation of the receptor caused by an agonist of GPR84, and can be used in the preparation of a medicament for treating related diseases caused by high expression or high excitability of GPR84 receptor, the diseases including multiple sclerosis, inflammatory bowel disease, arthritis and the like.

Abstract: Provided are a display panel and a display device. The display panel includes a fingerprint identification module, a light-blocking layer, a light-emitting device layer and a touch function layer which are sequentially stacked, where the light-blocking layer includes a plurality of imaging apertures; and the touch function layer includes a plurality of first touch areas and a plurality of second touch areas. The plurality of first touch areas do not overlap with imaging aperture identification areas, and the plurality of second touch areas overlap with at least one of the imaging aperture identification areas. Reflectivity of the second touch area is smaller than reflectivity of the first touch area; or transmittance of the second touch area is greater than transmittance of the first touch area; or light transmission uniformity of the second touch area is greater than light transmission uniformity of the first touch area.

Abstract: Disclosed herein are system, method, and computer program product embodiments for tracking shop information using blockchain. In an embodiment, a shop application system may gather information related to a shop using various sensors within the shop. For example, the shop application system may identify a flow rate of traffic within the shop or outside of the shop. The shop application system may securely transmit this information to a blockchain cloud platform to be stored onto a blockchain. The blockchain may also maintain store information from a client application system related to shop ownership or tenancy. In this manner, the blockchain may provide a public means for accessing transactions related to a shop as well as provide confidence in the information provided.

Abstract: An anode for generating ozone by electrolysis of water, a preparation method and use thereof, an ozone generating system, and a dental scaler are provided. The anode includes a titanium substrate and a composite oxide layer attached to a surface of the titanium substrate. The composite oxide layer is made of a metal oxide. Metal elements in the metal oxide comprise tin, ruthenium, manganese, titanium, and nickel, and a molar ratio of tin, ruthenium, manganese, titanium, and nickel is (200-500):(2.5-20):1:(1.5-7):(5-15).

Abstract: The present disclosure provides a dimmer and a manufacturing method thereof, a backlight unit and a display device. The dimmer includes at least one brightness adjusting unit. Each brightness adjusting unit includes a reflective layer and an electrochromic layer stacked over each other, and the electrochromic layer is configured to be reversibly switchable between a transparent state and a color rendering state.

Abstract: A method of monitoring activity capabilities of a subject, including determining sensor data for each of a plurality of sensors, the sensors being positioned within a living environment of the subject and the sensor data being indicative of activities performed by the subject; for each of a plurality of activity domains, determining a domain score indicative of a level of activity within the respective activity domain, the domain score being determined using sensor data from a respective combination of sensors within the respective domain; determining a reference activity level using reference domain scores during a reference time period; determining a current activity level using current domain scores during a monitoring time period; and generating an activity indicator in accordance with the current activity level and the reference activity level, the activity indicator being indicative of differences between the current activity level and the reference activity level, thereby providing feedback on the acti

Abstract: A method for encasing underground electrical cables, includes (a) providing a fresh concrete composition including a paste that includes a hydraulic binder, a mineral addition and water, the paste being present in a mixture with sand and aggregates, whereby the paste is present in the concrete composition in a volume of <320 L/m3 and/or the solid volume fraction of said paste is >50 vol.-% and (b) placing the fresh concrete composition so as to encase the underground cables therewith.

Abstract: The present invention relates to TrkB binding agonists, and to the use of such agonists in the treatment of neurological disorders and other disorders. The present invention also relates to specific TrkB binding agonists comprising CDRs, variable regions, heavy and light chains, and variant sequences thereof.

Abstract: Embodiments of the present disclosure provide a display panel and a display device. The display panel includes a retroreflective layer disposed on a light-emitting side, wherein the retroreflective layer includes a retroreflective region and a transmissive region, the retroreflective region is configured to reflect light irradiated on the retroreflective region along an opposite direction of an incident direction or close to the opposite direction of the incident direction; the display panel comprises a pixel region and a pixel define region for defining the pixel region, and the pixel region is at least partially overlapped with the transmissive region along a thickness direction of the display panel.

Abstract: A touch substrate and a method for manufacturing the same, a display panel and a display device. The touch substrate includes a first substrate, and a black matrix and a touch electrode layer on the first substrate. The black matrix defines an effective display area. An orthographic projection of the effective display area on the first substrate coincides with an orthographic projection of the touch electrode layer on the first substrate.

Abstract: Provided are a display panel, a preparation method thereof and a display device. The display panel includes a light-emitting substrate and a color filter substrate; the color filter substrate includes: a substrate, a baffle wall layer and a reflective metal layer. The baffle wall layer is located on one side of the substrate and includes multiple baffle wall structures; the reflective metal layer includes a first reflective subsection covering a surface on a side, close to the light-emitting substrate, of the multiple baffle wall structures; the first reflective subsection includes multiple first metal subsections and multiple second metal subsections; and the multiple first metal subsections are independently disposed, and adjacent ones of the multiple second metal subsections along the first direction are connected to each other.

Abstract: This application provides an image aesthetic processing method and an electronic device. A method for generating an image aesthetic scoring model includes: constructing a first neural network based on a preset convolutional structure set; obtaining an image classification neural network, where the image classification neural network is used to classify image scenarios; obtaining a second neural network based on the first neural network and the image classification neural network, where the second neural network is a neural network containing scenario information; and determining an image aesthetic scoring model based on the second neural network, where output information of the image aesthetic scoring model includes image scenario classification information. In this method, scenario information is integrated into a backbone neural network, so that a resulting image aesthetic scoring model is interpretable.

Abstract: Application of glutamate dehydrogenase GdhA of Peptostreptococcus asaccharolyticus in increasing the yield of poly-?-glutamic acid from Bacillus licheniformis. The glutamate dehydrogenase GdhA of the Bacillus licheniformis WX-02 per se is replaced with the glutamate dehydrogenase derived from the Peptostreptococcus asaccharolyticus by means of homologous recombination, which significantly increases the level of synthesizing the poly-?-glutamic acid for the Bacillus licheniformis, and the yield of the obtained poly-?-glutamic acid from strains is increased at least by more than 20% compared with control strains.

Abstract: A socket testing method comprises obtaining a raw socket image, performing binarization on the raw socket image to generate a binarized socket image, determining a plurality of pinhead locations in the binarized socket image, applying a grid with the grid including a plurality of intersections to the binarized socket image, for each of the plurality of pinhead locations, obtaining the distance between the pinhead location and one of the plurality of intersections which is nearest to the pinhead location, and outputting a warning signal associated with the pinhead location when determining that the distance is larger than a tolerance value.

Abstract: An optical film, a color filter substrate, manufacturing methods thereof and display devices are provided, in the field of liquid crystal display technology. The color filter substrate includes a base, a color resistant layer and a diffusion layer. The color resistant layer and the diffusion layer are arranged on the base, and the color resistant layer and the base are arranged at the same side of the diffusion layer. The color resistant layer comprises a plurality of color resistant blocks which are arranged in an array. The diffusion layer comprises a plurality of diffusion structures which are arranged to be in one-to-one correspondence to the plurality of color resistant blocks. Each of the plurality of diffusion structures is configured to diffuse light vertically emitted from the color filter substrate.