Patents by Inventor Qingbo Li
Qingbo Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230176436Abstract: A liquid crystal writing apparatus and corresponding method for implementing local erasure by using light, the apparatus includes: a conductive layer, a bistable liquid crystal layer, and a base layer that are sequentially arranged. The base layer is integrated with: a plurality of erasing units arranged in an array, where an erasing electrode and a thin film transistor (TFT) connected to the erasing electrode are disposed in each erasing unit; at least one first conducting wire configured to supply a control voltage to gate of each TFT; and at least one second conducting wire configured to supply an input voltage to source of each TFT, where the TFT is configured to be in a critical cut off state, and then be turned on by receiving light of a set intensity, to input a set voltage to a corresponding erasing electrode.Type: ApplicationFiled: July 27, 2021Publication date: June 8, 2023Applicant: SHANDONG LANBEISITE EDUCATIONAL EQUIPMENT GROUPInventors: Qingbo LI, Mengxun YANG
-
Patent number: 11137899Abstract: A liquid crystal writing film includes: a first conductive layer, a liquid crystal layer and a second conductive layer, which are arranged in sequence. At least one of the first conductive layer and the second conductive layer is divided into two or more conductive regions that are insulated from each other; and the positioning of a to-be-erased region is achieved by the positioning system, a set voltage is applied to the set conductive region, and the voltage forms a set electric field in the to-be-erased region to erase the to-be-erased region. According to the present invention, the partial erasing of the liquid crystal writing film can be realized by using a local electric field formed between two upper and lower conductive layers, the erasing speed is high, a partial erasing region can be accurately positioned, and meanwhile the storage and reproduction of a writing trajectory can be achieved.Type: GrantFiled: January 10, 2019Date of Patent: October 5, 2021Assignee: SHANDONG LANBEISITE EDUCATIONAL EQUIPMENT GROUPInventors: Qingbo Li, Xinli Shi
-
Publication number: 20200142581Abstract: A liquid crystal writing film includes: a first conductive layer, a liquid crystal layer and a second conductive layer, which are arranged in sequence. At least one of the first conductive layer and the second conductive layer is divided into two or more conductive regions that are insulated from each other; and the positioning of a to-be-erased region is achieved by the positioning system, a set voltage is applied to the set conductive region, and the voltage forms a set electric field in the to-be-erased region to erase the to-be-erased region. According to the present invention, the partial erasing of the liquid crystal writing film can be realized by using a local electric field formed between two upper and lower conductive layers, the erasing speed is high, a partial erasing region can be accurately positioned, and meanwhile the storage and reproduction of a writing trajectory can be achieved.Type: ApplicationFiled: January 10, 2019Publication date: May 7, 2020Applicant: SHANDONG LANBEISITE EDUCATIONAL EQUIPMENT GROUPInventors: Qingbo LI, Xinli SHI
-
Publication number: 20170188974Abstract: A statistical system is disclosed to analyze multivariate response of circadian rhythms in a crossover design, in which response variables are continuously monitored to evaluate the therapeutic effect of a regimen on circadian rhythms such as blood pressure and blood sugar. The methods determine the alteration of not only amplitude but also correlation of multiple circadian rhythms under the influence of a regimen.Type: ApplicationFiled: February 3, 2015Publication date: July 6, 2017Inventor: Qingbo Li
-
Patent number: 8078025Abstract: The invention discloses a vehicle dynamic measurement device for comprehensive parameters of rail wear, which comprises a vision sensor, a computer and a milometer. A high-speed image acquisition card and a measurement module are installed in the computer. The vision sensor comprises imaging system for rail cross-section and a raster projector which can project more than one light plane perpendicular to the measured rail. The measurement module is used for calculating vertical wear, horizontal wear, the amplitude and wavelength of corrugation wear. The invention also discloses a vehicle dynamic measurement method for comprehensive parameters of rail wear. The invention can increase the sampling rate of image sensing and acquisition hardware equipment with no need of improving the performance of it, thereby satisfy high-speed on-line dynamic measurement requirements for corrugation wear, and the amplitude and wavelength of corrugation wear can be calculated more precisely.Type: GrantFiled: October 25, 2008Date of Patent: December 13, 2011Assignee: Beihang UniversityInventors: Guangjun Zhang, Junhua Sun, Zhenzhong Wei, Fuqiang Zhou, Qingbo Li, Zhen Liu, Qianzhe Liu
-
Publication number: 20110220508Abstract: An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends is spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.Type: ApplicationFiled: March 15, 2011Publication date: September 15, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Changsheng LIU, Thomas E. KANE, Qingbo LI
-
Publication number: 20100147692Abstract: An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends is spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.Type: ApplicationFiled: December 9, 2009Publication date: June 17, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Changsheng Liu, Thomas E. Kane, Qingbo Li
-
Patent number: 7697976Abstract: The invention relates to a non-invasive method to diagnose the changes of molecular structures of organism tissues from body surface and a dedicated apparatus. The apparatus is comprised of a Fourier Transform infrared spectrometer and a set of additional accessories. Said additional accessories include a mid-IR fiber optics sampling attachment, a fiber coupling part, and an infrared detector part. The detection method is comprised of placing the ATR probe of the dedicated apparatus on the skin surface of a region to be tested, and scanning more than one time in which the resolution of the apparatus is 1-32 cm?1 and the range of the spectrum is 800-4000 cm?1. It is possible to detect changes in molecular structures of living biological tissues in the early stages of cancer, and testees will not feel uncomfortable during testing. The method is easy to operate, quick, accurate, and it doesn't harm the body.Type: GrantFiled: January 18, 2005Date of Patent: April 13, 2010Assignees: Peking University, Beijing Second Optical InstrumentFacotryInventors: Jinguang Wu, Yuanfu Zhang, Yizhuang Xu, Qingbo Li, Shifu Weng, Limin Yang, Li Zhang, Weijin Zhou, Zhanlan Yang, Weihong Li, Huizhong Wu, Rongye Gong, Xuejun Gao, Duanfu Xu, Ying Zhao, Zhi Xu, Nengwei Zhang, Lixin Wang, Kaihua Sun, Xin Peng, Yufeng Liu, Xuejun Sun, Xiaofeng Ling, Su Zhou, Zhi Liu, Guoqiao Lai, Jianxiong Jiang, Qinghua Pan, Qiguang Wu, Guangyan Yu, Bingbing Wang
-
Publication number: 20100051459Abstract: The present invention relates to a method of separating a sample comprising biological compounds, such as nucleic acids. The nucleic acids are subjected to electrophoresis using a matrix that is essentially free of denaturants and having at least one random, linear copolymer comprising a first comonomer of acrylamide and at least one secondary comonomer. A temperature of at least a portion of the matrix is at least about 80° C.Type: ApplicationFiled: January 6, 2009Publication date: March 4, 2010Inventors: Qingbo Li, Kevin J. Levan, Heide Monroe
-
Publication number: 20090112487Abstract: The invention discloses a vehicle dynamic measurement device for comprehensive parameters of rail wear, which comprises a vision sensor, a computer and a milometer. A high-speed image acquisition card and a measurement module are installed in the computer. The vision sensor comprises imaging system for rail cross-section and a raster projector which can project more than one light plane perpendicular to the measured rail. The measurement module is used for calculating vertical wear, horizontal wear, the amplitude and wavelength of corrugation wear. The invention also discloses a vehicle dynamic measurement method for comprehensive parameters of rail wear. The invention can increase the sampling rate of image sensing and acquisition hardware equipment with no need of improving the performance of it, thereby satisfy high-speed on-line dynamic measurement requirements for corrugation wear, and the amplitude and wavelength of corrugation wear can be calculated more precisely.Type: ApplicationFiled: October 25, 2008Publication date: April 30, 2009Applicant: BEIHANG UNIVERSITYInventors: Guangjun Zhang, Junhua Sun, Zhenzhong Wei, Fuqiang Zhou, Qingbo Li, Zhen Liu, Qianzhe Liu
-
Publication number: 20090090630Abstract: An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends is spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresed into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.Type: ApplicationFiled: October 27, 2008Publication date: April 9, 2009Inventors: Changsheng Liu, Thomas E. Kane, Qingbo Li
-
Patent number: 7473341Abstract: The present invention relates to a method of separating a sample comprising biological compounds, such as nucleic acids. The nucleic acids are subjected to electrophoresis using a matrix that is essentially free of denaturants and having at least one random, linear copolymer comprising a first comonomer of acrylamide and at least one secondary comonomer. A temperature of at least a portion of the matrix is at least about 80° C.Type: GrantFiled: September 15, 2003Date of Patent: January 6, 2009Assignee: Applera CorporationInventors: Qingbo Li, Kevin J. Levan, Heidi Monroe
-
Patent number: 7459070Abstract: An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.Type: GrantFiled: August 15, 2005Date of Patent: December 2, 2008Assignee: Applied Biosystems Inc.Inventors: Changsheng Liu, Thomas E. Kane, Qingbo Li
-
Publication number: 20080228083Abstract: The invention relates to a non-invasive method to diagnose the changes of molecular structures of organism tissues from body surface and a dedicated apparatus. The apparatus is comprised of a Fourier Transform infrared spectrometer and a set of additional accessories. Said additional accessories include a mid-IR fiber optics sampling attachment, a fiber coupling part, and an infrared detector part. The detection method is comprised of placing the ATR probe of the dedicated apparatus on the skin surface of a region to be tested, and scanning more than one time in which the resolution of the apparatus is 1-32 cm?1 and the range of the spectrum is 800-4000 cm?1. It is possible to detect changes in molecular structures of living biological tissues in the early stages of cancer, and testees will not feel uncomfortable during testing. The method is easy to operate, quick, accurate, and it doesn't harm the body.Type: ApplicationFiled: January 18, 2005Publication date: September 18, 2008Inventors: Jinguang Wu, Yuanfu Zhang, Yizhuang Xu, Qingbo Li, Shifu Weng, Limin Yang, Li Zhang, Weijin Zhou, Zhanian Yang, Weihong Li, Huizhong Wu, Rongye Gong, Xuejun Gao, Duanfu Xu, Ying Zhao, Zhi Xu, Nengwei Zhang, Lixin Wang, Kaihua Sun, Xin Peng, Yufeng Liu, Xuejun Sun, Xiaofeng Ling, Su Zhou, Zhi Liu, Guoqiao Lai, Jianxiong Jiang, Qinghua Pan, Qiguang Wu, Guangyan Yu, Bingbing Wang
-
Patent number: 7329333Abstract: A capillary electrophoresis system comprises capillaries positioned in parallel to each other forming a plane. The capillaries are configured to allow samples to migrate. A light source is configured to illuminate the capillaries and the samples therein. This causes the samples to emit light. A lens is configured to receive the light emitted by the samples and positioned directly over a first group of the capillaries and obliquely over a second group of the capillaries. The light source is further configured to illuminate the second group of capillaries more than the first group of the capillaries such that amount of light received by the lens from the first group of capillaries is substantially identical to amount of light received from the second group of capillaries when an identical amount of the samples is migrating through the first and second group capillaries.Type: GrantFiled: October 7, 2003Date of Patent: February 12, 2008Assignee: Applera CorporationInventors: Qingbo Li, Songsan Zhou, Changsheng Liu
-
Patent number: 7175750Abstract: The present invention relates to a method for determining the presence of a mutation in a first sample comprising first nucleotides. The reference sample comprising reference nucleotides. The first sample and a reference sample are subjected to electrophoresis in the presence of at least one intercalating dye. During electrophoresis the temperature of the first sample and the reference sample is changed by an amount sufficient to change an electrophoretic mobility of at least one of the first or reference nucleotides. Fluorescence intensity data are obtained. The fluorescence intensity data are indicative of the presence of the first and reference nucleotides. At least one of the first sample or reference samples comprises products resulting from a polymerase chain reaction (PCR), the products not having been desalted prior to electrophoresis.Type: GrantFiled: November 5, 2002Date of Patent: February 13, 2007Assignee: SpectruMedix LLCInventors: Zhiyong Guo, Zhaowei Liu, Qingbo Li
-
Publication number: 20060091011Abstract: An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.Type: ApplicationFiled: August 15, 2005Publication date: May 4, 2006Inventors: Changsheng Liu, Thomas Kane, Qingbo Li
-
Patent number: 6953521Abstract: An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.Type: GrantFiled: December 11, 2001Date of Patent: October 11, 2005Assignee: SpectruMedix LLCInventors: Changsheng Liu, Thomas E Kane, Qingbo Li
-
Patent number: 6926815Abstract: This invention relates to an electrophoresis separation medium having a gel matrix of at least one random, linear copolymer comprising a primary comonomer and at least one secondary comonomer, wherein the comonomers are randomly distributed along the copolymer chain. The primary comonomer is an acrylamide or an acrylamide derivative that provides the primary physical, chemical, and sieving properties of the gel matrix. The at least one secondary comonomer imparts an inherent physical, chemical, or sieving property to the copolymer chain. The primary and secondary comonomers are present in a ratio sufficient to induce desired properties that optimize electrophoresis performance. The invention also relates to a method of separating a mixture of biological molecules using this gel matrix, a method of preparing the novel electrophoresis separation medium, and a capillary tube filled with the electrophoresis separation medium.Type: GrantFiled: April 30, 2001Date of Patent: August 9, 2005Assignee: SpectruMedix LLCInventors: Changsheng Liu, Qingbo Li
-
Publication number: 20050064400Abstract: The present invention relates to a method for determining the presence of a mutation in a first sample comprising first polynucleotides. The reference sample comprises reference polynucleotides. The first sample and a reference sample are subjected to electrophoresis in the presence of at least one intercalating dye. During electrophoresis the temperature of the first sample and the reference sample is changed by an amount sufficient to change an electrophoretic mobility of at least one of the first or reference polynucleotides. Fluorescence intensity data are obtained. The fluorescence intensity data are indicative of the presence of the first and reference polynucleotides. The data are processed to determine the presence of mutation in the first polynucleotides.Type: ApplicationFiled: November 5, 2002Publication date: March 24, 2005Inventors: Zhiyong Guo, Zhaowei Liu, Qingbo Li