Abstract: A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. The Linker is or and n is 1-6.

Abstract: A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. In formula I and II, n is 1-6.

Abstract: A process for preparing a TPU alloy material through in-situ compatibilization includes: 1) adding a premixed TPU raw material to a feeding port of a twin-screw extruder; injecting a mixture of an alloy component and a dual-active substance into the twin-screw extruder through a lateral feeding port; adding an auxiliary reagent to the TPU raw material or the mixture of the alloy component and the dual-active substance, wherein the alloy component is a polyolefin or a thermoplastic polymer material having reactivity, wherein the dual-active substance is a substance containing a group reactive with the TPU raw material and a group reactive with the alloy component, and the auxiliary reagent includes an initiator; 2) controlling a temperature of a reaction zone of the twin-screw extruder at 50° C. to 250° C., and granulating an extruded material by underwater cutting; and 3) drying the granulated product to obtain the TPU alloy material.

Abstract: A process for preparing a TPU alloy material through in-situ compatibilization includes: 1) adding a premixed TPU raw material to a feeding port of a twin-screw extruder; injecting a mixture of an alloy component and a dual-active substance into the twin-screw extruder through a lateral feeding port; adding an auxiliary reagent to the TPU raw material or the mixture of the alloy component and the dual-active substance, wherein the alloy component is a polyolefin or a thermoplastic polymer material having reactivity, wherein the dual-active substance is a substance containing a group reactive with the TPU raw material and a group reactive with the alloy component, and the auxiliary reagent includes an initiator; 2) controlling a temperature of a reaction zone of the twin-screw extruder at 50° C. to 250° C., and granulating an extruded material by underwater cutting; and 3) drying the granulated product to obtain the TPU alloy material.

Abstract: Disclosed is a software application reliability and availability tracking and reporting mechanism that collects event data from target computers, analyzes the data, and produces reliability and availability reports. A network administrator specifies target computers for which event data are collected. The collected event data along with a reliability model are provided to a reliability and availability analysis engine. Output from the engine includes reliability and availability data expressed as durations of time spent in each state and as associations with the events. The reliability and availability data are fed to a report generator which computes reliability and availability metrics. The metrics are used to generate reports that can be interpreted by the network administrator without the need for specialized data analysis skills.

Abstract: Disclosed is a software application reliability and availability tracking and reporting mechanism that collects event data from target computers, analyzes the data, and produces reliability and availability reports. A network administrator specifies target computers for which event data are collected. The collected event data along with a reliability model are provided to a reliability and availability analysis engine. Output from the engine includes reliability and availability data expressed as durations of time spent in each state and as associations with the events. The reliability and availability data are fed to a report generator which computes reliability and availability metrics. The metrics are used to generate reports that can be interpreted by the network administrator without the need for specialized data analysis skills.