Patents by Inventor Qingchai Xu

Qingchai Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for inverse solid phase synthesis of peptides
    Publication number: 20080200644
    Abstract: The present invention provides a process for preparing a peptide of formula (I): Sub-[L]-[NH-A-C(O)]n+m—OH ??(I) comprising: (a) reacting an immobilized compound of formula (II): Sub-(L)-[NH-A-C(O)]n—OH ??(II) with an amino acid ester or peptide derivative of formula (III): H—[NH-A-C(O)]m—O(tBu) ??(III) in the presence of a coupling agent to yield a peptide compound of general formula (IV): Sub-[L]-[NH-A-C(O)]n+m—O(tBu); ??(IV) (b) removing the tBu (t-butyl) group to produce a solid-support bound carboxylic acid or peptide derivative of general formula (I); wherein n is a positive integer, e.g., 1-10, preferably 1-5; m is a positive integer.
    Type: Application
    Filed: April 24, 2007
    Publication date: August 21, 2008
    Inventors: William G. Gutheil, Qingchai Xu
  • Method for inverse solid phase synthesis of peptides
    Patent number: 7214769
    Abstract: The present invention provides a process for preparing a peptide of formula (I): Sub-[L]-[NH-A-C(O)]n+m—OH??(I) comprising: (a) reacting an immobilized compound of formula (II): Sub-(L)-[NH-A-C(O)]n—OH??(II) ?with an amino acid ester or peptide derivative of formula (III): H—[NH-A-C(O)]m—O(tBu)??(III) ?in the presence of a coupling agent to yield a peptide compound of general formula (IV): Sub-[L]-[NH-A-C(O)]n+m—O(tBu);??(IV) (b) removing the tBu (t-butyl) group to produce a solid-support bound carboxylic acid or peptide derivative of general formula (I); wherein n is a positive integer, e.g., 1-10, preferably 1-5; m is a positive integer.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: May 8, 2007
    Assignee: The Curators of the University of Missouri
    Inventors: William G. Gutheil, Qingchai Xu
  • Preparation and application of ligand-biopolymer conjugates
    Publication number: 20040235027
    Abstract: The present invention provides methods for the site-specific attachment of ligands to a biopolymer. These methods are suitable for microarray construction, biodegradable scaffold formation, cell or tissue growth, as well as the conjugates or products formed by those methods.
    Type: Application
    Filed: March 31, 2004
    Publication date: November 25, 2004
    Applicant: Regent of the University of California
    Inventors: Kit S. Lam, Qingchai Xu
  • Method for inverse solid phase synthesis of peptides
    Publication number: 20030027982
    Abstract: The present invention provides a process for preparing a peptide of formula (I):
    Type: Application
    Filed: May 23, 2002
    Publication date: February 6, 2003
    Inventors: William G. Gutheil, Qingchai Xu