Patents by Inventor Qingdan Yao

Qingdan Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sitagliptin intermediates, preparation methods and uses thereof
    Patent number: 8471057
    Abstract: The present invention relates to Sitagliptin intermediate and preparation method and use thereof. The method comprises reacting compound of formula (II) and trifluorobromobenzene with a Grignard reagent by a Grignard reaction to obtain a compound of formula (I). Compound of formula (I) is a new intermediate compound for the synthesis of Sitagliptin. Compound of formula (I) can be easily used for preparing another important intermediate compound of formula (V) for the synthesis of Sitagliptin.
    Type: Grant
    Filed: September 25, 2010
    Date of Patent: June 25, 2013
    Assignee: Zhejiang Jiuzhou Pharmaceutical Co., Ltd.
    Inventors: Guoliang Zhu, Jian Zhang, Lijun Yang, Qingdan Yao, Jie Ying
  • SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF
    Publication number: 20120178957
    Abstract: The present invention relates to Sitagliptin intermediate and preparation method and use thereof. The method comprises reacting compound of formula (II) and trifluorobromobenzene with a Grignard reagent by a Grignard reaction to obtain a compound of formula (I). Compound of formula (I) is a new intermediate compound for the synthesis of Sitagliptin. Compound of formula (I) can be easily used for preparing another important intermediate compound of formula (V) for the synthesis of Sitagliptin.
    Type: Application
    Filed: September 25, 2010
    Publication date: July 12, 2012
    Inventors: Guoliang Zhu, Jian Zhang, Lljun Yang, Qingdan Yao, Jie Ying