Abstract: The present invention relates to isolated and engineered human antibodies that specifically bind to at least one conformational (non-linear) epitope of HBsAg and neutralize hepatitis B virus infection, methods for producing the same, and uses thereof in treating human HBV infection.

Abstract: Generation of chimeric non-human animals hosting bat donor cells involves chimeric mice having bat cells that may be stably tolerated to provide a new platform technology in the general field of biology, and having application in the field of immunology related to virus-host interaction, cancer biology, autoimmunity, and the development of new drugs.

Abstract: Disclosed herein is a nanoparticle composition comprising nanoparticles formed from one of: a conjugate of dimeric epigallocatechin-3-O-gallate and hyaluronic acid; a conjugate of epigallocatechin-3-O-gallate and hyaluronic acid; or a epigallocate-chin-3-O-gallate-terminated hyaluronic acid conjugate; and an active agent or a pharmaceutically acceptable salt, solvate or prodrug 0thereof suitable to treat acute myeloid leukaemia, wherein the active agent is encapsulated in the nanoparticles.

Abstract: Generation of chimeric non-human animals hosting bat donor cells involves chimeric mice having bat cells that may be stably tolerated to provide a new platform technology in the general field of biology, and having application in the field of immunology related to virus-host interaction, cancer biology, autoimmunity, and the development of new drugs.

Abstract: This invention refers to a mouse for human hepatitis studies wherein the mouse has been injected with CD34+ stem cells and wherein the mouse is immunocompromised, as well as a method of manufacturing a mouse model comprising administering CD34+ stem cells as defined herein into an immunocompromised mouse as defined herein. The invention also refers to the use of a mouse as defined for testing the efficiency of putative anti-HBV or anti-HCV drugs or for characterizing changes in viral quasispecies during HBV or HCV infection.

Abstract: The invention is directed to a method of determining whether an agent causes immune toxicity in a human comprising administering the agent to a non-human mammal that has been engrafted with human hematopoietic stem cells (HSCs) and administered one or more human cytokines; and determining whether the agent causes immune toxicity in the non-human mammal. If the agent causes immune toxicity in the non-human mammal then the agent causes toxicity in a human. The invention is also directed to a method of determining whether administration of an agent causes cytokine release syndrome in an individual in need thereof comprising administering the agent to a non-human mammal that has been engrafted with HSCs and administered one or more human cytokines; and determining whether the agent causes cytokine release syndrome in the non-human mammal. If the agent causes cytokine release syndrome in the non-human mammal then the agent will cause cytokine release syndrome in the human.

Abstract: The embodiments of the present invention disclose a method, a device, and a system for controlling multichannel cascade between two media control servers. The method comprises: receiving a service request message; choosing a target channel among all the channels multichannel-cascaded with an opposite cascaded media control server according to the service request message and a preset channel usage rule; and sending information about the determined target channel to the opposite cascaded media control server so as to enable the opposite cascaded media control server to carry out code stream switching according to the information about the target channel. The method disclosed in the embodiments of the present invention saves cascaded channels and improves the utilization of cascaded channels, thereby saving channel resources.

Abstract: Provided herein are methods of reconstituting functional human blood cell lineages in a non-human mammal comprising introducing human hematopoietic stem cells (HSCs) and nucleic acid encoding one or more human cytokines into an immunodeficient non-human mammal. The non-human mammal is maintained under conditions in which the nucleic acid is expressed and the human HSCs differentiate into functional human blood cell lineages in the non-human mammal, thereby reconstituting functional human blood cell lineages in the non-human mammal. Also provided are methods of producing human antibodies directed against an immunogen in a non-human mammal, hybridomas that secrete the monoclonal antibodies as well as antibodies (e.g., polyclonal antibodies; monoclonal antibodies) produced by the B cells and non-human mammals produced by the methods.

Abstract: The embodiments of the present invention disclose a method, a device, and a system for controlling multichannel cascade between two media control servers. The method comprises: receiving a service request message; choosing a target channel among all the channels multichannel-cascaded with an opposite cascaded media control server according to the service request message and a preset channel usage rule; and sending information about the determined target channel to the opposite cascaded media control server so as to enable the opposite cascaded media control server to carry out code stream switching according to the information about the target channel. The method disclosed in the embodiments of the present invention saves cascaded channels and improves the utilization of cascaded channels, thereby saving channel resources.