Abstract: Provided are salts of a compound of formula (I) having an ATX inhibitory activity. The salts comprises inorganic acid salts or organic acid salts, and solid forms of the salts, such as crystal forms. The salts of the compound of formula (I) and their crystal forms according to the present disclosure have a good solubility, stability and hygroscopicity, and are more suitable for medicinal use. Moreover, their preparation methods are simple and convenient, and are suitable for large-scale production.

Abstract: The present invention relates to a polyvalent pneumococcal polysaccharide protein conjugate and immunogenicity thereof, and specifically provides an immunogenic composition containing capsular polysaccharides of Streptococcus pneumoniae from different serotypes, and a carrier, the serotypes at least comprising 2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20, 22F and 33F. The immunogenic composition can improve the immunogenicity of polysaccharides of different serotypes, and may prevent invasive infection caused by pneumococci of various different serotypes.

Abstract: The present disclosure provides a power filter. The power filter may include an overvoltage protection circuit and an LC filter circuit connected to the overvoltage protection circuit, wherein the overvoltage protection circuit includes a voltage regulator and a peak compensation circuit. The peak compensation circuit is configured to generate a gain peak at a resonance frequency of the LC filter circuit, so as to compensate for a gain dip at the voltage regulator stage occurring at the resonance frequency of the LC filter circuit.

Abstract: The present disclosure discloses a method for purifying tetanus toxin or variants thereof. The method for purifying tetanus toxin or variants thereof uses metal chelate affinity chromatography, and the tetanus toxin does not contain an affinity tag. The present disclosure uses biocompatible agarose-based nickel affinity chromatography and anion exchange chromatography as separation subjects, which can quickly and effectively remove impure proteins and enrich target proteins; it improves the separation and purification efficiency of proteins and greatly reduces the loss of proteins.

Abstract: The present invention relates to a P2X3 inhibitor compound, a salt thereof, a polymorph thereof and use thereof. The present invention provides a crystalline form of a compound of formula I, which has good medicinal properties. A pharmaceutically acceptable salt of the compound of formula I is also obtained, and a crystalline form product of the salt is further obtained, such as a hydrochloride crystalline form A, a maleate crystalline form A, a p-toluenesulfonate crystalline form A, a benzenesulfonate crystalline form A, or a malonate crystalline form A. The present invention has great significance for developing effective therapeutic drugs.

Abstract: An EP4 antagonist represented by formula I, which specifically comprises a crystal form thereof, a pharmaceutically acceptable salt or crystal form thereof, a preparation method therefor, a composition containing same, and a medical use of a related compound.

Abstract: Embodiments are disclosed for a compensating circuit for a boost circuit that outputs a voltage that is a function of a voltage signal. In one or more examples, the compensation circuit may include a gain that is adjustable in proportion to voltage output of the boost circuit and inversely proportionate to input current to the boost circuit.

Abstract: Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.

Abstract: Provided are salts of a compound of formula (I) having an ATX inhibitory activity. The salts comprises inorganic acid salts or organic acid salts, and solid forms of the salts, such as crystal forms. The salts of the compound of formula (I) and their crystal forms according to the present disclosure have a good solubility, stability and hygroscopicity, and are more suitable for medicinal use. Moreover, their preparation methods are simple and convenient, and are suitable for large-scale production.

Abstract: The present disclosure provides a power filter. The power filter may include an overvoltage protection circuit and an LC filter circuit connected to the overvoltage protection circuit, wherein the overvoltage protection circuit includes a voltage regulator and a peak compensation circuit. The peak compensation circuit is configured to generate a gain peak at a resonance frequency of the LC filter circuit, so as to compensate for a gain dip at the voltage regulator stage occurring at the resonance frequency of the LC filter circuit.

Abstract: The invention relates to a rod-shaped cooking machine, which includes a rod-shaped hollow housing. The top of the housing is provided with a touch screen assembly, the bottom of the housing is provided with a bottom cover. Inside the housing, a main PCB plate is arranged near the touch screen assembly, a heating assembly is arranged near the bottom cover, a stirring assembly is arranged between the main PCB plate and the heating assembly. The stirring assembly has a motor and a stirring rod set on the motor. The heating assembly has a plastic cylinder. The stirring rod reaches into the plastic cylinder cylinder; the middle part of the housing is provided with an inlet connecting the plastic cylinder, and the bottom cover is provided with a drain port connected to the plastic cylinder.