Abstract: The invention provides a transcription factor PfAP2-O5 inhibitor for Plasmodium falciparum, a pharmaceutical composition, and a drug for treating malaria resistant to artemisinin and an analog thereof. Disclosed in the present invention is new use of a triazoloquinoline derivative or a pharmaceutically acceptable salt or hydrate thereof. The triazoloquinoline derivative can inhibit the expression of an invasion gene pfap2-o5, block the invasion of Plasmodium falciparum into red blood cells, affect its growth and development, and achieve the effect of killing Plasmodium falciparum. Therefore, the triazoloquinoline derivative can be used as an inhibitor for pfap2-o5, a drug for inhibiting Plasmodium falciparum, or a drug for preventing or treating malaria.

Abstract: The disclosure belongs to the technical field of biomedicine, and specifically relates to an application of DHA@ZIF-8 in the treatment of experimental cerebral malaria. In the disclosure, an experimental cerebral malaria model is first established. Subsequently, DHA@ZIF-8 is used for treatment in the model, and the therapeutic efficacy of the nanodrug against experimental cerebral malaria is evaluated using behavioral, pathological, and molecular biological techniques. In the disclosure, the use of ZIF-8 as a carrier achieves the effect of slowly releasing the drug, prolonging the duration of action of the drug in vivo, so as to more effectively kill Plasmodium. Compared with natural administration, this approach extends the duration of action of DHA.

Abstract: The disclosure belongs to the technical field of biomedicine, and specifically relates to an application of Akkermansia muciniphila (AKK) in the amelioration and treatment of cerebral malaria caused by Plasmodium berghei. The disclosure aims to evaluate the efficacy of AKK alone or in combination with adjuvant drugs (dihydroartemisinin, rapamycin, and atorvastatin) in ameliorating and treating experimental cerebral malaria in an experimental cerebral malaria model. The results indicate that AKK, whether used alone or in combination with drugs, can effectively ameliorate behavioral deficits and immunopathological damage of each organ, lower parasitemia levels, and prolong survival period of mice. Compared with the use of drug alone, the combination therapy can effectively treat the experimental cerebral malaria. The disclosure is the first to propose the concept of bacterial-drug synergy concept, and provides a solution to the treatment of human cerebral malaria on the basis of the concept.

Abstract: The invention provides a transcription factor PfAP2-O5 inhibitor for Plasmodium falciparum, a pharmaceutical composition, and a drug for treating malaria resistant to artemisinin and an analog thereof. Disclosed in the present invention is new use of a hexahydroquinoline derivative or a pharmaceutically acceptable salt or hydrate thereof. The hexahydroquinoline derivative can inhibit the expression of an invasion gene pfap2-o5, block the invasion of Plasmodium falciparum into red blood cells, affect its growth and development, and achieve the effect of killing Plasmodium falciparum. Therefore, the hexahydroquinoline derivative can be used as an inhibitor for pfap2-o5, a drug for inhibiting Plasmodium falciparum, or a drug for preventing or treating malaria.

Abstract: The present disclosure relates to a method for imaging and an imaging system. The method includes obtaining a scanning protocol for an examination subject, which includes: obtaining calibration data associated with the scanning protocol in response to a commonly used scanning protocol calibration data set of a medical imaging system including the calibration data; or performing a calibration operation in response to a commonly used scanning protocol calibration data set of a medical imaging system not including calibration data associated with the scanning protocol, to generate calibration data associated with the scanning protocol. The method further includes scanning the examination subject based on the scanning protocol, to obtain raw imaging data, and performing reconstruction using the calibration data associated with the scanning protocol and the raw imaging data, to obtain a medical image of a scanned subject.

Abstract: A charging pile is provided, including: a charging unit and at least one air-cooled radiator arranged in a box; the box includes a first box and a second box, a protection level of the first box is higher than a protection level of the second box; the charging unit is arranged in the first box; an independent heat dissipation air duct is provided in the second box so that the charging unit dissipates heat through the heat dissipation air duct; and the charging unit is configured to charge an electrical equipment, thereby avoiding need to design a heat dissipation module for each power conversion module in the charging pile and then perform a secondary design of the heat dissipation air duct on the entire charging pile in the conventional technology, which reduces cost of the charging pile and improves a level of protection of the charging pile.

Abstract: The device and method for manufacturing metal clad strip continuously provided by the present invention, combines casting, rolling and heat treatment used for the single material manufacture with the continuous and large-scale manufacture method for the clad strip, greatly improves the productivity of clad strip. The present invention can be used for manufacturing single-sided or double-sided clad strips with different thickness specifications, wherein the base layer material or the clad layer material can be selected in a wide range, including carbon steel, stainless steel, special alloy steel, titanium, copper and the like. In the present application, continuous casting and rolling clad strip is implemented, which decrease the energy consumption and costs.

Abstract: A side spray method for cooling a steel strip after hot rolling includes providing side spray devices behind multiple cooling sections on two sides in a width direction of a run out roller table of the steel strip after hot rolling. The side spray devices are staggered along the two sides of the run out roller table of the steel strip, the side spray devices include at least two spray units, each spray unit includes a spray tube and nozzles on the spray tube, the spray tubes being in parallel and vertically arranged along a running direction of the steel strip, and being movable along the running direction of the steel strip, covering ranges of the nozzles on the side spray devices are partially overlapped with each other, and a total spray coverage covering of nozzles covers a width of the run out roller table of the steel strip.

Abstract: A production apparatus for short-process metal composite plate manufacturing, the apparatus including a metal supply device including an uncoiler (1), pinch roll (2), shot blasting machine (3), welding device (4), welding pinch roll (5), induction heating apparatus (6), metal delivery machine (7), two crystallization cooling rolls (8), secondary cooling leveling roll (9), rolling mill pinch roll (10), rolling mill (11), on-line cooling apparatus (12), straightener (13), and at least one of a dividing shear (14) and a recoiling machine (15). Also disclosed is a production method for short-process metal composite plate manufacturing. The apparatus and method combine continuous casting, rolling, and heat-treating means for single material production with continuous and large-scale production of composite plate strips, and production efficiency of composite plates is sharply improved.

Abstract: A device and method for achieving RNAi of insects by atomization are provided. The device includes an insect placing box installed on a chemical solution atomizer; a power plug is provided at one side of the chemical solution atomizer, an atomization release mechanism is provided in the chemical solution atomizer and is in communication with the insect placing box. The atomization release mechanism includes an atomized gas release port formed on the insect placing box, an ultrasonic atomizer arranged below the atomized gas release port, a suction tube, a chemical solution storage chamber connected to an end of the suction tube, and a piston installed on the chemical solution storage chamber. One sidewall surface of the chemical solution atomizer is an operation panel suitable for controlling atomization. An atomization regulating switch is installed on the operation panel.

Abstract: The device and method for manufacturing metal clad plates in way of continuous casting and rolling provided by the present invention, combines the continuous casting, rolling and heat treatment methods used for single material production with the continuous and large-scale production method of composite strip, greatly improves the production efficiency of composite plates. The present invention can be used for producing single-sided or double-sided composite plates with different thickness specifications, wherein the base material or the composited material can be selected in a wide range, including carbon steel, stainless steel, special alloy steel, titanium, copper and the like. The invention realizes the production of composite plates by continuous casting and rolling, and reduces energy consumption and costs.

Abstract: A charging pile is provided, including: a charging unit and at least one air-cooled radiator arranged in a box; the box includes a first box and a second box, a protection level of the first box is higher than a protection level of the second box; the charging unit is arranged in the first box; an independent heat dissipation air duct is provided in the second box so that the charging unit dissipates heat through the heat dissipation air duct; and the charging unit is configured to charge an electrical equipment, thereby avoiding need to design a heat dissipation module for each power conversion module in the charging pile and then perform a secondary design of the heat dissipation air duct on the entire charging pile in the conventional technology, which reduces cost of the charging pile and improves a level of protection of the charging pile.

Abstract: A production apparatus for short-process metal composite plate manufacturing, comprising a metal supply device including an uncoiler (1), pinch roll (2), shot blasting machine (3), welding device (4), welding pinch roll (5), induction heating apparatus (6), metal delivery machine (7), two crystallization cooling rolls (8), secondary cooling leveling roll (9), rolling mill pinch roll (10), rolling mill (11), on-line cooling apparatus (12), straightener (13), and at least one of a dividing shear (14) and a recoiling machine (15). Also disclosed is a production method for short-process metal composite plate manufacturing. The apparatus and method combine continuous casting, rolling, and heat-treating means for single material production with continuous and large-scale production of composite plate strips, and production efficiency of composite plates is sharply improved.

Abstract: The device and method for manufacturing metal clad plates in way of continuous casting and rolling provided by the present invention, combines the continuous casting, rolling and heat treatment methods used for single material production with the continuous and large-scale production method of composite strip, greatly improves the production efficiency of composite plates. The present invention can be used for producing single-sided or double-sided composite plates with different thickness specifications, wherein the base material or the composited material can be selected in a wide range, including carbon steel, stainless steel, special alloy steel, titanium, copper and the like. The invention realizes the production of composite plates by continuous casting and rolling, and reduces energy consumption and costs.

Abstract: The device and method for manufacturing metal clad strip continuously provided by the present invention, combines casting, rolling and heat treatment used for the single material manufacture with the continuous and large-scale manufacture method for the clad strip, greatly improves the productivity of clad strip. The present invention can be used for manufacturing single-sided or double-sided clad strips with different thickness specifications, wherein the base layer material or the clad layer material can be selected in a wide range, including carbon steel, stainless steel, special alloy steel, titanium, copper and the like. In the present application, continuous casting and rolling clad strip is implemented, which decrease the energy consumption and costs.

Abstract: Aside spray method for cooling the steel strip after hot rolling, comprising the following steps: a) providing side spray devices (30, 30?, 30?) behind each of cooling sections after hot rolling (20, 20?, 20?), the side spray devices being staggered along the two sides of an run out roller table (10), each side spray device comprising at least two spray units, each spray unit comprising spray tubes (2, 2?, 2?) and nozzles on the tubes, the spray tubes being in parallel and vertically arranged along running direction of the steel strip, the covering ranges of adjacent nozzles are partially overlapped, and a total spray coverage of nozzles covers the width of the entire run out roller table; side spray water collecting devices (40, 40?, 40?) are provided on the other side of the run out roller table that is opposite to side spray devices, so that side spray water being collected by the water collecting devices; b) controlling the side spray devices in a mode of open-in-pairs, i.e.