Patents by Inventor Qinggeng ZHUANG

Qinggeng ZHUANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaromatic electrophiles and methods of using thereof
    Patent number: 11492340
    Abstract: Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: November 8, 2022
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Christopher Hadad, Christopher Callam, Jeremy Beck, Qinggeng Zhuang, Andrew Franjesevic, Thomas Corrigan, Craig McElroy
  • HETEROAROMATIC ELECTROPHILES AND METHODS OF USING THEREOF
    Publication number: 20220204472
    Abstract: Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided.
    Type: Application
    Filed: March 10, 2022
    Publication date: June 30, 2022
    Inventors: Christopher Hadad, Christopher Callam, Jeremy Beck, Qinggeng Zhuang, Andrew Franjesevic, Thomas Corrigan, Craig McElroy
  • HETEROAROMATIC ELECTROPHILES AND METHODS OF USING THEREOF
    Publication number: 20200010448
    Abstract: Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided.
    Type: Application
    Filed: February 15, 2018
    Publication date: January 9, 2020
    Inventors: Christopher HADAD, Christopher CALLAM, Jeremy BECK, Qinggeng ZHUANG, Andrew FRANJESEVIC, Thomas CORRIGAN, Craig MCELROY