Patents by Inventor Qinghua Xu

Qinghua Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240110095
    Abstract: The present disclosure belongs to the technical field of nanomaterial synthesis, and in particular, to a preparation method for a narrow-linewidth alloy quantum dot. The preparation method provided by the present disclosure includes the following steps: in a protective gas atmosphere, mixing a cadmium source, an organic ligand, and an organic solvent with a first selenium source for a nucleation reaction to obtain an organic solution of a CdSe quantum dot core; and mixing the organic solution of the CdSe quantum dot core, a zinc source and an inorganic anion source for shell coating to obtain the narrow-linewidth alloy quantum dot, where the inorganic anion source includes a second selenium source.
    Type: Application
    Filed: March 30, 2023
    Publication date: April 4, 2024
    Inventors: Qinghua LI, Lingfeng WANG, Xuping LIU, Xiao JIN, Dongyu LI, Deng WANG, Jingke BAI, Bing XU
  • Patent number: 11949681
    Abstract: Methods and systems are provided for improving user authentication and access control by a network file system service in a multi-tenant public cloud environment by receiving a request for a connection to a file system from a file system client (client), sending an identification request for identification authentication of the client to a control system, receiving a response from the control system, establishing the connection to the file system upon determining that the connection to the file system is allowed based on cloud tenant information associated with the client, receiving an attempt to access the file system from the client by a sub-user, authenticating the sub-user based on the cloud tenant information, issuing a security token including a globally unique sub-user identifier of the sub-user, and using the security token to determine access rights of the sub-user to the file system for a subsequent request.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: April 2, 2024
    Assignee: Alibaba Group Holding Limited
    Inventors: Qingda Lu, Junpu Chen, Qinghua Ye, Lei Wang, Zhiyong Lin, Liping Bao, Jiesheng Wu, Li Xu, Xiaohui Pei, Feng Zhang, Leilei Tian
  • Patent number: 11401560
    Abstract: Disclosed are a set of genes for bladder cancer detection and their use. The set of genes includes the following 32 genes: CA9 gene, CDK1 gene, CTSE gene, DMBT1 gene, ERBB2 gene, HOXA13 gene, IGF2 gene, CXCR2 gene, MAGEA3 gene, MDK gene, MMP1 gene, MMP12 gene, RBP2 gene, CCL18 gene, SNAI2 gene, VEGFA gene, MFAP5 gene, SGK2 gene, WFDC2 gene, POSTN gene, NPFFR2 gene, ANXA10 gene, CTAG2 gene, ZDHHC2 gene, KRT20 gene, PPP1R14D gene, FGD3 gene, AHNAK2 gene, SEMA3D gene, ZNF707 gene, LOC100652931 gene, and LINC00565 gene. After clinical validation, the kit provided by the present invention is used to detect bladder cancer with a high accuracy rate and objective interpretation of results. Meanwhile, as a non-invasive detection, the compliance of patients is greatly improved comparing with the existing cystoscopy, which has an important clinical significance for the early detection and postoperative monitoring of bladder cancer.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: August 2, 2022
    Assignee: HANGZHOU CANHELP GENOMICS TECHNOLOGY CO. LTD.
    Inventors: Qinghua Xu, Dingwei Ye, Qifeng Wang, Chengshu Chen, Jinying Chen, Yifeng Sun, Wanli Ren, Hongying Wang, Yiwang Wu, Tao Huo
  • Patent number: 11312999
    Abstract: A set of genes for the molecular classifying of medulloblastoma is disclosed, including the following 24 genes: EPHA7 gene, OTX2 gene, ROBO1 gene, TTR gene, LGR5 gene, IGF2BP3 gene, TBR1 gene, ZFPM2 gene, TRDC gene, TRAC gene, PEX5L gene, NKD1 gene, RALYL gene, GABRA5 gene, GAD1 gene, TNC gene, KCNA1 gene, EOMES gene, MAB21L2 gene, WIF1 gene, DKK2 gene, PDLIM3 gene, IMPG2 gene, and KHDRBS2 gene. In addition, the present invention also discloses the use of the genome in the preparation of a kit and a gene chip for the molecular classifying of medulloblastoma. After validation, the present invention can accurately differentiate medulloblastoma WNT subgroup, SHE subgroup, Group3 subgroup, and Group4 subgroup, and has important clinical significance for the precise treatment of patients due to the objective results, high accuracy, and short experimental period.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 26, 2022
    Assignee: HANGZHOU CANHELP GENOMICS TECHNOLOGY CO. LTD.
    Inventors: Qinghua Xu, Chengshu Chen, Yifeng Sun, Jinying Chen, Qifeng Wang, Kaibin Song
  • Publication number: 20210254179
    Abstract: A set of genes for the molecular classifying of medulloblastoma is disclosed, including the following 24 genes: EPHA7 gene, OTX2 gene, ROBO1 gene, TTR gene, LGR5 gene, IGF2BP3 gene, TBR1 gene, ZFPM2 gene, TRDC gene, TRAC gene, PEX5L gene, NKD1 gene, RALYL gene, GABRA5 gene, GAD1 gene, TNC gene, KCNA1 gene, EOMES gene, MAB21L2 gene, WIF1 gene, DKK2 gene, PDLIM3 gene, IMPG2 gene, and KHDRBS2 gene. In addition, the present invention also discloses the use of the genome in the preparation of a kit and a gene chip for the molecular classifying of medulloblastoma. After validation, the present invention can accurately differentiate medulloblastoma WNT subgroup, SHH subgroup, Group3 subgroup, and Group4 subgroup, and has important clinical significance for the precise treatment of patients due to the objective results, high accuracy, and short experimental period.
    Type: Application
    Filed: September 6, 2019
    Publication date: August 19, 2021
    Applicant: HANGZHOU CANHELP GENOMICS TECHNOLOGY CO. LTD.
    Inventors: Qinghua XU, Chengshu CHEN, Yifeng SUN, Jinying CHEN, Qifeng WANG, Kaibin SONG
  • Publication number: 20210180140
    Abstract: Disclosed are a set of genes for bladder cancer detection and their use. The set of genes includes the following 32 genes: CA9 gene, CDK1 gene, CTSE gene. DMBT1 gene, ERBB2 gene, HOXA13 gene, IGF2 gene, CXCR2 gene, MAGEA3 gene, MDK gene, MMP1 gene, MMP12 gene, RBP2 gene, CCL18 gene, SNAI2 gene, VEGFA gene, MFAP5 gene, SGK2 gene, WFDC2 gene, POSTN gene, NPFFR2 gene, ANXA10 gene, CTAG2 gene, ZDHHC2 gene, KRT20 gene, PPP1R14D gene, FGD3 gene, AHNAK2 gene, SEMA3D gene, ZNF707 gene, LOC100652931 gene, and LINC00565 gene. After clinical validation, the kit provided by the present invention is used to detect bladder cancer with a high accuracy rate and objective interpretation of results. Meanwhile, as a non-invasive detection, the compliance of patients is greatly improved comparing with the existing cystoscopy, which has an important clinical significance for the early detection and postoperative monitoring of bladder cancer.
    Type: Application
    Filed: January 17, 2019
    Publication date: June 17, 2021
    Applicant: HANGZHOU CANHELP GENOMICS TECHNOLOGY CO. LTD.
    Inventors: Qinghua XU, Qifeng WANG, Chengshu CHEN, Jinying CHEN, Yifeng SUN, Wanli REN, Hongying WANG, Yiwang WU, Tao HUO
  • Patent number: 10148874
    Abstract: A system and machine-implemented method of generating panoramic photographs and videos. Panoramic image data in a YUV data format is received in a YUV data format by an integrated circuit. A format of the panoramic image data is detected by the integrated circuit. The format includes resolution, pixel clock, line frequency information, and field frequency information. The panoramic image data is output, by the integrated circuit, to a memory unit. The panoramic image data is processed by the integrated circuit. The integrated circuit retrieves the panoramic image data from the memory unit. The processed panoramic image data is output, by the integrated circuit, to a processing unit. The processing includes at least one of projecting, stitching or distortion correcting.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: December 4, 2018
    Inventors: Scott Zhihao Chen, Weidong Cai, Qinghua Xu, Bozhong Wu, Peng Chen, Hu Luo
  • Patent number: 10072300
    Abstract: A kit for the prognosis of colorectal cancer, which includes reagents related in detecting the expression level of any one or more genes of the following five genes: BST1, as shown in SEQ ID NO:1; MGST1, as shown in SEQ ID NO:2, 3, 4, 5, 6, 7, 8, 9 or 10; HP, as shown in SEQ ID NO:11 or 12; RCAN3, as shown in SEQ ID NO:13, 14, 15, 16, 17, 18, 19, 20, 21 or 22; and SRA1, as shown in SEQ ID NO:23 or 24. The reagents are used to detect the expression level of any one or more of the above five genes in the preparation of a kit for the prognosis of colorectal cancer. The kit can be used to perform precise prognosis for a patient suffering from colorectal cancer, and has good clinical application prospects.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: September 11, 2018
    Assignee: BIOMERIEUX
    Inventors: Xia Meng, Qinghua Xu, Xun Ye, Fang Liu, Fei Wu
  • Patent number: 9771621
    Abstract: The present invention relates to method and kit for performing a colorectal cancer assay. Especially a method including extracting total RNA from a peripheral blood sample obtained from a patient suspected of having or having colorectal cancer; contacting the total RNA, or cDNA or cRNA obtained from the total RNA, with one or more reagents specific for at least one target gene and no more than 100 target genes; and measuring the expression level of the at least one target gene and no more than 100 target genes. The at least one target gene and no more than 100 target genes includes one or more members selected from the group consisting of the KLRB1, KLRC2, KLRC3, KLRD1, KLRK1, CD247, RRAS2, SH2D1B, LCK, MRPS6, SPRY4, CYBB, DUSP2, PDE4D, SH2D2A, GZMB, INSR, ITGAM, VCAN, CD163, P2RY10, CD226, MRPL10, ITPRIPL2, CD2, and NUDT16 genes.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: September 26, 2017
    Assignee: BIOMERIEUX
    Inventors: Xun Ye, Fei Wu, Qinghua Xu, Xia Meng, Bruno Mougin, Fang Liu
  • Patent number: 9689041
    Abstract: The present invention provides a method for determining in vitro, in a peripheral blood sample, the probability for an individual to suffer from a colorectal cancer, using the comparison of the amount of expression products of nucleic acids of genes of the individual to be tested with the amount of expression products of nucleic acids of the same genes obtained from a CRC group of patients constituting the positive control and with the amount of expression products of nucleic acids of the same genes obtained from a CNC group of individuals constituting the negative control; and a kit comprising specific binding partners for said expression products.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: June 27, 2017
    Assignee: BIOMERIEUX
    Inventors: Xun Ye, Fei Wu, Qinghua Xu, Fang Liu, Xia Meng, Bruno Mougin
  • Publication number: 20160319371
    Abstract: The present invention relates to method and kit for performing a colorectal cancer assay. Especially a method including extracting total RNA from a peripheral blood sample obtained from a patient suspected of having or having colorectal cancer; contacting the total RNA, or cDNA or cRNA obtained from the total RNA, with one or more reagents specific for at least one target gene and no more than 100 target genes; and measuring the expression level of the at least one target gene and no more than 100 target genes. The at least one target gene and no more than 100 target genes includes one or more members selected from the group consisting of the KLRB1, KLRC2, KLRC3, KLRD1, KLRK1, CD247, RRAS2, SH2D1B, LCK, MRPS6, SPRY4, CYBB, DUSP2, PDE4D, SH2D2A, GZMB, INSR, ITGAM, VCAN, CD163, P2RY10, CD226, MRPL10, ITPRIPL2, CD2, and NUDT16 genes.
    Type: Application
    Filed: July 18, 2016
    Publication date: November 3, 2016
    Applicant: BIOMERIEUX
    Inventors: Xun YE, Fei WU, Qinghua XU, Xia MENG, Bruno MOUGIN, Fang LIU
  • Publication number: 20160304944
    Abstract: A method and kit for discriminating between breast cancer and benign breast disease by the determination of the expression level of at least one target gene having a nucleic acid sequence selected from the nucleic acid sequences set forth in SEQ ID NOs: 1, 2 or 3, 4 and 5 or 6 to obtain an expression profile for the patient, and the comparison of the expression profile of the patient with expression profiles of target genes from patients previously clinically classified as breast cancer and expression profiles of target genes from patients previously clinically classified as benign breast disease.
    Type: Application
    Filed: June 30, 2016
    Publication date: October 20, 2016
    Applicant: BIOMERIEUX
    Inventors: Xun YE, Fei WU, Qinghua XU, Xia MENG, Bruno MOUGIN
  • Patent number: 9422598
    Abstract: A method and kit for the prognosis of colorectal cancer where the method includes the steps of: a) obtaining a peripheral blood sample and extracting total RNA from the sample, b) contacting the total RNA with at least one reagent specific for at least one NK cell gene and no more than 25 specific reagents for 25 NK cell genes, c) determining the expression level of at least one and at most 25 NK cell genes to obtain an expression profile for the patient, d) analyzing the expression profile with expression profiles previously clinically classified as a good prognosis and as a poor prognosis, wherein if the expression profile is clustered with the poor prognosis profiles, then the patient is determined to have a poor prognosis, and if the expression profile is clustered with the good prognosis profiles, then the patient is determined to have a good prognosis.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: August 23, 2016
    Assignee: BIOMERIEUX
    Inventors: Xun Ye, Fei Wu, Qinghua Xu, Xia Meng, Bruno Mougin, Fang Liu
  • Patent number: 9410188
    Abstract: A method and kit are related to discriminating between breast cancer and benign breast disease by the determination of the expression level of at least one target gene including a nucleic acid sequence selected from the nucleic acid sequences set forth in SEQ ID NOs: 1, 2 or 3, 4 and 5 or 6 to obtain an expression profile for the patient, and the comparison of the expression profile of the patient with expression profiles of target genes from patients previously clinically classified as breast cancer and expression profiles of target genes from patients previously clinically classified as benign breast disease.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: August 9, 2016
    Assignee: BIOMERIEUX
    Inventors: Xun Ye, Fei Wu, Qinghua Xu, Xia Meng, Bruno Mougin
  • Publication number: 20160177399
    Abstract: A kit for the prognosis of colorectal cancer, which includes reagents related in detecting the expression level of any one or more genes of the following five genes: BST1, as shown in SEQ ID NO:1; MGST1, as shown in SEQ ID NO:2, 3, 4, 5, 6, 7, 8, 9 or 10; HP, as shown in SEQ ID NO:11 or 12; RCAN3, as shown in SEQ ID NO:13, 14, 15, 16, 17, 18, 19, 20, 21 or 22; and SRA1, as shown in SEQ ID NO:23 or 24. The reagents are used to detect the expression level of any one or more of the above five genes in the preparation of a kit for the prognosis of colorectal cancer. The kit can be used to perform precise prognosis for a patient suffering from colorectal cancer, and has good clinical application prospects.
    Type: Application
    Filed: May 20, 2014
    Publication date: June 23, 2016
    Inventors: Xia MENG, Qinghua XU, Xun YE, Fang LIU, Fei WU
  • Publication number: 20140057802
    Abstract: The present invention provides a method for determining in vitro, in a peripheral blood sample, the probability for an individual to suffer from a colorectal cancer, using the comparison of the amount of expression products of nucleic acids of genes of the individual to be tested with the amount of expression products of nucleic acids of the same genes obtained from a CRC group of patients constituting the positive control and with the amount of expression products of nucleic acids of the same genes obtained from a CNC group of individuals constituting the negative control; and a kit comprising specific binding partners for said expression products.
    Type: Application
    Filed: March 23, 2012
    Publication date: February 27, 2014
    Applicant: BIOMERIEUX
    Inventors: Xun Ye, Fei Wu, Qinghua Xu, Fang Liu, Xia Meng, Bruno Mougin
  • Publication number: 20130072401
    Abstract: A method and kit for the prognosis of colorectal cancer where the method includes the steps of: a) obtaining a peripheral blood sample and extracting total RNA from the sample, b) contacting the total RNA with at least one reagent specific for at least one NK cell gene and no more than 25 specific reagents for 25 NK cell genes, c) determining the expression level of at least one and at most 25 NK cell genes to obtain an expression profile for the patient, d) analyzing the expression profile with expression profiles previously clinically classified as a good prognosis and as a poor prognosis, wherein if the expression profile is clustered with the poor prognosis profiles, then the patient is determined to have a poor prognosis, and if the expression profile is clustered with the good prognosis profiles, then the patient is determined to have a good prognosis.
    Type: Application
    Filed: June 4, 2010
    Publication date: March 21, 2013
    Applicant: BIOMERIEUX
    Inventors: Xun Ye, Fei Wu, Qinghua Xu, Xia Meng, Bruno Mougin, Fang Liu
  • Publication number: 20130072399
    Abstract: A method and kit are related to discriminating between breast cancer and benign breast disease by the determination of the expression level of at least one target gene including a nucleic acid sequence selected from the nucleic acid sequences set forth in SEQ ID NOs: 1, 2 or 3, 4 and 5 or 6 to obtain an expression profile for the patient, and the comparison of the expression profile of the patient with expression profiles of target genes from patients previously clinically classified as breast cancer and expression profiles of target genes from patients previously clinically classified as benign breast disease.
    Type: Application
    Filed: May 28, 2010
    Publication date: March 21, 2013
    Applicant: BIOMERIEUX
    Inventors: Xun Ye, Fei Wu, Qinghua Xu, Xia Meng, Bruno Mougin