Abstract: The present disclosure belongs to the technical field of drug preparation and relates to a perfusate containing nicotinamide (NAM) for intraocular surgery, a method of preparation and use thereof. Provided is use of NAM in perfusates for intraocular surgery. In the present disclosure, the perfusate for intraocular surgery improved with NAM may inhibit corneal endothelial cell damage caused by phacoemulsification, reduce corneal edema caused by phacoemulsification, avoid a significant decrease in the number of corneal endothelial cells (CECs) caused by phacoemulsification, promote recovery of corneal transparency after phacoemulsification, promote recovery of the normal corneal thickness, maintain the normal density and cellular morphology of CECs, and regular expression of functional proteins, and reduce complications caused by phacoemulsification. The present disclosure may provide an effective strategy for realizing the rapid recovery of normal visual function of cataract patients after surgery.

Abstract: The present invention discloses a low-swelling decellularized cornea, its preparation method, and applications. The decellularized cornea is obtained by incorporating methacrylated compounds into a decellularized corneal matrix. The decellularized cornea exhibits thermosensitive and photopolymerizable properties, capable of exuding monomer polymers at temperatures above 25° C. and forming a stable biological adhesion layer on the recipient bed through photopolymerization. The decellularized cornea features abundant material sources and enables rapid trauma repair without surgical sutures.

Abstract: The present invention provides a hot-rolled strip steel and manufacturing method therefor. The hot-rolled strip steel comprises the following components in mass percentage: C: 0.04 to 0.15%, Si?0.50%, Mn: 0.30 to 2.00%, Cr: 1.5 to 4.5%, Cu: 0.10 to 0.60%, P?0.03%, S?0.01%, and Al: 0.01 to 0.60%, with the balance being Fe and unavoidable impurities; and further satisfies: 2.5%?2Mn+Cr?6.0%, with elemental symbols being substituted with mass percentages of corresponding elements in the hot-rolled strip steel for calculation. The hot-rolled strip steel of the present invention exhibits excellent resistance to atmospheric corrosion and mechanical properties, and can be directly used for supporting bracket structural parts such as guardrails, mast towers and photovoltaics without coating on the surface.

Abstract: Disclosed is a stabilization treatment liquid for a 690 MPa-grade weather-resistant bridge steel member. The content in percentage by mass of each component of the stabilization treatment liquid is as follows: the content of ferric trichloride is 3-7%; the content of sodium bisulfite is 1-2%; the content of chromium sulfate is 3-6%; the content of potassium permanganate is 1-4%; the content of polypropylene glycol is 1-2%; the content of sodium carboxymethyl cellulose is 2-5%; and the remainder is deionized water. Also provided is a method for performing stabilization treatment by using the stabilization treatment liquid. According to the present invention, stabilization treatment for a rust layer of a 690 MPa-grade weather-resistant bridge steel member can be achieved, and after treatment, a brown rust layer having uniform color and no rust liquid flow is formed on the surface of the 690 MPa-grade weather-resistant bridge steel member.

Abstract: Use of a recombinant transforming growth factor beta induced (TGFBI) protein in lattice corneal dystrophy (LCD) is provided, belonging to the technical field of biomedicine. Use of a recombinant TGFBI protein and a recombinant TGFBI protein-expressing reagent in preparation of a medicament for treating LCD are provided. It is confirmed that dropping eye drops of the recombinant TGFBI protein can promote the repair of corneal epithelial damages in an LCD mouse model; corneal intrastromal injection of the recombinant TGFBI protein can promote the repair of corneal epithelial damages in the LCD mouse model; and limbal intrastromal injection of an adeno-associated virus (AAV) vector carrying a Tgfbi gene can promote the repair of epithelial damages in a TGFBI point mutation-carrying mouse. Therefore, the recombinant TGFBI protein-related reagents exhibit a potential to treat the LCD.

Abstract: The present disclosure provides a method for building a finite element model of corneal endothelial cells, including: importing a standard corneal model into finite element pre-processing software, and generating 2D meshes, to obtain a basic mesh model; importing a detailed geometric model of corneal endothelial cells; determining a complete corneal endothelial cell model according to the basic mesh model and the detailed geometric model; and performing calculation according to the complete corneal endothelial cell model. The present disclosure can improve the efficiency and effect of building a finite element model of corneal endothelial cells.

Abstract: A preparation method of a double-network versatile hydrogel with antibacterial and drug sequential release capabilities is provided in the present disclosure, belonging to the technical field of biological corneas. The preparation method includes the following steps: mixing filipin protein-methacrylate, glycidyl methacrylate functionalized quaternized chitosan, polydeoxyribonucleotide, and lithium phenyl(2,4,6-trimethylbenzoyl) phosphinate with drug-loaded micelles, followed by cross-linking under irradiation of ultraviolet to construct a double-network versatile hydrogel with antibacterial and drug sequential release capabilities.

Abstract: A method for preparing (S)-nicotine by reduction includes conducting a reduction process on an alkene compound as shown in Formula I and/or an iminium cation compound as shown in Formula II, thereby producing (S)-nicotine. The method is simple, safe, reliable, and yields both high purity and high quantities of (S)-nicotine production.

Abstract: A transparent sclera-based corneal repair material, and a preparation method and use thereof, belonging to the technical field of medical repair materials are disclosed. The sclera, a natural biological material that is convenient to obtain, is used as a source of the corneal repair material. The opaque sclera is hyalinized by compressing. Carboxyl groups on a scleral fibrin are activated by cross-linking, such that amino groups of the sclera combine with the carboxyl groups to form an amide bond. The amide bond belongs to a covalent bond and has a desirable stability, thereby maintaining a transparency of the sclera after the compressing. Therefore, the transparent sclera can be used as a transparent corneal tissue repair material.

Abstract: A preparation method of a double-network versatile hydrogel with antibacterial and drug sequential release capabilities is provided in the present disclosure, belonging to the technical field of biological corneas. The preparation method includes the following steps: mixing filipin protein-methacrylate, glycidyl methacrylate functionalized quaternized chitosan, polydeoxyribonucleotide, and lithium phenyl(2,4,6-trimethylbenzoyl) phosphinate with drug-loaded micelles, followed by cross-linking under irradiation of ultraviolet to construct a double-network versatile hydrogel with antibacterial and drug sequential release capabilities.

Abstract: The present disclosure provides a method for building a finite element model of corneal endothelial cells, including: importing a standard corneal model into finite element pre-processing software, and generating 2D meshes, to obtain a basic mesh model; importing a detailed geometric model of corneal endothelial cells; determining a complete corneal endothelial cell model according to the basic mesh model and the detailed geometric model; and performing calculation according to the complete corneal endothelial cell model. The present disclosure can improve the efficiency and effect of building a finite element model of corneal endothelial cells.

Abstract: The present disclosure discloses a pattern sheet, a semiconductor intermediate product, and a hole etching method. The pattern sheet includes a substrate, a dielectric layer, and a mask structure. The mask structure includes a multi-layer mask layer. An uppermost mask layer is a photoresist layer. A thickness of each layer of the mask layer and etching selectivity ratios between the layers below the mask layer satisfy that in each two neighboring layers of the mask layer, a lower layer of the mask layer is etched to form a through-hole penetrating a thickness of the lower layer of the mask layer, a remaining thickness of the upper layer of the mask layer is greater than or equal to zero.

Abstract: In view of the problem that the current prevention and treatment manners for corneal neovascularization (CNV) may cause complications, the present disclosure provides an application of CB-839 in preparation of a drug for inhibiting CNV. The CB-839-loaded drug of the present disclosure can significantly inhibit CNV in mice and reduce the infiltration of inflammatory cells without obvious side effects, which makes up for the shortcoming of the prior art.

Abstract: A preparation method of a nanozyme composite-based hybrid hydrogel eye drop includes synthesizing a tannin-coordinated silver/cobalt composite nanoparticle through a coordination reaction of cobalt chloride hexahydrate with ammonia water and an oxidation-reduction reaction of silver nitrate with tannin; and mixing the silver/cobalt composite nanoparticle with an acrylate-modified gelatin, conducting an ultrasonic treatment to allow complete dissolution, and irradiating a resulting mixture under ultraviolet (UV) light to obtain the nanozyme composite-based hybrid hydrogel eye drop. The preparation method of the present disclosure has simple operations and a short preparation time. The eye drop prepared by the preparation method shows a broad-spectrum bactericidal effect against a variety of bacteria and fungi, and has prominent preventive and therapeutic effects for bacterial and drug-resistant bacterial corneal infections.

Abstract: In view of the problem that the current prevention and treatment manners for corneal neovascularization (CNV) may cause complications, the present disclosure provides an application of CB-839 in preparation of a drug for inhibiting CNV. The CB-839-loaded drug of the present disclosure can significantly inhibit CNV in mice and reduce the infiltration of inflammatory cells without obvious side effects, which makes up for the shortcoming of the prior art.

Abstract: A preparation method of a nanozyme composite-based hybrid hydrogel eye drop includes synthesizing a tannin-coordinated silver/cobalt composite nanoparticle through a coordination reaction of cobalt chloride hexahydrate with ammonia water and an oxidation-reduction reaction of silver nitrate with tannin; and mixing the silver/cobalt composite nanoparticle with an acrylate-modified gelatin, conducting an ultrasonic treatment to allow complete dissolution, and irradiating a resulting mixture under ultraviolet (UV) light to obtain the nanozyme composite-based hybrid hydrogel eye drop. The preparation method of the present disclosure has simple operations and a short preparation time. The eye drop prepared by the preparation method shows a broad-spectrum bactericidal effect against a variety of bacteria and fungi, and has prominent preventive and therapeutic effects for bacterial and drug-resistant bacterial corneal infections.

Abstract: The present disclosure discloses a pattern sheet, a semiconductor intermediate product, and a hole etching method. The pattern sheet includes a substrate, a dielectric layer, and a mask structure. The mask structure includes a multi-layer mask layer. An uppermost mask layer is a photoresist layer. A thickness of each layer of the mask layer and etching selectivity ratios between the layers below the mask layer satisfy that in each two neighboring layers of the mask layer, a lower layer of the mask layer is etched to form a through-hole penetrating a thickness of the lower layer of the mask layer, a remaining thickness of the upper layer of the mask layer is greater than or equal to zero.

Abstract: Retinal pigment epithelial cells can be used for replacing corneal endothelial cells, preventing and treating diseases or symptoms such as corneal endothelial functional decompensation. The retinal pigment epithelial cell transplantation, e.g., to the anterior chamber of an eye of the subject, can restore corneal transparency, reduce corneal thickness, reconstruct corneal endothelial barrier function, effectively treat corneal endothelial functional decompensation and corneal endothelial dysfunction.

Abstract: A sympathetic activation inhibitor and/or an ?1-adrenergic receptor inhibitor in preparing a medicine for treating dry eyes and belonging to the technical field of medicines for treating dry eyes, and a use of a sympathetic activation inhibitor and/or an ?1-adrenergic receptor inhibitor in preparing a medicine for treating or relieving dry eye syndrome. The medicine prepared by the use can antagonize an ?1-adrenergic receptor (including an ?1a-adrenergic receptor) or inhibit sympathetic activation, and can relieve and treat dry eye symptoms.

Abstract: The present disclosure provides a methylcobalamin ophthalmic preparation and a preparation method and use thereof, belonging to the technical field of eye drops. The methylcobalamin ophthalmic preparation includes a methylcobalamin technical (TC) and proanthocyanidin, where the methylcobalamin TC and the proanthocyanidin have a mass ratio of (0.02-0.1):(0-0.5); and a dosage form of the methylcobalamin ophthalmic preparation is one or more of a drop, a hydrogel, and a liposome. In the present disclosure, the methylcobalamin is used as an active ingredient, and the proanthocyanidin is used as a synergist of the methylcobalamin; the methylcobalamin ophthalmic preparation can promote corneal nerve regeneration, accelerate corneal epithelial healing, and effectively inhibit corneal neovascularization to improve corneal perception.