Patents by Inventor Qingli Bie

Qingli Bie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Wnt Family Member 4/Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta (Wnt4/YWHAZ) Co-Modified Mesenchymal Stem Cell (MSC)-Derived Exosome, and Preparation Method and Use Thereof
    Publication number: 20220387508
    Abstract: The present disclosure provides a Wnt family member 4/tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (Wnt4/YWHAZ) co-modified mesenchymal stem cell (MSC)-derived exosome, and a preparation method and use thereof, belonging to the technical field of skin repair. In the present disclosure, the MSC-derived exosome is modified by overexpressing adenovirus vectors expressing a Wnt4 gene and a YWHAZ gene in the MSCs, such that the exosome overexpresses the Wnt4 gene and the YWHAZ gene, to achieve a medicinal purpose of promoting regeneration and repair of a scalded skin tissue in a rat with the MSC-derived exosome.
    Type: Application
    Filed: May 21, 2020
    Publication date: December 8, 2022
    Inventors: Bin Zhang, Bo Ban, Mei Zhang, Qingli Bie, Sen Wang, Haixin Dong, Jie Wen, Shushan Han, Zhi Chen