Abstract: The invention provides a diagnostic kit for metastasis and invasion of breast cancer and a use of an shRNA molecule for silencing expression of human LINC01614. The shRNAs obtained by the invention can interfere with the expression of LINC01614, thereby reducing the migration and invasion ability of tumor cells, inhibiting the expression of EMT proteins, and inhibiting tumor formation and lung metastasis in an animal model in vivo. The invention provides a new solution for targeted therapy of breast cancer. Therefore, the kit for diagnosing metastasis and invasion of breast cancer and the medication for treating metastasis and invasion of breast cancer are developed. The invention provides a new way and strategy for diagnosing and treating metastasis and invasion of breast cancer.

Abstract: The present disclosure discloses a method for calculating a safe drilling fluid density in a fractured formation, including the following steps: S1, performing image processing to identify a downhole fracture; S2, establishing three-dimensional (3D) geological models based on parameters of the downhole fracture, and establishing a drilling wellbore model based on a size and length of a wellbore; S3, assigning the model with material parameters, boundary conditions, and upper and lower bounds of an initial drilling fluid density, and calculating accuracy; S4, solving the 3D geological models using a 3-dimension distinct element code (3DEC) and determining stability of a well wall; S5, determining upper and lower bounds of a drilling fluid density using dichotomy; S6, repeating steps S4 to S5; and S7, after set accuracy conditions are reached, saving and outputting the safe drilling fluid density.

Abstract: Provided herein are therapeutic methods for the treatment of exacerbations of inflammatory respiratory diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and asthma. In particular, the invention provides methods for patient selection, diagnosis, and treatment. Also provided herein are methods for preparing and analyzing lysophosphatidic acid (LPA) samples.

Abstract: The present disclosure discloses a method for calculating a safe drilling fluid density in a fractured formation, including the following steps: S1, performing image processing to identify a downhole fracture; S2, establishing three-dimensional (3D) geological models based on parameters of the downhole fracture, and establishing a drilling wellbore model based on a size and length of a wellbore; S3, assigning the model with material parameters, boundary conditions, and upper and lower bounds of an initial drilling fluid density, and calculating accuracy; S4, solving the 3D geological models using a 3-dimension distinct element code (3DEC) and determining stability of a well wall; S5, determining upper and lower bounds of a drilling fluid density using dichotomy; S6, repeating steps S4 to S5; and S7, after set accuracy conditions are reached, saving and outputting the safe drilling fluid density.

Abstract: A functional electrical stimulation system having a boost module to raise an output voltage of a primary power to a first preset voltage, an energy storage module, connected to the boost module, configured to store electrical energy of the first preset voltage, a central control unit configured to generate data packets of electrical stimulation parameters, and an electrical stimulation output channel, connected to the energy storage module, configured to receive the data packets of electrical stimulation parameters, analyze the electrical stimulation parameters from the data packets, convert electrical energy stored in the energy storage module to an electrical stimulation pulse corresponding to the electrical stimulation parameters and apply the electrical stimulation pulse to a part of a user.

Abstract: The present invention discloses a functional electrical stimulation system comprising a primary power, a boost module, an energy storage section, an output control relay, an automatic discharge circuit, a foot/hand controlled switch, a current detection chip and a current limiting fuse. The boost module comprises n DC chopper circuits connected in series, and outputs a high voltage of 100-200V. According to an enable signal and a current detection signal, the output control relay disables/enables the DC boost module. The automatic discharge circuit discharges capacitance of the energy storage section automatically when the relay turns off the power input. The Foot/hand controlled switch, the current detection chip and the current limiting fuse form a triple accident protection circuit. The functional electrical stimulation system maximizes the intensity of electrical stimulation within the range that the human body can withstand.

Abstract: A functional electrical stimulation system having a boost module to raise an output voltage of a primary power to a first preset voltage, an energy storage module, connected to the boost module, configured to store electrical energy of the first preset voltage, a central control unit configured to generate data packets of electrical stimulation parameters, and an electrical stimulation output channel, connected to the energy storage module, configured to receive the data packets of electrical stimulation parameters, analyze the electrical stimulation parameters from the data packets, convert electrical energy stored in the energy storage module to an electrical stimulation pulse corresponding to the electrical stimulation parameters and apply the electrical stimulation pulse to a part of a user.

Abstract: The present invention discloses a functional electrical stimulation system comprising a primary power, a boost module, an energy storage section, an output control relay, an automatic discharge circuit, a foot/hand controlled switch, a current detection chip and a current limiting fuse. The boost module comprises n DC chopper circuits connected in series, and outputs a high voltage of 100-200V. According to an enable signal and a current detection signal, the output control relay disables/enables the DC boost module. The automatic discharge circuit discharges capacitance of the energy storage section automatically when the relay turns off the power input. The Foot/hand controlled switch, the current detection chip and the current limiting fuse form a triple accident protection circuit. The functional electrical stimulation system maximizes the intensity of electrical stimulation within the range that the human body can withstand.