Abstract: Disclosed herein is a primer coating composition, which is free of or essentially free of metal effect pigments, including besides water and/or organic solvent(s), a film-forming polymer, optionally a crosslinking agent and further a pigment mixture P-C including in turn at least two kinds of pigments being different from one another, namely at least one organic black or inorganic black pigment P-C1, which is not a carbon black pigment, and which is transparent or substantially transparent to NIR-radiation or which is reflective or substantially reflective to NIR-radiation, and at least one inorganic white pigment P-C2, which is reflective or substantially reflective to NIR-radiation. Further disclosed herein are methods of forming a primer coating film and layer, an at least partially coated substrate, a multilayer coating system and a method for preparing the multilayer coating system.

Abstract: The present application provides modified immune cells that express TLR receptors. In some embodiments, the modified immune cell further comprises an engineered receptor such as a chimeric antigen receptor (CAR). The present application also provides methods and pharmaceutical compositions for cancer treatment using the modified immune cells described herein.

Abstract: Disclosed herein is a multilayer coating including at least one ground coat layer, the at least one ground coat layer including at least one non-platelet-shaped titanium dioxide pigment (T); at least one midcoat layer on top of the at least one ground coat layer, and at least one clearcoat layer on top of the at least one midcoat layer; and having a lightness L* according to CIELab in the viewing angle range from ?15° to +45° of at least 80; in the viewing angle range from +75° to +110° of at least 70, if a metal effect pigment is contained in the midcoat layer; in the viewing angle range from +75° to +110° of at least 75, if no metal effect pigment is contained in the midcoat layer. Further disclosed herein are a method for producing such multilayer coating and a multilayer coated substrate.

Abstract: The present invention relates to Disclosed herein is a multilayer coating system being present on an optionally pre-coated substrate and including at least three coatings layers L1, L2 and L3 being different from one another, the first layer L1 applied on an optionally pre-coated substrate, the second layer L2 applied over L1, and the third top coating layer L3 applied over L2, where layer L1 is formed from a primer coating composition and layer L2 is formed from a basecoat composition different from the primer coating composition, where the primer coating composition is free of or essentially free of metal effect pigments. Further disclosed herein are a method of preparing the multilayer coating system, a kit-of-parts and a method of using the kit-of-parts for improving the LiDAR reflectivity, measured at an angle of incidence of 0°, and the flop index, of multilayer coating systems.

Abstract: Described herein is a polymeric pigment dispersant, a process for preparation of the polymeric pigment dispersant and a pigment dispersion including the pigment dispersant that is used for coating and in printing ink, automotive basecoat, auto-motive clearcoat, mill base, furniture coatings and wood coatings.

Abstract: Disclosed herein is a multilayer coating system present on a substrate and including at least two coating layers L1 and L2 different from one another, namely a first coating layer L1 applied over at least a portion of the substrate, and a second topcoat layer L2 applied over the first coating layer L1, where the topcoat layer L2 is formed from a coating composition including at least one block copolymer containing a backbone and at least two blocks B1 and B2 and side chains S1 and S2 including different polymeric moieties M1 and M2. Also disclosed herein are a method of preparing said multilayer coating system, a coated substrate obtainable therefrom, and a method of using a coating composition including the block copolymer for improving, in particular for increasing, the chromaticity of the multilayer coating system.

Abstract: Disclosed herein is a multilayer coating system present on a substrate and including at least three coating layers L1, L2 and L3 different from one another, namely a first pigmented coating layer L1 applied over at least a portion of the substrate, a second coating layer L2 applied over the first pigmented coating layer L1, and a third coating layer L3 applied over the second coating layer L2, where the second coating layer L2 is formed from a coating composition including at least one block copolymer containing a backbone and at least two blocks B1 and B2 and side chains S1 and S2 including different polymeric moieties M1 and M2. Also disclosed herein are a method of preparing said multilayer coating system, a coated substrate obtainable therefrom, and a method of using a coating composition including the block copolymer for improving the chromaticity of the multilayer coating system.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: Described herein is an aqueous basecoat composition. Also described herein are a method of coating a substrate and use of the aqueous basecoat composition for improving the performance properties of basecoat materials.

Abstract: Described herein is a polymeric pigment dispersant, a process for preparation of the polymeric pigment dispersant and a pigment dispersion including the pigment dispersant that is used for coating and in printing ink, automotive basecoat, auto-motive clearcoat, mill base, furniture coatings and wood coatings.

Abstract: Pigmented masonry compositions are provided that include chemically treated carbon black pigments having attached an organic group including an ionic or an ionizable group, the ionic or ionizable group being present at a level from 1.0 to 3.0 ?mol/m2. The compositions exhibit excellent color consistency and jetness and provide consistent color after long term exposure to high levels of moisture.

Abstract: UV curable coatings containing dual phase filler-polymer compositions with high resistivity, low dielectric constant, good optical density, and controlled electrical resistivity are described, and cured coatings or films formed thereof, along with their use in black matrix, black column spacers, and other light shielding coating elements in LCD. Devices having these black matrices, black column spacers, and/or other light shielding coating elements, and methods of preparing and making these various materials and products are also described.

Abstract: The invention provides composite particles comprising core particles having organosilica particles disposed about the core particles. The invention also provides a process for making the composite particles.

Abstract: UV curable coatings containing dual phase filler-polymer compositions with high resistivity, low dielectric constant, good optical density, and controlled electrical resistivity are described, and cured coatings or films formed thereof, along with their use in black matrix, black column spacers, and other light shielding coating elements in LCD. Devices having these black matrices, black column spacers, and/or other light shielding coating elements, and methods of preparing and making these various materials and products are also described.

Abstract: An aqueous carbon black millbase, an aqueous carbon black liquid coating, and a method of making the millbase and liquid coating are provided. The carbon blacks are modified carbon blacks that are engineered to be able to be stirred into an aqueous vehicle without high energy milling of the carbon black. The modified carbon blacks include low organic treatment levels and the millbase and liquid coating do not require large quantities of dispersant. The resulting coatings exhibit excellent viscosity, color, hiding power and stability.

Abstract: UV curable coatings containing dual phase filler-polymer compositions with high resistivity, low dielectric constant, good optical density, and controlled electrical resistivity are described, and cured coatings or films formed thereof, along with their use in black matrix, black column spacers, and other light shielding coating elements in LCD. Devices having these black matrices, black column spacers, and/or other light shielding coating elements, and methods of preparing and making these various materials and products are also described.

Abstract: CMP processes, tools and slurries utilize composite particles that include core particles having organosilica particles disposed about the core particles. Using these processes, tools and slurries can enhance removal rates, reduce defectivity and increase cleanability with respect to comparable systems and substrates.

Abstract: An aqueoue carbon black millbase, an aqueous carbon black liquid coating, and a method of making the millbase and liquid coating are provided. The carbon blacks are modified carbon blacks that are engineered to be able to be stirred into an aqueous vehicle without high energy milling of the carbon black. The modified carbon blacks include low organic treatment levels and the millbase and liquid coating do not require large quantities of dispersant. The resultant coatings exhibit excellent viscosity, color, hiding power and stability.