Patents by Inventor Qingmin Chen

Qingmin Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20250084435
    Abstract: The present invention relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and/or canine degenerative myelopathy (DM).
    Type: Application
    Filed: July 23, 2024
    Publication date: March 13, 2025
    Inventors: Dinah Wen-Yee SAH, Qingmin CHEN, Joan R. COATES, Holger PATZKE, Jinzhao HOU
  • Compositions and methods for inhibiting expression of transthyretin
    Patent number: 12227744
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: February 18, 2025
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Dinah Wen-Yee Sah, Gregory Hinkle, Rene Alvarez, Stuart Milstein, Qingmin Chen
  • Treatment of amyotrophic lateral sclerosis (ALS)
    Patent number: 12116589
    Abstract: The present invention relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and/or canine degenerative myelopathy (DM).
    Type: Grant
    Filed: August 4, 2022
    Date of Patent: October 15, 2024
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Joan R. Coates, Holger Patzke, Jinzhao Hou
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20240325427
    Abstract: The present disclosure relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and delivery methods for the treatment of spinal cord related disorders including ALS.
    Type: Application
    Filed: January 31, 2024
    Publication date: October 3, 2024
    Inventors: Dinah Wen-Yee SAH, Holger Patzke, Qingmin Chen, Jenna Carroll Soper
  • MICROGLIAL GENE SILENCING USING DOUBLE-STRANDED SIRNA
    Publication number: 20240200063
    Abstract: Microglia are an essential part of the immune system in the central nervous system, as well as potential sources of disease. Gene silencing employs short interfering RNA (siRNA) to selectively target genes that are the source of such diseases. By employing branched siRNA, distribution of the siRNA throughout the CNS, including to the resident microglial cells, may be enhanced as compared to unbranched siRNA. Methods and compositions for the use of branched siRNA in a therapy are contained herein.
    Type: Application
    Filed: March 24, 2022
    Publication date: June 20, 2024
    Inventors: Daniel CURTIS, Aimee JACKSON, Benjamin ANDREONE, Bruno Miguel DA CRUZ GODINHO, Qingmin CHEN
  • Treatment of amyotrophic lateral sclerosis (ALS)
    Patent number: 11931375
    Abstract: The present disclosure relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and delivery methods for the treatment of spinal cord related disorders including ALS.
    Type: Grant
    Filed: March 22, 2022
    Date of Patent: March 19, 2024
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Dinah Wen-Yee Sah, Holger Patzke, Qingmin Chen, Jenna Carroll Soper
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20230323388
    Abstract: The present invention relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and/or canine degenerative myelopathy (DM).
    Type: Application
    Filed: August 4, 2022
    Publication date: October 12, 2023
    Inventors: Dinah Wen-Yee Sah, Qingmin CHEN, Joan R. COATES, Holger PATZKE, Jinzhao HOU
  • COMPOSITIONS AND METHODS OF TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20230295663
    Abstract: The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: February 23, 2023
    Publication date: September 21, 2023
    Inventors: Dinah Wen-Yee SAH, Qingmin CHEN, Jinzhao HOU
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TRANSTHYRETIN
    Publication number: 20230257740
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
    Type: Application
    Filed: April 15, 2022
    Publication date: August 17, 2023
    Inventors: Dinah Wen-yee Sah, Gregory Hinkle, Rene Alvarez, Stuart Milstein, Qingmin Chen
  • Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
    Patent number: 11603542
    Abstract: The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating amyotrophic lateral sclerosis (ALS).
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: March 14, 2023
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Jinzhao Hou
  • AAV VARIANTS WITH ENHANCED TROPISM
    Publication number: 20220281922
    Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 8, 2022
    Inventors: Dinah Wen-Yee SAH, Jinzhao HOU, Kei ADACHI, Wei WANG, Qingmin CHEN, Jenna CARROLL SOPER, Amy REN, Xiao-Qin REN, Benjamin E. DEVERMAN, Viviana GRADINARU, Qin HUANG, Sripriya RAVINDRA KUMAR
  • Treatment of amyotrophic lateral sclerosis (ALS)
    Patent number: 11434502
    Abstract: The present invention relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and/or canine degenerative myelopathy (DM).
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: September 6, 2022
    Assignee: Voyager Therapeutics, Inc.
    Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Holger Patzke, Jinzhao Hou
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20220211744
    Abstract: The present disclosure relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and delivery methods for the treatment of spinal cord related disorders including ALS.
    Type: Application
    Filed: March 22, 2022
    Publication date: July 7, 2022
    Inventors: Dinah Wen-Yee SAH, Holger Patzke, Qingmin Chen, Jenna Carroll Soper
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND DISORDERS ASSOCIATED WITH THE SPINAL CORD
    Publication number: 20220168450
    Abstract: The present disclosure relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and delivery methods for the treatment of spinal cord related disorders including ALS.
    Type: Application
    Filed: April 29, 2020
    Publication date: June 2, 2022
    Inventors: Dinah Wen-Yee SAH, Qingmin CHEN, Jenna CARROLL SOPER, Holger PATZKE, Jinzhao HOU, Carol HUANG, Jeffrey BROWN
  • AAV VARIANTS WITH ENHANCED TROPISM
    Publication number: 20210277418
    Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.
    Type: Application
    Filed: August 2, 2019
    Publication date: September 9, 2021
    Inventors: Dinah Wen-Yee Sah, Jinzhao Hou, Kei Adachi, Wei Wang, Qingmin Chen, Jenna Carroll Soper, Amy Ren, Xiao-Qin Ren, Benjamin E. Deverman, Viviana Gradinaru, Qin Huang
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND DISORDERS ASSOCIATED WITH THE SPINAL CORD
    Publication number: 20210254103
    Abstract: The present disclosure relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and delivery methods for the treatment of spinal cord related disorders including ALS.
    Type: Application
    Filed: July 2, 2019
    Publication date: August 19, 2021
    Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Jenna Carroll Soper, Holger Patzke, Jinzhao Hou, Steven M. Hersch
  • Compositions and Methods for Inhibiting Expression of Transthyretin
    Publication number: 20200283766
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
    Type: Application
    Filed: January 23, 2020
    Publication date: September 10, 2020
    Inventors: Dinah Wen-Yee Sah, Gregory Hinkle, Rene Alvarez, Stuart Milstein, Qingmin Chen
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20200239912
    Abstract: The present invention relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and/or canine degenerative myelopathy (DM).
    Type: Application
    Filed: October 16, 2018
    Publication date: July 30, 2020
    Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Joan R. Coates, Holger Patzke, Jinzhao Hou
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20200237799
    Abstract: The present disclosure relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and delivery methods for the treatment of spinal cord related disorders including ALS.
    Type: Application
    Filed: October 16, 2018
    Publication date: July 30, 2020
    Inventors: Dinah Wen-Yee Sah, Holger Patzke, Qingmin Chen, Jenna Carroll Soper
  • COMPOSITIONS AND METHODS OF TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20200123574
    Abstract: The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: May 4, 2018
    Publication date: April 23, 2020
    Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Jinzhao Hou