Abstract: A wrist pin and method of reducing wear between members thereof, a piston, a connecting rod, and methods of construction thereof are provided. The wrist pin has a first portion extending between opposite ends configured for receipt in piston pin bores and a second portion extending between opposite ends configured for receipt in the pin bores. The second portion is configured for relative movement with the first portion. The piston includes a piston body having axially aligned pin bores, wherein at least one of the pin bores has a feature to prevent relative rotation of a wrist pin member. The connecting rod includes a connecting rod body having small end bore. The small end bore has a contour to allow relative rotation of a first wrist pin member therein and a feature to prevent relative rotation of a second wrist pin member therein.

Abstract: A wrist pin and method of reducing wear between members thereof, a piston, a connecting rod, and methods of construction thereof are provided. The wrist pin has a first portion extending between opposite ends configured for receipt in piston pin bores and a second portion extending between opposite ends configured for receipt in the pin bores. The second portion is configured for relative movement with the first portion. The piston includes a piston body having axially aligned pin bores, wherein at least one of the pin bores has a feature to prevent relative rotation of a wrist pin member. The connecting rod includes a connecting rod body having small end bore. The small end bore has a contour to allow relative rotation of a first wrist pin member therein and a feature to prevent relative rotation of a second wrist pin member therein.

Abstract: A wrist pin and method of reducing wear between members thereof, a piston, a connecting rod, and methods of construction thereof are provided. The wrist pin has a first portion extending between opposite ends configured for receipt in piston pin bores and a second portion extending between opposite ends configured for receipt in the pin bores. The second portion is configured for relative movement with the first portion. The piston includes a piston body having axially aligned pin bores, wherein at least one of the pin bores has a feature to prevent relative rotation of a wrist pin member. The connecting rod includes a connecting rod body having small end bore. The small end bore has a contour to allow relative rotation of a first wrist pin member therein and a feature to prevent relative rotation of a second wrist pin member therein.

Abstract: A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

Abstract: The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.

Abstract: A wrist pin and method of reducing wear between members thereof, a piston, a connecting rod, and methods of construction thereof are provided. The wrist pin has a first portion extending between opposite ends configured for receipt in piston pin bores and a second portion extending between opposite ends configured for receipt in the pin bores. The second portion is configured for relative movement with the first portion. The piston includes a piston body having axially aligned pin bores, wherein at least one of the pin bores has a feature to prevent relative rotation of a wrist pin member. The connecting rod includes a connecting rod body having small end bore. The small end bore has a contour to allow relative rotation of a first wrist pin member therein and a feature to prevent relative rotation of a second wrist pin member therein.

Abstract: A wrist pin and method of reducing wear between members thereof, a piston, a connecting rod, and methods of construction thereof are provided. The wrist pin has a first portion extending between opposite ends configured for receipt in piston pin bores and a second portion extending between opposite ends configured for receipt in the pin bores. The second portion is configured for relative movement with the first portion. The piston includes a piston body having axially aligned pin bores, wherein at least one of the pin bores has a feature to prevent relative rotation of a wrist pin member. The connecting rod includes a connecting rod body having small end bore. The small end bore has a contour to allow relative rotation of a first wrist pin member therein and a feature to prevent relative rotation of a second wrist pin member therein.

Abstract: A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

Abstract: A piston assembly and method of assembly thereof, a wrist pin, a piston, a connecting rod, and methods of construction thereof is provided. The assembly includes a piston body having a pair laterally spaced pin bosses with a feature to prevent relative rotation of a first wrist pin member. The assembly has a connecting rod with a small end bore extending along a central axis and allowing relative rotation of the first wrist pin member and a feature with the small end bore to prevent relative rotation of a second wrist pin member. The first and second wrist pin members are moveable relative to one another, wherein the first and second members extend substantially parallel to the central axis through the small end bore.

Abstract: The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.

Abstract: A piston assembly and method of assembly thereof, a wrist pin, a piston, a connecting rod, and methods of construction thereof is provided. The assembly includes a piston body having a pair laterally spaced pin bosses with a feature to prevent relative rotation of a first wrist pin member. The assembly has a connecting rod with a small end bore extending along a central axis and allowing relative rotation of the first wrist pin member and a feature with the small end bore to prevent relative rotation of a second wrist pin member. The first and second wrist pin members are moveable relative to one another, wherein the first and second members extend substantially parallel to the central axis through the small end bore.

Abstract: A crank shaft thrust bearing half includes a semi-cylindrical bearing shell carrying a pair of radially outwardly projecting thrust flanges having outer thrust surfaces. Radial grooves are formed in the thrust face to divide the surface into thrust pads. Each thrust pad has hydrodynamic contours which provide a hydrodynamic wedging action during rotation of the shaft to support high thrust loads. The thrust pad at the trailing end of the flange has an elevated land area spaced about 30° away from the trailing end and includes a long relief area from the land to the end to provide a no contact zone of the flange. Locating the land away from the trailing end and providing the relief zone shifts the peak pressure location away from the end and toward the middle of the bearing to relieve the trailing end from stress. Having radially oriented oil grooves with suitable width enables adequate oil supply and improved hydrodynamic oil film generating capability.

Abstract: A crank shaft thrust bearing half includes a semi-cylindrical bearing shell carrying a pair of radially outwardly projecting thrust flanges having outer thrust surfaces. Radial grooves are formed in the thrust face to divide the surface into thrust pads. Each thrust pad has hydrodynamic contours which provide a hydrodynamic wedging action during rotation of the shaft to support high thrust loads. The thrust pad at the trailing end of the flange has an elevated land area spaced about 30° away from the trailing end and includes a long relief area from the land to the end to provide a no contact zone of the flange. Locating the land away from the trailing end and providing the relief zone shifts the peak pressure location away from the end and toward the middle of the bearing to relieve the trailing end from stress. Having radially oriented oil grooves with suitable width enables adequate oil supply and improved hydrodynamic oil film generating capability.