Abstract: Provided is an isolated antigen-binding protein, wherein the drug is used for the treatment of tumor, and the isolated antigen-binding protein comprises a PD-L1 binding moiety and an OX40 binding moiety, wherein: the OX40 binding moiety is capable of recognizing and/or binding amino acid residues G70 and/or F71 in a human OX40 extracellular domain; and the PD-L1 binding moiety is capable of recognizing and/or binding amino acid residues I54, Y56, E58, Q66 and/or R113 in an N-terminal IgV domain of human PD-L1. Further provided is a use of the isolated antigen-binding protein in preparing a drug, wherein the drug is used for the treatment of tumors.

Abstract: In accordance with various embodiments of the disclosed subject matter, a method and an apparatus for checking and updating data on a client terminal are provided. In some embodiments, the method comprises: obtaining a presentation time interval between two adjacent presenting actions of target data on the client terminal, and obtaining an update time interval between two adjacent updating actions of the target data on a server; calculating a weighted mean value of the target data based on the presentation time interval and the update time interval, as well as a preset presentation weight and a preset update weight; and determining an update check period of the client terminal for periodically performing an update operation to the target data based on the weighted mean value.

Abstract: In accordance with various embodiments of the disclosed subject matter, a method and an apparatus for checking and updating data on a client terminal are provided. In some embodiments, the method comprises: obtaining a presentation time interval between two adjacent presenting actions of target data on the client terminal, and obtaining an update time interval between two adjacent updating actions of the target data on a server; calculating a weighted mean value of the target data based on the presentation time interval and the update time interval, as well as a preset presentation weight and a preset update weight; and determining an update check period of the client terminal for periodically performing an update operation to the target data based on the weighted mean value.