Patents by Inventor Qingqing QI

Qingqing QI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONTINUOUS FLOW SONOGASHIRA COUPLING SYNTHESIS METHOD
    Publication number: 20230183246
    Abstract: The present disclosure relates to a telescoped continuous flow Sonogashira coupling synthesis for some lead compounds to support in vivo studies and pre-clinical evaluation. The application of high throughput tools combined with the telescoped continuous synthesis method can enable an efficient and safe synthesis of compounds of interest involving hazardous coupling reagents such as HATU, while minimizing by-product formation.
    Type: Application
    Filed: May 13, 2021
    Publication date: June 15, 2023
    Applicant: Purdue Research Foundation
    Inventors: David Harley Thompson, Herman O. Sintim, Qingqing Qi, Shruti Biyani
  • Chiral ?-amino tertiary boronic esters
    Patent number: 10738064
    Abstract: The present disclosure relates to a novel, highly efficient and enantiospecific borylation method to synthesize a wide range of enantiopure alfa-amino tertiary boronic esters, and novel alfa-amino tertiary boronic acids and esters prepared by the method. More specifically, highly enantiospecific borylation of configurationally stable ?-N-Boc substituted tertiary organolithium species and HBpin has been developed to synthesize various alfa-amino tertiary boronic esters through the formation of a new C—B bond with excellent enantiopurities.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: August 11, 2020
    Assignee: Purdue Research Foundation
    Inventors: Ei-ichi Negishi, Shiqing Xu, Qingqing Qi, Xuena Yang
  • Novel Chiral Alfa-Amino Tertiary Boronic Esters
    Publication number: 20200079799
    Abstract: The present disclosure relates to a novel, highly efficient and enantiospecific borylation method to synthesize a wide range of enantiopure alfa-amino tertiary boronic esters, and novel alfa-amino tertiary boronic acids and esters prepared by the method. More specifically, highly enantiospecific borylation of configurationally stable ?-N-Boc substituted tertiary organolithium species and HBpin has been developed to synthesize various alfa-amino tertiary boronic esters through the formation of a new C—B bond with excellent enantiopurities.
    Type: Application
    Filed: July 23, 2019
    Publication date: March 12, 2020
    Applicant: Purdue Research Foundation
    Inventors: Ei-ichi Negishi, Shiqing Xu, Qingqing Qi, Xuena Yang
  • [1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof
    Patent number: 9512121
    Abstract: Provided are [1,2,4]triazol[4,3-a]pyridine derivatives as shown in the general formula (I), a preparation method therefor, and a pharmaceutical composition containing the derivative, wherein the pharmaceutical composition is used as a therapeutic agent, and especially used as a c-Met inhibitor and an immunosuppressant. Each substituent in the general formula (I) is the same as that defined in the specification.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: December 6, 2016
    Assignee: Jiangsu Hansoh Pharmaceutical Co., Ltd.
    Inventors: Zhiming Zhao, Haiyang Wang, Chenchen Wu, Qingqing Qi
  • [1,2,4] TRIAZOL [4,3-A] PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF
    Publication number: 20160122339
    Abstract: Provided are [1,2,4]triazol[4,3-a]pyridine derivatives as shown in the general formula (I), a preparation method therefor, and a pharmaceutical composition containing the derivative, wherein the pharmaceutical composition is used as a therapeutic agent, and especially used as a c-Met inhibitor and an immunosuppressant. Each substituent in the general formula (I) is the same as that defined in the specification.
    Type: Application
    Filed: March 4, 2014
    Publication date: May 5, 2016
    Applicant: Jiangsu Hansoh Pharmaceutical Co., Ltd.
    Inventors: Zhiming ZHAO, Haiyang WANG, Chenchen WU, Qingqing QI