Abstract: Provided is an isolated antigen-binding protein, wherein the drug is used for the treatment of tumor, and the isolated antigen-binding protein comprises a PD-L1 binding moiety and an OX40 binding moiety, wherein: the OX40 binding moiety is capable of recognizing and/or binding amino acid residues G70 and/or F71 in a human OX40 extracellular domain; and the PD-L1 binding moiety is capable of recognizing and/or binding amino acid residues I54, Y56, E58, Q66 and/or R113 in an N-terminal IgV domain of human PD-L1. Further provided is a use of the isolated antigen-binding protein in preparing a drug, wherein the drug is used for the treatment of tumors.

Abstract: The present disclosure relates to an item information push method. The item information push method includes: acquiring a plurality of attribute value sets of a to-be-promoted item according to preset value sets of a plurality of specified attributes; for the each attribute value set, determining an estimated warehouse-out quantity of the to-be-promoted item on a plurality of promotion platforms, according to historical traffic and historical warehouse-out quantities corresponding to a plurality of reference items and the historical traffic corresponding to the to-be-promoted item, on the plurality of promotion platforms; setting attribute values of the plurality of specified attributes of the to-be-promoted item according to the determined estimated warehouse-out quantity corresponding to the each attribute value set and the one set of values in the each attribute value set and sending the set attribute values to the plurality of promotion platforms.

Abstract: A muscle-like actuator comprises a motor with a rotatable drive shaft and a string with a shear thickening fluid (STF) embedded therein. One end of the string is attached to the drive shaft and the other end is connected to a load to form a twisted string actuator (TSA). By controlling the speed and current of the motor, the characteristics of the actuator can be changed. Multiple strings may be located in a flexible soft tube to improve the mechanical properties of the actuator.

Abstract: Systems and methods for displaying and associating context images with zones or devices of a security system or a home automation system are provided. Such systems and methods may include associating each of a plurality of zones or devices of the security system or the home automation system with a respective context image and displaying the respective context image for one of the plurality of zones or devices in response to a user interface of the security system or the home automation system receiving user input.

Abstract: The present application provides a bispecific antibody or an antibody mixture with common light chains and a preparation method therefor. the present application also provides a nucleic acid molecule encoding the antibody or the mixture, a recombinant vector and a recombinant cell comprising the nucleic acid molecule, as well as a detection and quantitation method for the antibody or the mixture.

Abstract: The present invention provides a 2,4,6-trisubstituted s-triazine compound represented by general formula (I) or pharmaceutically acceptable salts, prodrugs or solvates thereof, a preparation method therefor, and use of these compounds in preparing drugs for preventing or treating diseases associated with protein kinase and vimentin dysregulation, and cell vacuolization, and in particular, drugs for treating or preventing cancer growth and metastasis, tissue fibrosis and atherosclerosis.

Abstract: An exhaust pipe assembly includes: an exhaust cavity; an exhaust port (234) and at least two air inlets (115) communicating with the exhaust cavity, the exhaust port (234) being disposed at an end of the exhaust pipe assembly; and a water inlet (114), a first part of a water inlet cavity (111), a second part of a water inlet cavity, a water counterflow cavity, and a water outlet (311) that are provided in the exhaust pipe assembly. The water inlets (114) are provided in the same number as the air inlets (115). The first part of the water inlet cavity (111) communicates with the first water inlet portion (114). The second part of the water inlet cavity communicates with the second water inlet portion (114). The water counterflow cavity communicates with the end of the second part of the water inlet cavity located at the exhaust port (234) of the exhaust pipe assembly. The water outlet (311) is disposed at a second end of the exhaust pipe assembly.

Abstract: An additive manufacturing (AM) system includes a process distortion compensation computing system and an AM peripheral device. The process distortion compensation computing system determines a digital nominal model that represents a physical target object excluding a distortion, and a digital distortion model that represents the physical target object including at least one distortion. The AM peripheral device forms a three-dimensional (3D) physical object based on a digital compensation model. The process distortion compensation computing system also determines a digital skeletal model indicating a predicted change in at least one of the shape and volume of the nominal model, and generates the digital compensation model based on the skeletal model that compensates for the at least one distortion.

Abstract: The present application provides a bispecific antibody or an antibody mixture with common light chains and a preparation method therefor. the present application also provides a nucleic acid molecule encoding the antibody or the mixture, a recombinant vector and a recombinant cell comprising the nucleic acid molecule, as well as a detection and quantitation method for the antibody or the mixture.

Abstract: Exhaust pipe assembly (EPA) includes: exhaust cavity; exhaust port (EP) and at least two air inlets communicating with the exhaust cavity, the EP being disposed at an end of the EPA; and a water inlet, a first part of a water inlet cavity (WIC), a second part of a WIC, a water counterflow cavity (WCC), and a water outlet that are provided in the EPA. The water inlets are provided in the same number as the air inlets. The first part of the WIC communicates with the first water inlet portion (WIP). The second part of the WIC communicates with the second WIP. The WCC communicates with the end of the second part of the WIC located at the EP of the EPA. The water outlet is disposed at a second end of the EPA. The first part of the WIC and the WCC each communicate with the water outlet.

Abstract: The present application provides a bispecific antibody or an antibody mixture with common light chains and a preparation method therefor. the present application also provides a nucleic acid molecule encoding the antibody or the mixture, a recombinant vector and a recombinant cell comprising the nucleic acid molecule, as well as a detection and quantitation method for the antibody or the mixture.

Abstract: The present invention provides a 2,4,6-trisubstituted s-triazine compound represented by general formula (I) or pharmaceutically acceptable salts, prodrugs or solvates thereof, a preparation method therefor, and use of these compounds in preparing drugs for preventing or treating diseases associated with protein kinase and vimentin dysregulation, and cell vacuolization, and in particular, drugs for treating or preventing cancer growth and metastasis, tissue fibrosis and atherosclerosis.

Abstract: An additive manufacturing (AM) system comprising a process distortion compensation computing system configured to determine a digital nominal model that represents a physical target object excluding a distortion, and a digital distortion model that represents the physical target object including at least one distortion. The AM system further comprises an AM peripheral device configured to form a three-dimensional physical object based on a digital compensation model. The process distortion compensation computing system determines a material volume difference between the digital nominal model and the digital distortion model, and generates the digital compensation model that compensates for the material volume difference.

Abstract: An additive manufacturing (AM) system includes a process distortion compensation computing system and an AM peripheral device. The process distortion compensation computing system determines a digital nominal model that represents a physical target object excluding a distortion, and a digital distortion model that represents the physical target object including at least one distortion. The AM peripheral device forms a three-dimensional (3D) physical object based on a digital compensation model. The process distortion compensation computing system also determines a digital skeletal model indicating a predicted change in at least one of the shape and volume of the nominal model, and generates the digital compensation model based on the skeletal model that compensates for the at least one distortion.

Abstract: Systems and methods for displaying and associating context images with zones or devices of a security system or a home automation system are provided. Such systems and methods may include associating each of a plurality of zones or devices of the security system or the home automation system with a respective context image and displaying the respective context image for one of the plurality of zones or devices in response to a user interface of the security system or the home automation system receiving user input.

Abstract: An additive manufacturing (AM) system comprising a process distortion compensation computing system configured to determine a digital nominal model that represents a physical target object excluding a distortion, and a digital distortion model that represents the physical target object including at least one distortion. The AM system further comprises an AM peripheral device configured to form a three-dimensional physical object based on a digital compensation model. The process distortion compensation computing system determines a material volume difference between the digital nominal model and the digital distortion model, and generates the digital compensation model that compensates for the material volume difference.

Abstract: This invention disclosed a method for preparing the ultrafine intermetallic particles reinforced metal matrix composites (MMC). The particle size of ultrafine intermetallic particles is about 0.01˜5 ?m. In this method, intermetallic particles and metal matrix were first ball milled together to get the mixed powder. Then, powders were cold-pressed then vacuum melting with metals to prepare the reinforced metal matrix composites materials. The intermetallic particles addition amount in this is 1˜30 wt %. This invention improve the dispersion properties of intermetallic particles while increase the particle/matrix interface strength. The ultrafine intermetallic particles reinforced MMC shows the very good performance with good ductility and strength.

Abstract: This invention disclosed a method for preparing the ultrafine intermetallic particles reinforced metal matrix composites (MMC). The particle size of ultrafine intermetallic particles is about 0.01˜5 ?m. In this method, intermetallic particles and metal matrix were first ball milled together to get the mixed powder. Then, powders were cold-pressed then vacuum melting with metals to prepare the reinforced metal matrix composites materials. The intermetallic particles addition amount in this is 1˜30 wt %. This invention improve the dispersion properties of intermetallic particles while increase the particle/matrix interface strength. The ultrafine intermetallic particles reinforced MMC shows the very good performance with good ductility and strength.

Abstract: A method of titering adeno-associated virus particles in a sample, said method comprising the steps of contacting target cells with a DNA synthesis inhibitor and an agent that increases the activity of the CMV immediate early promoter; contacting target cells treated as in step (a) with a sample containing adeno-associated virus particles; and determining the number of target cells infected by said adeno-associated virus particles in said sample, wherein said number of target cells infected is directly proportional to the titer of said particles in said sample, thereby determining the titer if said adeno-associated virus particles.

Abstract: Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.