Patents by Inventor Qingru Zhang

Qingru Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12102634
    Abstract: A method of preventing or treating a subject suffering from a flavivirus infection caused by Japanese encephalitis virus, Zika virus, or Dengue virus by administering an effective amount of berbamine of Formula (I) or its analogue to the subject. A method of inhibiting the entry of such a flavivirus, an enterovirus and/or a lentivirus into host cells includes contacting the host cells with an effective amount of berbamine of Formula (I) or its analogue. The invention also provides a method of preventing or treating a subject suffering from a coronavirus, particularly SARS-CoV-2 or MERS-CoV, a method of inhibiting the entry of a coronavirus into host cells, as well as uses of berbamine or its analogue in the preparation of a medicament for preventing or treating a flavivirus infection, enterovirus infection, lentivirus infection or coronavirus infection.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: October 1, 2024
    Assignees: 6J Biotechnology (Hong Kong) Limited, City University of Hong Kong
    Inventors: Jianbo Yue, Lihong Huang, Qingru Zhang
  • Patent number: 11986482
    Abstract: Methods of inhibiting endosomal trafficking of PD-L1, inducing PD-L1 secretion via exosomes, decreasing PD-L1 level at a surface of a cancer or tumor cell, and treating a cancer or tumor through promoting T cell immune response in a subject suffering from a cancer or tumor, includes the step of administering a compound of Formula I to various cells. Also, a composition to treat a cancer or a tumor, includes a compound of Formula I and an anti-PD-1 antibody.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: May 21, 2024
    Assignees: City University of Hong Kong, 6J Biotechnology (Hong Kong) Limited
    Inventors: Jianbo Yue, Qingru Zhang, Zuodong Ye, Wang Peng
  • Publication number: 20220378778
    Abstract: A method of preventing or treating a subject suffering from a flavivirus infection by administering an effective amount of berbamine or its analogue to the subject, berbamine has a structure of Formula (I), wherein the flavivirus infection is caused by Japanese encephalitis virus, Zika virus or Dengue virus. A method of inhibiting the entry of a flavivirus, an enterovirus and/or a lentivirus into host cells, comprising contacting the host cells with an effective amount of berbamine of its analogue, berbamine has a structure of Formula (I), wherein the flavivirus is Japanese encephalitis virus, Zika virus or Dengue virus.
    Type: Application
    Filed: September 4, 2020
    Publication date: December 1, 2022
    Inventors: Jianbo Yue, Lihong Huang, Qingru Zhang
  • Patent number: 11484536
    Abstract: A method of treating metastatic cancer in a subject in need thereof including administering an effective amount of a capping protein Z inhibitor to the subject. A method of inhibiting metastasis of cancer cells including administering an effective amount of a capping protein Z inhibitor.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: November 1, 2022
    Assignees: City University of Hong Kong, 6J Biotechnology Limited
    Inventors: Jianbo Yue, Qingru Zhang, Zuodong Ye, Dawei Wang, Kaiyuan Zhu
  • Publication number: 20220305022
    Abstract: Methods of inhibiting endosomal trafficking of PD-L1, inducing PD-L1 secretion via exosomes, decreasing PD-L1 level at a surface of a cancer or tumor cell, and treating a cancer or tumor through promoting T cell immune response in a subject suffering from a cancer or tumor, includes the step of administering a compound of Formula I to various cells. Also, a composition to treat a cancer or a tumor, includes a compound of Formula I and an anti-PD-1 antibody.
    Type: Application
    Filed: March 21, 2022
    Publication date: September 29, 2022
    Inventors: JIANBO YUE, QINGRU ZHANG, ZUODONG YE, WANG PENG
  • Publication number: 20220023307
    Abstract: A method of treating metastatic cancer in a subject in need thereof including administering an effective amount of a capping protein Z inhibitor to the subject. A method of inhibiting metastasis of cancer cells including administering an effective amount of a capping protein Z inhibitor.
    Type: Application
    Filed: July 24, 2020
    Publication date: January 27, 2022
    Inventors: Jianbo Yue, Qingru Zhang, Zuodong Ye, Dawei Wang, Kaiyuan Zhu