Abstract: Methods of inhibiting endosomal trafficking of PD-L1, inducing PD-L1 secretion via exosomes, decreasing PD-L1 level at a surface of a cancer or tumor cell, and treating a cancer or tumor through promoting T cell immune response in a subject suffering from a cancer or tumor, includes the step of administering a compound of Formula I to various cells. Also, a composition to treat a cancer or a tumor, includes a compound of Formula I and an anti-PD-1 antibody.

Abstract: Disclosed is wristband and wrist wearable device, including: a wristband body portion, one end is connected to one end of a device body of a wrist wearable device, and the other end is a free end; and a memory metal portion, which is arranged on the wristband body portion and has an arc-shaped memory state in a natural state, so that the wristband body portion is naturally maintained in an arc shape. The memory metal portion comprises a strip-shaped memory metal piece including a first metal segment, a second metal segment, and a third metal segment that are sequentially connected, the first metal segment and the third metal segment extend along a length direction of the wristband body portion in parallel, the second metal segment is arranged at the free end of the wristband body portion and is provided with at least one bent portion.

Abstract: Disclosed is a wrist-worn device, including a device body and a wristband. The wristband includes: a band body including two detachable ends; an installation part provided on the band body; and a memory metal wire in a shape of a long strip extending along a length direction of the band body. The band body is provided with a first installation cavity, the installation part is provided with a second installation cavity communicated with the first installation cavity, and the device body is provided in the second installation cavity; the memory metal wire is provided in the first installation cavity and passes through the second installation cavity; the memory metal wire is configured with a memory state of being annular in a natural state; and the device body is provided with a positioning groove extending along the length direction of the band body.

Abstract: Disclosed are a wristband and a wrist-worn device. The wristband includes a band body part and a memory metal wire. The band body part has two end portions separable from each other. The memory metal wire has a strip shape extending along a length direction of the band body part and provided to the band body part. The memory metal wire has a memory state of being ring-shaped in a natural state, so that the band body part naturally maintains a ring shape, and the wristband naturally maintains a wearing state. A first installation cavity is provided inside the band body part, and the memory metal wire is accommodated and installed in the first installation cavity.

Abstract: Disclosed are a wristband and a wrist-worn device. The wristband includes a band body part and a memory metal part provided to the band body part. The band body part has two end portions separable from each other. The memory metal part has a memory state of being ring-shaped in a natural state, so that the band body part naturally maintains a ring shape, and the wristband naturally maintains a wearing state.

Abstract: A method of preventing or treating a subject suffering from a flavivirus infection by administering an effective amount of berbamine or its analogue to the subject, berbamine has a structure of Formula (I), wherein the flavivirus infection is caused by Japanese encephalitis virus, Zika virus or Dengue virus. A method of inhibiting the entry of a flavivirus, an enterovirus and/or a lentivirus into host cells, comprising contacting the host cells with an effective amount of berbamine of its analogue, berbamine has a structure of Formula (I), wherein the flavivirus is Japanese encephalitis virus, Zika virus or Dengue virus.

Abstract: A method of treating metastatic cancer in a subject in need thereof including administering an effective amount of a capping protein Z inhibitor to the subject. A method of inhibiting metastasis of cancer cells including administering an effective amount of a capping protein Z inhibitor.

Abstract: Methods of inhibiting endosomal trafficking of PD-L1, inducing PD-L1 secretion via exosomes, decreasing PD-L1 level at a surface of a cancer or tumor cell, and treating a cancer or tumor through promoting T cell immune response in a subject suffering from a cancer or tumor, includes the step of administering a compound of Formula I to various cells. Also, a composition to treat a cancer or a tumor, includes a compound of Formula I and an anti-PD-1 antibody.

Abstract: A method of treating metastatic cancer in a subject in need thereof including administering an effective amount of a capping protein Z inhibitor to the subject. A method of inhibiting metastasis of cancer cells including administering an effective amount of a capping protein Z inhibitor.