Patents by Inventor Qingshan Huang
Qingshan Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11896946Abstract: A device and method for increasing solid holdup in a reaction crystallizer are disclosed. The device includes a discharge pipe, a clear liquid pipe, a clear liquid tank and a gas collecting pipe. A lower end of the discharge pipe is inserted into the crystallizer below the liquid level, while that of the clear liquid pipe is inserted into the clear liquid tank below the liquid level. By using the gas collecting pipe, the reaction crystallizer and the clear liquid tank are communicated all the time. When feeding, a liquid-solid mixture in the crystallizer automatically enters the discharge pipe and flows upward slowly therein, during which solid particles gradually settle down and automatically fall back into the crystallizer while the clear liquid keeps on flowing upward, enters the clear liquid pipe and thereby flows into the clear liquid tank. The clear liquid tank maintains a constant liquid level via overflowing.Type: GrantFiled: July 7, 2020Date of Patent: February 13, 2024Inventors: Quanhong Zhu, Qingshan Huang, Hang Xiao, Chao Yang
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Patent number: 11738318Abstract: The present invention discloses an external loop slurry reactor, comprising a gas-liquid integrated distributor, a riser, a degassing zone, a solid-liquid separation circulation unit, and a storage tank. When the reactor works, reactants are injected into the riser through the gas-liquid integrated distributor; the slurry mixes and flows upwards to the degassing zone at the top for gas removal, and a large number of bubbles are removed. The slurry with catalyst particles then enters a downcomer and flows downwards. The slurry flows into a first-stage hydrocyclone and a multi-stage hydrocyclone in sequence for solid-liquid separation. The diameter of the first-stage hydrocyclone is larger than that of the multi-stage hydrocyclone. The separated solid particles flow back into the riser to continue to participate in the reaction.Type: GrantFiled: September 24, 2019Date of Patent: August 29, 2023Assignees: QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCESInventors: Qingshan Huang, Aqiang Chen, Shujun Geng, Hang Xiao, Chao Yang
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Patent number: 11738285Abstract: Disclosed is an external circulating slurry reactive crystallizer, including a riser, a degassing zone and a downcomer. A lower end of the riser is communicated with a gas inlet pipe, a liquid inlet pipe and a solid feeding pipe, while an upper end of the riser is communicated with a lower end of the degassing zone. An upper end of the downcomer is integrally fixed to a sidewall of the degassing zone. At least one hydrocyclone is arranged at a lower end of the downcomer. The hydrocyclone is provided with an overflow port at an upper end thereof and an underflow port and a valve at a lower end thereof. The overflow port is communicated with the riser. The crystallizer can simultaneously realize reaction, crystallization and separation for continuous production with low cost, regulating and controlling the particle size distribution and morphology of crystals.Type: GrantFiled: February 18, 2020Date of Patent: August 29, 2023Assignees: QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCESInventors: Qingshan Huang, Aqiang Chen, Hang Xiao, Shujun Geng, Chao Yang
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Publication number: 20230211258Abstract: The disclosure provides a device and method for extracting a clean liquid from a slurry reactor in an environment-friendly and energy-saving manner. The method mainly includes the following steps: S1. siphoning slurry in the slurry reactor into a material collecting pipe, and then spraying the slurry into a settling tank, so that solid particles settle in the settling tank and return to the slurry reactor through a discharging pipe; S2. making supernatant in the settling tank flow upward along a settling pipe, and then flow downward at a pipe intersection into a clear liquid pipe and flow into a clear liquid transition tank; S3. discharging liquid from the clear liquid transition tank in an overflow manner to keep the constant liquid level and a pressure required for siphoning; and S4.Type: ApplicationFiled: August 24, 2020Publication date: July 6, 2023Inventors: Qingshan Huang, Quanhong Zhu, Hang Xiao, Jingcai Cheng, Chao Yang
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Publication number: 20230062956Abstract: The present invention discloses an external loop slurry reactor, comprising a gas-liquid integrated distributor, a riser, a degassing zone, a solid-liquid separation circulation unit, and a storage tank. When the reactor works, reactants are injected into the riser through the gas-liquid integrated distributor; the slurry mixes and flows upwards to the degassing zone at the top for gas removal, and a large number of bubbles are removed. The slurry with catalyst particles then enters a downcomer and flows downwards. The slurry flows into a first-stage hydrocyclone and a multi-stage hydrocyclone in sequence for solid-liquid separation. The diameter of the first-stage hydrocyclone is larger than that of the multi-stage hydrocyclone. The separated solid particles flow back into the riser to continue to participate in the reaction.Type: ApplicationFiled: September 24, 2019Publication date: March 2, 2023Inventors: QINGSHAN HUANG, AQIANG CHEN, SHUJUN GENG, HANG XIAO, CHAO YANG
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Publication number: 20220379236Abstract: Disclosed is an external circulating slurry reactive crystallizer, including a riser, a degassing zone and a downcomer. A lower end of the riser is communicated with a gas inlet pipe, a liquid inlet pipe and a solid feeding pipe, while an upper end of the riser is communicated with a lower end of the degassing zone. An upper end of the downcomer is integrally fixed to a sidewall of the degassing zone. At least one hydrocyclone is arranged at a lower end of the downcomer. The hydrocyclone is provided with an overflow port at an upper end thereof and an underflow port and a valve at a lower end thereof. The overflow port is communicated with the riser. The crystallizer can simultaneously realize reaction, crystallization and separation for continuous production with low cost, regulating and controlling the particle size distribution and morphology of crystals.Type: ApplicationFiled: February 18, 2020Publication date: December 1, 2022Applicants: QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCESInventors: Qingshan HUANG, Aqiang CHEN, Hang XIAO, Shujun GENG, Chao YANG
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Publication number: 20220016594Abstract: A device and method for increasing solid holdup in a reaction crystallizer are disclosed. The device includes a discharge pipe, a clear liquid pipe, a clear liquid tank and a gas collecting pipe. A lower end of the discharge pipe is inserted into the crystallizer below the liquid level, while that of the clear liquid pipe is inserted into the clear liquid tank below the liquid level. By using the gas collecting pipe, the reaction crystallizer and the clear liquid tank are communicated all the time. When feeding, a liquid-solid mixture in the crystallizer automatically enters the discharge pipe and flows upward slowly therein, during which solid particles gradually settle down and automatically fall back into the crystallizer while the clear liquid keeps on flowing upward, enters the clear liquid pipe and thereby flows into the clear liquid tank. The clear liquid tank maintains a constant liquid level via overflowing.Type: ApplicationFiled: July 7, 2020Publication date: January 20, 2022Inventors: Quanhong ZHU, Qingshan HUANG, Hang XIAO, Chao YANG
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Publication number: 20210220796Abstract: A device and method for increasing solid holdup in a reaction crystallizer are disclosed. The device includes a discharge pipe, a clear liquid pipe, a clear liquid tank and a gas collecting pipe. A lower end of the discharge pipe is inserted into the crystallizer below the liquid level, while that of the clear liquid pipe is inserted into the clear liquid tank below the liquid level. By using the gas collecting pipe, the reaction crystallizer and the clear liquid tank are communicated all the time. When feeding, a liquid-solid mixture in the crystallizer automatically enters the discharge pipe and flows upward slowly therein, during which solid particles gradually settle down and automatically fall back into the crystallizer while the clear liquid keeps on flowing upward, enters the clear liquid pipe and thereby flows into the clear liquid tank. The clear liquid tank maintains a constant liquid level via overflowing.Type: ApplicationFiled: July 11, 2020Publication date: July 22, 2021Inventors: Quanhong ZHU, Qingshan HUANG, Hang XIAO, Chao YANG
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Patent number: 10376855Abstract: An internal loop airlift reactor (ILAR) for process intensification integrating reaction and separation includes a riser, a downcomer, a hydrocyclone, internals preventing occurrence of dead zone, a gas guide cone, vent holes, and a gas-liquid integrated distributor. The hydrocyclone is arranged at the bottom of the ILAR downcomer; the gas guide cone and the vent holes in the downcomer prevent the gas from entering the hydrocyclone; after the slurry enters the hydrocyclone, the solid-containing slurry enters the riser again from the hydrocyclone underflow, and the solid-free clean product flows out through the hydrocyclone overflow. The ILAR in the present invention has a simple structure and low cost and requires no special liquid-solid separation device. It can achieve gas-liquid-solid three-phase reaction, interphase mass transfer, and solid-liquid separation simultaneously, and is suitable for a gas-liquid-solid three-phase reaction in which the catalyst is solid particles.Type: GrantFiled: September 19, 2017Date of Patent: August 13, 2019Assignees: QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY, CHINESE ACADEMY OF SCIENCE, INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCEInventors: Qingshan Huang, Tao Yang, Fuhua Jiang, Chao Yang
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Publication number: 20190209991Abstract: An internal loop airlift reactor (ILAR) for process intensification integrating reaction and separation includes a riser, a downcomer, a hydrocyclone, internals preventing occurrence of dead zone, a gas guide cone, vent holes, and a gas-liquid integrated distributor. The hydrocyclone is arranged at the bottom of the ILAR downcomer; the gas guide cone and the vent holes in the downcomer prevent the gas from entering the hydrocyclone; after the slurry enters the hydrocyclone, the solid-containing slurry enters the riser again from the hydrocyclone underflow, and the solid-free clean product flows out through the hydrocyclone overflow. The ILAR in the present invention has a simple structure and low cost and requires no special liquid-solid separation device. It can achieve gas-liquid-solid three-phase reaction, interphase mass transfer, and solid-liquid separation simultaneously, and is suitable for a gas-liquid-solid three-phase reaction in which the catalyst is solid particles.Type: ApplicationFiled: September 19, 2017Publication date: July 11, 2019Applicants: QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCESInventors: Qingshan HUANG, Tao YANG, Fuhua JIANG, Chao YANG
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Publication number: 20190201509Abstract: The present invention describes use of spink6 gene and the encoded protein in the manufacture of an anti-tumor drug. spink6 gene has a nucleotide sequence designated as SEQ ID NO:1, and the protein encoded by spink6 gene has an amino acid sequence designated as SEQ ID NO:2. The protein encoded by spink6 gene and its derivatives can be used as potential drugs for treatment of human diseases caused by dysregulation of the cell cycle control, such as various malignant tumors, cell abnormal proliferation, and the like.Type: ApplicationFiled: April 3, 2018Publication date: July 4, 2019Inventors: Qingshan Huang, Wei Wang, Jinjiang Huang, Hairong Lu, Guodong Li
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Publication number: 20130130990Abstract: The present invention describes use of spink6 gene and the encoded protein in the manufacture of an anti-tumor drug. spink6 gene has a nucleotide sequence designated as SEQ ID NO:1, and the protein encoded by spink6 gene has an amino acid sequence designated as SEQ ID NO:2. The protein encoded by spink6 gene and its derivatives can be used as potential drugs for treatment of human diseases caused by dysregulation of the cell cycle control, such as various malignant tumors, cell abnormal proliferation, and the like.Type: ApplicationFiled: October 12, 2009Publication date: May 23, 2013Applicant: FUDAN UNIVERSITYInventors: Qingshan Huang, Wei Wang, Jinjiang Huang, Hairong Lu, Guodong Li
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Patent number: 8241901Abstract: A method of secretory expression of lysostaphin in Escherichia coli at high level, which comprises constructing a expression vector by cloning a sequence encoding a signal peptide which is suitable for secretory expression in Escherichia coli before part or whole gene sequence which encodes mature lysostaphin, and ligating the cloned sequence with a promoter; and transforming Escherichia coli with the expression vector, culturing and fermenting, and then isolating lysostaphin from the supernatant of the fermentation broth. The advantage of secretory expression is that the expression product can exist in the medium in an active form, and thus does not need the process for renaturation of the inclusion body; it is more easily to purify from the supernatant of the fermentation broth with high rate of recovery; and there is less contamination from the host's proteins.Type: GrantFiled: July 11, 2006Date of Patent: August 14, 2012Assignee: Shanghai Hi-Tech United Bio-Technological Research & Development Co., Ltd.Inventors: Qingshan Huang, Hairong Lu, Wanying Lu
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Patent number: 7629438Abstract: A group of new synthetic antimicrobial peptides are disclosed, which demonstrate stronger bactericidal activity than native antimicrobial peptides. The present synthetic antimicrobial peptides can be produced by solid-phase chemical synthesis or gene expression and be used to prepare the medicines for treating the diseases induced by bacteria, viruses and fungi, as well as the anticancer drugs.Type: GrantFiled: July 1, 2003Date of Patent: December 8, 2009Inventors: Qingshan Huang, Guodong Li
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Publication number: 20090186380Abstract: A method of secretory expression of lysostaphin in Escherichia coli at high level, which comprises constructing a expression vector by cloning a sequence encoding a signal peptide which is suitable for secretory expression in Escherichia coli before part or whole gene sequence which encodes mature lysostaphin, and ligating the cloned sequence with a promoter; and transforming Escherichia coli with the expression vector, culturing and fermenting, and then isolating lysostaphin from the supernatant of the fermentation broth. The advantage of secretory expression is that the expression product can exist in the medium in an active form, and thus does not need the process for renaturation of the inclusion body; it is more easily to purify from the supernatant of the fermentation broth with high rate of recovery; and there is less contamination from the host's proteins.Type: ApplicationFiled: July 11, 2006Publication date: July 23, 2009Applicant: Shanghai Hi-Tech United Bio-Technological Research & Development Co., Ltd.Inventors: Qingshan Huang, Hairong Lu, Wanying Lu
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Publication number: 20080070279Abstract: A group of new synthetic antimicrobial peptides are disclosed, which demonstrate stronger bactericidal activity than native antimicrobial peptides. The present synthetic antimicrobial peptides can be produced by solid-phase chemical synthesis or gene expression and be used to prepare the medicines for treating the diseases induced by bacteria, viruses and fungi, as well as the anticancer drugs.Type: ApplicationFiled: July 1, 2003Publication date: March 20, 2008Inventors: Qingshan Huang, Guodong Li