Abstract: A bispecific antibody binding to BCMA and CD3, and a preparation method therefor and the use thereof. A bispecific antibody, which can bind to BCMA and CD3 simultaneously, has specific targeting effects and can efficiently stimulate directed immune responses. The bispecific antibody retains the biological functions of an anti-CD3 antibody and an anti-BCMA antibody, enables the bispecific antibody molecule to achieve excellent biological functions of simultaneously binding to BCMA and CD3 in a targeted manner, forms a bridge between tumor cells and immune effector cells, effectively activates the immune effector cells and the directed immune responses, significantly enhances the effects of immune cells in killing tumor cells, has a high targeted cell killing efficiency, reduces the ADCC effect to the largest extent, has high safety, and has good application prospects in tumor immunotherapy.

Abstract: Embodiments of the present application disclose a three-dimensional model generating method and apparatus, and an electronic device. The three-dimensional model generating method includes: performing feature extraction on an aerial three-dimensional model and a ground three-dimensional model of a to-be-modeled object respectively to obtain at least three sets of feature vectors; performing registration on the aerial three-dimensional model and the ground three-dimensional model based on the feature vectors, and determining a first transition area of a fused three-dimensional model; reconstructing a triangular patch of the first transition area to obtain a second transition area; and performing texture filling on the second transition area, and determining a target three-dimensional model of the to-be-modeled object.

Abstract: A power transformer fault diagnosis method based on a stacked time series network, includes: collecting gas-in-oil data of a transformer in each substation; performing z-score normalization on the collected data to obtain a normalized matrix; dividing the normalized matrix into a training set and a test set in proportion; constructing a stacked time series network based on Xgboost and a bidirectional gated neural network, and inputting the training set and the test set to perform network training; and normalizing real-time collected data to obtain trainable data to predict a fault and update network parameters. The gas-in-oil data is predicted by using Xgboost and a gated neural network, obtains prediction data of a power transformer from two time series networks by using a meta learner, and obtains a fault diagnosis result of the transformer by using a Softmax layer. The neural network has accurate fault diagnosis performance and stable robustness.

Abstract: The present invention provides a sensing electrode, an electrochemical sensing system using the sensing electrode, methods of preparing and using the sensing electrode and the electrochemical sensing system. The sensing electrode includes a base electrode having a conductive surface, and a coating layer formed on the conductive surface. The coating layer has cavities or holes, each of which can be filled with, bound to, or occupied by, an analyte molecule. A decrease of conductivity of the sensing electrode is correlated to the number of cavities or holes that are filled with, bound to, or occupied by, the molecules of the analyte. The invention exhibits numerous technical merits such as suitability for field application, high sensitivity to analyte such as PFOA or PFAS at 1 ppt level, rapid response within minutes, and superior selectivity against interferences such as PFDA, PFOS, PFOSA, and PFHxA, among others.

Abstract: The present application provides a display panel, a manufacturing method, and an electronic device. The electronic device comprises the display panel. The display panel comprises a light-emitting device layer, an encapsulation layer and a barrier film. First scattering particles are distributed in the encapsulation layer, and the light scattering effect of the first scattering particles on the light-emitting device layer can be employed to improve the viewing angle of the display panel. The barrier film comprises at least two antireflective layers with different refractive indexes to increase the transmittance of the barrier film, thereby improving the light extraction efficiency of the display panel.

Abstract: A method for diagnosing transformer fault based on a deep coupled dense convolutional neural network, includes: obtaining datasets of dissolved gas in oil of a transformer in normal and fault states; expanding the datasets by using an adaptive synthetic oversampling method; performing, in a form of a two-dimensional matrix, feature reconstruction on characteristic gas dissolved in the oil; building a transformer fault diagnosis model based on a deep coupled dense convolutional neural network; and dividing an expanded dataset into a training set and a test set, and taking the two-dimensional matrix as an input of the deep coupled dense convolutional neural network and a set label as an output to train the network to obtain a fault diagnosis model. The present disclosure can resolve a problem that a fault diagnosis accuracy rate of the transformer is low due to insufficient and unbalanced fault samples in the dissolved gas in the oil.

Abstract: A lamp base holder, a lamp, and a method for adjusting an angle of a lamp body are provided. The lamp base holder includes a lamp base neck, a lamp cap, and a fixing pin. The fixing pin penetrates the lamp base neck and the lamp cap. The lamp base neck is provided with a first circuit board and a second circuit board. The first circuit board is provided with a first conductive region. The second circuit board is provided with a second conductive region. A first propping pin is connected to the lamp cap or the fixing pin. One end of the first propping pin is constantly abutted against the first conductive region. A second propping pin is further connected to the lamp cap or the fixing pin. One end of the second propping pin is constantly abutted against the second conductive region.

Abstract: A lamp base holder, a lamp, and a method for adjusting an angle of a lamp body are provided. The lamp base holder includes a lamp base neck, a lamp cap, and a fixing pin. The fixing pin penetrates the lamp base neck and the lamp cap. The lamp base neck is provided with a first circuit board and a second circuit board. The first circuit board is provided with a first conductive region. The second circuit board is provided with a second conductive region. A first propping pin is connected to the lamp cap or the fixing pin. One end of the first propping pin is constantly abutted against the first conductive region. A second propping pin is further connected to the lamp cap or the fixing pin. One end of the second propping pin is constantly abutted against the second conductive region.

Abstract: A process is provided that results in an alkyl haloacrylate that is produced by reaction of a dialkyl or diaryl halomalonate with an aldehyde, preferably formalin or paraformaldehyde, and a base catalyst to produce an intermediate that is not isolated and is heated to produce the alkyl haloacrylate. This synthesis can be one pot, meaning it reacts in the same vessel and/or reaction mixture and does not require isolation of the intermediate, and provides an improved yield. In particular, a process is provided that results in an alkyl 2-fluoroacrylate.

Abstract: Improved processes for the preparation of tubulysin compounds, tubulysin drug linker compounds, and their intermediates are disclosed.

Abstract: The present invention provides a sensing device for detecting an analyte containing a non-metallic element such as F. A working sensor has a 3D array of voids each having a void internal wall. The void internal walls have cavities each having a cavity internal wall made from a material containing the non-metallic element. A binding of the analytes to the cavities induces a detectable variation of the optical property of the 3D array of voids. The invention exhibits numerous technical merits such as high sensitivity, high specificity, fast detection, ease of operation, low power consumption, zero chemical release, and low operation cost, among others.

Abstract: Improved processes for the preparation of tubulysin compounds, tubulysin drug linker compounds, and their intermediates are disclosed.

Abstract: Improved processes for the preparation of tubulysin compounds, tubulysin drug linker compounds, and their intermediates are disclosed.

Abstract: The embodiments of the present disclosure relates a cryopump including a pump housing including a suction port, a cold head located within the pump housing, a shielding element located within the pump housing and covering the cold head, a baffle at the suction port, the baffle including a gas passage with an inlet and an outlet, an orthographic projection of the baffle to the cross section of the pump housing completely covers an orthographic projection of the suction port thereto, the gas passage includes a first portion and a second portion intersecting with each other, the inlet is defined by one end of the first portion, the outlet is defined by one end of the second portion.

Abstract: Disclosed is an intelligent intracranial hematoma removal and drainage system, including: an information input module, an information detection module, an intelligent module and a hematoma removal and drainage module, wherein the information input module is used for collecting preoperative data and transmitting the collected preoperative data to the intelligent module; the information detection module is used for acquiring intracranial data monitored in real time and transmitting the monitored intracranial data to the intelligent module; the intelligent module is used for receiving the data from the information input module and the information detection module, analyzing the received data to make a determination, and converting the determination into an instruction signal and transmitting the same to the hematoma removal and drainage module; and the hematoma removal and drainage module is used for receiving an instruction from the intelligent module to remove and drain intracranial hematomas, and feeding data

Abstract: A bispecific antibody, a preparation method therefor and an application thereof. The bispecific antibody includes a monoclonal antibody unit and a single-chain antibody unit. The single-chain antibody unit includes two complete light chain-heavy chain pairs, and is specifically bound to a surface antigen of a tumor cell. The single-chain antibody unit includes two single-chain antibodies. The single-chain antibody includes a heavy chain variable region and a light chain variable region, and is specifically bound to a surface antigen of an immunocyte. The bispecific antibody can be simultaneously bound to the immunocyte and the tumor cell, can mediate a directed immune response, and can effectively kill the tumor cell.

Abstract: The embodiments of the present disclosure relates a cryopump including a pump housing including a suction port, a cold head located within the pump housing, a shielding element located within the pump housing and covering the cold head, a baffle at the suction port, the baffle including a gas passage with an inlet and an outlet, an orthographic projection of the baffle to the cross section of the pump housing completely covers an orthographic projection of the suction port thereto, the gas passage includes a first portion and a second portion intersecting with each other, the inlet is defined by one end of the first portion, the outlet is defined by one end of the second portion.

Abstract: The present invention provides a sensing device for detecting an analyte containing a non-metallic element such as F. A working sensor has a 3D array of voids each having a void internal wall. The void internal walls have cavities each having a cavity internal wall made from a material containing the non-metallic element. A binding of the analytes to the cavities induces a detectable variation of the optical property of the 3D array of voids. The invention exhibits numerous technical merits such as high sensitivity, high specificity, fast detection, ease of operation, low power consumption, zero chemical release, and low operation cost, among others.