Patents by Inventor Qingya ZHAO

Qingya ZHAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of microcystin in preparation of drug for preventing or treating organ and tissue fibrosis diseases
    Publication number: 20220133840
    Abstract: Use of microcystins having a monocyclic heptapeptide structure in preparation of drugs for preventing or treating organ and tissue fibrosis diseases. Preferably, the microcystins are microcystin-LR with amino acids at positions 2 and 4 of a monocyclic heptapeptide structure thereof being leucine and arginine respectively, or are microcystin-RR with amino acids at positions 2 and 4 thereof being both arginine. Also provided is a method for inhibiting myofibroblast differentiation and collagen synthesis. The method is implemented by inhibiting a TGF-?/Smad signaling pathway by using one or more microcystins.
    Type: Application
    Filed: October 30, 2020
    Publication date: May 5, 2022
    Applicant: Nanjing University
    Inventors: Yaping WANG, Lizhi XU, Jie WANG, Qingya ZHAO
  • Use of Microcystin in Preparation of Drug for Preventing or Treating Organ and Tissue Fibrosis Diseases
    Publication number: 20190275103
    Abstract: Use of microcystins having a monocyclic heptapeptide structure in preparation of drugs for preventing or treating organ and tissue fibrosis diseases. Preferably, the microcystins are microcystin-LR with amino acids at positions 2 and 4 of a monocyclic heptapeptide structure thereof being leucine and arginine respectively, or are microcystin-RR with amino acids at positions 2 and 4 thereof being both arginine. Also provided is a method for inhibiting myofibroblast differentiation and collagen synthesis. The method is implemented by inhibiting a TGF-?/Smad signaling pathway by using one or more microcystins.
    Type: Application
    Filed: August 28, 2017
    Publication date: September 12, 2019
    Applicant: Nanjing University
    Inventors: Yaping WANG, Lizhi XU, Jie WANG, Qingya ZHAO