Patents by Inventor Qingzhi Gao

Qingzhi Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrazole compound, preparation method therefor, pharmaceutical composition and medical use thereof
    Patent number: 11692004
    Abstract: The invention discloses a substituted pyrazole compound of formula (I), preparation method therefor, a pharmaceutical composition and a medical use thereof. The said compound features excellent stability, solubility, and low cytotoxicity, which is significantly beneficial for neurological protection, effectively preventing and treating nerve cell injuries. It is an ideal pharmaceutical compound for preventing or treating stroke, cerebral embolism, stroke sequelae, stroke-related motor dysfunction, mitochondrial encephalomyopathy, and amyotrophic lateral sclerosis.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: July 4, 2023
    Assignee: JIANGSU VANGUARD PHARMACEUTICAL CO., LTD.
    Inventors: Qingzhi Gao, Junhua Yao
  • Quinazoline derivative
    Patent number: 10774079
    Abstract: Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: September 15, 2020
    Assignee: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.
    Inventors: Ying Shi, Qingzhi Gao, Xiaozhuo Chen, Yi Mi, Yaran Zhang, Hanyu Yang, Yujie Chen, Chunlei Liu, Guorui Mi, Yuxiu Ma, Dongmin Shen, Yang Guo, Linjing Fan
  • Benzamide derivative
    Patent number: 10550073
    Abstract: The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R1, Z and Q are as described in the description.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: February 4, 2020
    Assignee: CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.
    Inventors: Ying Shi, Yi Mi, Hanyu Yang, Xuliang Wang, Denghuang Gong, Min Bai, Xiaozhuo Chen, Yujie Chen, Xuejiao Zhang, Yuxiu Ma, Qingzhi Gao
  • QUINAZOLINE DERIVATIVE
    Publication number: 20190367500
    Abstract: Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.
    Type: Application
    Filed: August 8, 2019
    Publication date: December 5, 2019
    Inventors: Ying SHI, Qingzhi GAO, Xiaozhuo CHEN, Yi MI, Yaran ZHANG, Hanyu YANG, Yujie CHEN, Chunlei LIU, Guorui MI, Yuxiu MA, Dongmin SHEN, Yang GUO, Linjing FAN
  • Quinazoline derivative
    Patent number: 10421754
    Abstract: Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: September 24, 2019
    Assignee: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.
    Inventors: Ying Shi, Qingzhi Gao, Xiaozhuo Chen, Yi Mi, Yaran Zhang, Hanyu Yang, Yujie Chen, Chunlei Liu, Guorui Mi, Yuxiu Ma, Dongmin Shen, Yang Guo, Linjing Fan
  • BENZAMIDE DERIVATIVE
    Publication number: 20180312462
    Abstract: The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R1, Z and Q are as described in the description.
    Type: Application
    Filed: September 30, 2016
    Publication date: November 1, 2018
    Inventors: Ying SHI, Yi MI, Hanyu YANG, Xuliang WANG, Denghuang GONG, Min BAI, Xiaozhuo CHEN, Yujie CHEN, Xuejiao ZHANG, Yuxiu MA, Qingzhi GAO
  • Pyrazolo[3,4-c]pyridine derivatives
    Patent number: 9975893
    Abstract: Disclosed are a compound of formula (I), a tautomer, an optical isomer or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the above-mentioned compounds. The above-mentioned compounds have the activity of inhibiting Xa factor positive effect, and can be used for the preparation of a medicament for preventing and/or treating diseases inhibiting Xa factor positive effect in case of low bleeding risk.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: May 22, 2018
    Assignee: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.
    Inventors: Ying Shi, Qingzhi Gao, Yi Mi, Xuliang Wang
  • PYRAZOLO[3,4-C]PYRIDINE DERIVATIVES
    Publication number: 20170291896
    Abstract: Disclosed are a compound of formula (I), a tautomer, an optical isomer or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the above-mentioned compounds. The above-mentioned compounds have the activity of inhibiting Xa factor positive effect, and can be used for the preparation of a medicament for preventing and/or treating diseases inhibiting Xa factor positive effect in case of low bleeding risk.
    Type: Application
    Filed: September 2, 2015
    Publication date: October 12, 2017
    Inventors: Ying SHI, Qingzhi GAO, Yi MI, Xuliang WANG
  • QUINAZOLINE DERIVATIVE
    Publication number: 20170226099
    Abstract: Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.
    Type: Application
    Filed: August 11, 2015
    Publication date: August 10, 2017
    Inventors: Ying SHI, Qingzhi GAO, Xiaozhuo CHEN, Yi MI, Yaran ZHANG, Hanyu YANG, Yujie CHEN, Chunlei LIU, Guorui MI, Yuxiu MA, Dongmin SHEN, Yang GUO, Linjing FAN
  • Creatine phosphate analog prodrugs, compositions and uses thereof
    Patent number: 8202852
    Abstract: Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: June 19, 2012
    Assignee: XenoPort, Inc.
    Inventors: Noa Zerangue, Qingzhi Gao, William J. Dower
  • CREATINE PHOSPHATE ANALOG PRODRUGS, COMPOSITIONS AND USES THEREOF
    Publication number: 20100137255
    Abstract: Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.
    Type: Application
    Filed: February 3, 2010
    Publication date: June 3, 2010
    Applicant: XenoPort, Inc.
    Inventors: Noa Zerangue, Qingzhi Gao, William J. Dower
  • Creatine phosphate analog prodrugs, compositions and uses thereof
    Patent number: 7683043
    Abstract: Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: March 23, 2010
    Assignee: XenoPort, Inc.
    Inventors: Noa Zerangue, Qingzhi Gao, William J. Dower
  • Creatine phosphate analog prodrugs, compositions and uses thereof
    Publication number: 20080051371
    Abstract: Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.
    Type: Application
    Filed: June 6, 2007
    Publication date: February 28, 2008
    Inventors: Noa Zerangue, Qingzhi Gao, William Dower
  • Creatine analog prodrugs, compositions and uses thereof
    Publication number: 20070281995
    Abstract: Membrane permeable prodrugs of creatine analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine analogs or pharmaceutical compositions thereof are disclosed.
    Type: Application
    Filed: June 6, 2007
    Publication date: December 6, 2007
    Inventors: Qingzhi Gao, Noa Zerangue, William J. Dower
  • Creatine analog prodrugs, compositions and uses thereof
    Publication number: 20070281983
    Abstract: Membrane permeable prodrugs of creatine analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine analogs or pharmaceutical compositions thereof are disclosed.
    Type: Application
    Filed: June 6, 2007
    Publication date: December 6, 2007
    Inventors: Qingzhi Gao, Noa Zerangue, William J. Dower
  • Salicyl alcohol creatine phosphate prodrugs, compositions and uses thereof
    Publication number: 20070281910
    Abstract: Membrane permeable prodrugs of creatine phosphate, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate or pharmaceutical compositions thereof are disclosed.
    Type: Application
    Filed: June 6, 2007
    Publication date: December 6, 2007
    Inventors: Noa Zerangue, Qingzhi Gao, William J. Dower
  • Creatine prodrugs, compositions and uses thereof
    Publication number: 20070281996
    Abstract: Membrane permeable prodrugs of creatine, pharmaceutical compositions comprising membrane permeable prodrugs of creatine, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine or pharmaceutical compositions thereof are disclosed.
    Type: Application
    Filed: June 6, 2007
    Publication date: December 6, 2007
    Inventors: Qingzhi Gao, Noa Zerangue, William J. Dower
  • Creatine phosphate prodrugs, compositions and uses thereof
    Publication number: 20070281909
    Abstract: Membrane permeable prodrugs of creatine phosphate, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate or pharmaceutical compositions thereof are disclosed.
    Type: Application
    Filed: June 6, 2007
    Publication date: December 6, 2007
    Inventors: Noa Zerangue, Qingzhi Gao, William J. Dower
  • Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use
    Patent number: 7208611
    Abstract: Platinum containing compounds exhibiting cytostatic activity, methods of synthesizing platinum-containing compounds exhibiting cytostatic activity pharmaceutical compositions comprising platinum containing compounds, and methods of using such compounds and compositions for treating cancer are disclosed.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: April 24, 2007
    Assignee: XenoPort, Inc.
    Inventors: Qingzhi Gao, Mark A. Gallop, Jia-Ning Xiang
  • Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use
    Publication number: 20060205677
    Abstract: Platinum containing compounds exhibiting cytostatic activity, methods of synthesizing platinum-containing compounds exhibiting cytostatic activity pharmaceutical compositions comprising platinum containing compounds, and methods of using such compounds and compositions for treating cancer are disclosed.
    Type: Application
    Filed: February 23, 2006
    Publication date: September 14, 2006
    Inventors: Qingzhi Gao, Mark Gallop, Jia-Ning Xiang