Patents by Inventor Qingzhou Ji

Qingzhou Ji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted histone acetylation
    Patent number: 10570378
    Abstract: The present disclosure provides compositions and methods for acetylating histones at targeted chromosomal locations in a cell. In particular, the disclosure provides a fusion protein comprising a DNA binding domain and at least one histone acetyltransferase (HAT) domain, such that the DNA binding domain targets the fusion protein to a targeted chromosomal location and the HAT domain acetylates histones at the targeted location.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: February 25, 2020
    Assignee: Sigma-Aldrich Co. LLC
    Inventors: Qingzhou Ji, Carol Kreader
  • MODIFICATION OF IMMUNE-RELATED GENOMIC LOCI USING PAIRED CRISPR NICKASE RIBONUCLEOPROTEINS
    Publication number: 20190316102
    Abstract: Paired CRISPR nickase ribonucleoproteins engineered to target immune-related genomic loci and methods of using said ribonucleoproteins to modify the immune-related genomic loci.
    Type: Application
    Filed: April 12, 2019
    Publication date: October 17, 2019
    Applicant: SIGMA-ALDRICH CO. LLC
    Inventors: Qingzhou Ji, Gregory D. Davis, Jacob T. Lamberth
  • SYNTHETIC GUIDE RNA FOR CRISPR/CAS ACTIVATOR SYSTEMS
    Publication number: 20190032053
    Abstract: Compositions comprising synthetic two-part aptamer-containing guide RNAs and methods of using said synthetic two-part aptamer-containing guide RNAs with CRISPR/Cas activator systems.
    Type: Application
    Filed: July 24, 2018
    Publication date: January 31, 2019
    Inventors: Qingzhou Ji, Brian Ward, Andrew Ravanelli
  • CELL CYCLE DEPENDENT GENOME REGULATION AND MODIFICATION
    Publication number: 20160376610
    Abstract: Fusion protein comprising a programmable DNA modification protein and a cell cycle regulated protein, and methods of using the fusion protein to modify chromosomal sequences and/or regulate gene expression in a cell cycle dependent manner.
    Type: Application
    Filed: June 24, 2016
    Publication date: December 29, 2016
    Inventors: Gregory D. Davis, Qingzhou Ji, Carol A. Kreader
  • TARGETED HISTONE ACETYLATION
    Publication number: 20150079657
    Abstract: The present disclosure provides compositions and methods for acetylating histones at targeted chromosomal locations in a cell. In particular, the disclosure provides a fusion protein comprising a DNA binding domain and at least one histone acetyltransferase (HAT) domain, such that the DNA binding domain targets the fusion protein to a targeted chromosomal location and the HAT domain acetylates histones at the targeted location.
    Type: Application
    Filed: February 28, 2013
    Publication date: March 19, 2015
    Applicant: SIGMA-ALDRICH CO. LLC
    Inventors: Qingzhou Ji, Carol Kreader