Abstract: The present invention belongs to the technical field of biomedicine, and specifically relates to an extracellular cyclophilin inhibitor and the use thereof, wherein the structural general formula of the extracellular cyclophilin inhibitor of the present invention is as shown in formula (I). According to the present invention, a group capable of reacting with sulfhydryl of cysteine at a specific site on blood albumin is extracted by means of a side chain of a new cyclosporin derivative, and a drug conjugate is rapidly formed after same enters the body, which can effectively restrict the drug to the extracellular area and form targeted inhibition of extracellular cyclophilin, thereby achieving the aim of treating diseases associated therewith.

Abstract: Disclosed is a sewage pipe network hydraulic model building method based on three-dimensional geographic information. According to the method, physical corresponding relation between each manhole node of the sewage pipe network and surrounding buildings is obtained through the three-dimensional geographic information, the population of the sewage pipe network is estimated as prior information according to the corresponding relation, an optimization algorithm is used to determine the total influent time series of all manhole nodes in a region based on the population proportion, and flow fluctuation coefficient for each manhole node is optimized and calculated, such that the influent time series of each manhole node is determined, and the sewage pipe network hydraulic model is built accurately. The present disclosure further provides a method that uses the population data to replace the pipe length/catchment area data as the prior information for sewage pipe network flow check.

Abstract: The present disclosure relates to a method of synthesizing cyclosporine derivatives. The method includes: providing a precursor fluid of the cyclosporine derivative, an alkaline fluid and a ClCH2OCOCl solution; premixing the precursor fluid and the alkaline fluid to obtain a premixed solution; feeding the premixed solution into a first reaction chamber, reacting to prepare a first reaction liquid; feeding the first reaction liquid into a second reaction chamber, reacting the first reaction liquid with a CO2 fluid to prepare a second reaction liquid; and reacting the second reaction liquid with the ClCH2OCOCl solution.

Abstract: A sewage pipe network real-time simulation method based on water supply Internet of Things data drive. The method involves an offline module and a real-time online module, wherein the offline module integrates a sewage pipe network model and a water supply pipe network hydraulic model, corrects historical water consumption of each node of the water supply pipe network hydraulic model, establishes a correction single-objective optimization model of the sewage pipe network model, and determines a transfer coefficient between the water consumption of each node and an inflow of an inspection well; and the real-time online module realizes the real-time simulation of hydraulic parameters of the sewage pipe network model. The method fills a vacancy in the field of sewage pipe network real-time simulation, and important technical support is provided for the management of sewage pipe network systems, and the method has good value in promotion and practical engineering application.

Abstract: The present application provides a small-molecule inhibitor targeting an EB virus nuclear antigen protein, and/or a pharmaceutical composition containing the same, which can be used for the treatment of a disease caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present application further provides a small-molecule inhibitor targeting an EB virus nuclear antigen protein, and/or a pharmaceutical composition containing the same, which can be used for the treatment of a disease caused by EBV infection in a lytic and/or latent phase.

Abstract: The present invention discloses a node flow optimization distribution method for improving the accuracy of transient hydraulic simulation of a water supply in-series pipeline. The present invention optimizes the flow distribution coefficients of intermediate nodes to minimize the impact thereof on the calculation and analysis of transient flow. Further, the simplified error generated by the node flow distribution can be quantified and evaluated by the control threshold of the simplified errors to achieve effective control of the simplified process. In addition, the simplified operation of the method of the present invention is carried out sequentially from the intermediate node with the smallest simplified error, which effectively overcomes the potential defect of the conventional node flow distribution that leads to a significant reduction in the accuracy of the model, and can ensure the reliability and accuracy of the simplified operation of the same-diameter in-series pipeline.

Abstract: The present disclosure relates to a method of synthesizing cyclosporine derivatives. The method includes: providing a precursor fluid of the cyclosporine derivative, an alkaline fluid and a ClCH2OCOCl solution; premixing the precursor fluid and the alkaline fluid to obtain a premixed solution; feeding the premixed solution into a first reaction chamber, reacting to prepare a first reaction liquid; feeding the first reaction liquid into a second reaction chamber, reacting the first reaction liquid with a CO2 fluid to prepare a second reaction liquid; and reacting the second reaction liquid with the ClCH2OCOCl solution.

Abstract: The present disclosure belongs to the field of municipal engineering and urban water supply network, and provides an efficient method for localizing leaks in a districted metering area (DMA) of water supply pipe networks based on valve operations and online water metering, which is implemented in multiple stages to gradually reduce the leaking area. At each stage, the DMA is firstly decomposed into two sub-areas using an optimized valve operation strategy determined by a minimized objective function, wherein a graph theory-based method is used for the solution. Then the sub-areas containing leaks are identified through online water balance analysis based on smart demand meters, thereby reducing the leaking area. The minimum leaking area is identified with the least number of valve operations. Compared with the traditional methods, the method of the present disclosure can obviously improve the efficiency and accuracy of leak localization and is easy to implement.

Abstract: The present disclosure belongs to the field of municipal engineering and urban water supply network, and provides an efficient method for localizing leaks in a districted metering area (DMA) of water supply pipe networks based on valve operations and online water metering, which is implemented in multiple stages to gradually reduce the leaking area. At each stage, the DMA is firstly decomposed into two sub-areas using an optimized valve operation strategy determined by a minimized objective function, wherein a graph theory-based method is used for the solution. Then the sub-areas containing leaks are identified through online water balance analysis based on smart demand meters, thereby reducing the leaking area. The minimum leaking area is identified with the least number of valve operations. Compared with the traditional methods, the method of the present disclosure can obviously improve the efficiency and accuracy of leak localization and is easy to implement.

Abstract: The present invention discloses a node flow optimization distribution method for improving the accuracy of transient hydraulic simulation of a water supply in-series pipeline. The present invention optimizes the flow distribution coefficients of intermediate nodes to minimize the impact thereof on the calculation and analysis of transient flow. Further, the simplified error generated by the node flow distribution can be quantified and evaluated by the control threshold of the simplified errors to achieve effective control of the simplified process. In addition, the simplified operation of the method of the present invention is carried out sequentially from the intermediate node with the smallest simplified error, which effectively overcomes the potential defect of the conventional node flow distribution that leads to a significant reduction in the accuracy of the model, and can ensure the reliability and accuracy of the simplified operation of the same-diameter in-series pipeline.

Abstract: A method for stabilizing an alpha helix of a polypeptide includes steps of: (1) connecting an unnatural amino acid to an amino terminus of the polypeptide and end-capping via an acetylation; (2) processing a product of the step (1) with a thiolene reaction and obtaining a polypeptide compound having a modification of thioether side chains; (3) oxidizing the polypeptide compound having the modification of the thioether side chains, and obtaining a polypeptide compound having a modification of R-configured sulfoxide side chains or S-configured sulfoxide side chains; (4) separating and purifying a product of the step (3), and obtaining the modification of the R-configured sulfoxide side chains. CD diagrams show that, via chiral sulfoxide side chains, the method has good performance on stabilizing the alpha helix of the polypeptide and good tolerance to a polypeptide sequence.