Abstract: The present invention provides a tricyclic compound, its preparation method and medical use. The tricyclic compound is a compound having the structure of the following formula (I), and its pharmaceutically acceptable salt, prodrug, tautomer, stereoisomers or mixtures of stereoisomers. The compound of the present invention has significant activity of antagonizing histamine H1 receptor, and has lower anti-M-choline side effects and lower hERG toxicity, Wherein the group is defined as described in the specification.

Abstract: A protection device for an oil-smoke sensor has a protection housing having two ends and an inner chamber; the first end having a first opening for receiving a probe of the oil-smoke sensor and in communication with the inner chamber; a second opening is disposed on the second end which is opposite to the first opening and in communication with the inner chamber. Because the probe is sealing mounted in the first opening, the probe will not be directly exposed in oil-smoke flow. The protective device is mounted such that the axial direction of the protective device is vertical to the oil-smoke flow direction. Therefore, the inner chamber of the protection housing has a pressure with respect to the oil-smoke flow that tangentially flows at a high speed, and the oil-smoke can only be diffused into the protection housing, thus, the probe is much less likely to be contaminated.

Abstract: The disclosure relates to the field of pharmaceutical technology, in particular, to a compound pharmaceutical composition for treating skin inflammatory diseases, which is characterized in that an active ingredient of the compound pharmaceutical of the disclosure is composed of tofacitinib and crisaborole, and the composition has a stronger therapeutic effect and a lower dosage with a significant synergistic therapeutic effect. The pharmaceutical composition of the disclosure can be used to treat skin inflammatory diseases.

Abstract: The disclosure relates to the field of medicinal chemistry, in particular, to a class of small molecule compounds for inhibiting phosphodiesterase 4 (I), a preparation method thereof and a pharmaceutical composition comprising the compound. The pharmacodynamic test proves that the compound of the disclosure has the inhibitory activity of PDE-4 enzyme and the efficacy of inflammation treatment.

Abstract: The disclosure relates to the field of medicinal chemistry, in particular, to a class of small molecule compounds for inhibiting phosphodiesterase 4 (I), a preparation method thereof and a pharmaceutical composition comprising the compound. The pharmacodynamic test proves that the compound of the disclosure has the inhibitory activity of PDE-4 enzyme and the efficacy of inflammation treatment.

Abstract: A protection device for an oil-smoke sensor has a protection housing having two ends and an inner chamber; the first end having a first opening for receiving a probe of the oil-smoke sensor and in communication with the inner chamber; a second opening is disposed on the second end which is opposite to the first opening and in communication with the inner chamber. Because the probe is sealing mounted in the first opening, the probe will not be directly exposed in oil-smoke flow. The protective device is mounted such that the axial direction of the protective device is vertical to the oil-smoke flow direction. Therefore, the inner chamber of the protection housing has a pressure with respect to the oil-smoke flow that tangentially flows at a high speed, and the oil-smoke can only be diffused into the protection housing, thus, the probe is much less likely to be contaminated.

Abstract: A protection device for an oil-smoke sensor comprises a protection housing (1) having a first end, a second end, and an inner chamber (2); the first end having a first opening (3) for receiving a probe (5) of the oil-smoke sensor and in communication with the inner chamber (2); a second opening (4) is disposed on the second end which is opposite to the first opening (3) and in communication with the inner chamber (2). Because the probe (5) is sealing mounted in the first opening (3), the probe (5) will not be directly exposed in oil-smoke flow. When in use, the protective device is mounted in a manner that the axial direction of the protective device is vertical to the oil-smoke flow direction.

Abstract: The disclosure relates to the field of pharmaceutical technology, in particular, to a compound pharmaceutical composition for treating skin inflammatory diseases, which is characterized in that an active ingredient of the compound pharmaceutical of the disclosure is composed of tofacitinib and crisaborole, and the composition has a stronger therapeutic effect and a lower dosage with a significant synergistic therapeutic effect. The pharmaceutical composition of the disclosure can be used to treat skin inflammatory diseases.

Abstract: A protection device for an oil-smoke sensor comprises a protection housing (1) having a first end, a second end, and an inner chamber (2); the first end having a first opening (3) for receiving a probe (5) of the oil-smoke sensor and in communication with the inner chamber (2); a second opening (4) is disposed on the second end which is opposite to the first opening (3) and in communication with the inner chamber (2). Because the probe (5) is sealing mounted in the first opening (3), the probe (5) will not be directly exposed in oil-smoke flow. When in use, the protective device is mounted in a manner that the axial direction of the protective device is vertical to the oil-smoke flow direction.