Abstract: Hypoallergenic flavor compositions for human and animal foods are described. A method of managing allergic reactions in an animal comprises providing to the animal a hypoallergenic animal food composition comprising a hypoallergenic flavor composition, wherein the hypoallergenic flavor composition comprises substantially all components having a weight average molecular weight of less than 4,000 daltons. The hypoallergenic flavor composition may comprise an oil or fat-based reaction flavor, a water-based reaction flavor, a hypoallergenic animal digest, or a combination comprising one or more of the foregoing components. Also described are packages comprising hypoallergenic animal foods.