Abstract: The disclosure provides a large object processing system and large object processing method thereof. The large object processing system includes a storage device and a processor. The storage device stores a plurality of large object variable forms, a PV processing module, and a large object processing module. The PV processing module receives a request for processing and further searches for a storage device according to the request to obtain a PV form and a plurality of object values in the PV form. The large object processing module determines whether the plurality of object values include object-referencing character strings. Should the plurality of object values include the object-referencing character strings, the large object processing module obtains corresponding large object data according to the object-referencing character strings. The PV processing module replaces the object-referencing character strings in the PV form with the large object data and organizes the PV form.

Abstract: A data flow management system and a data flow management method are provided. The data flow management system includes a memory and a processor electrically connected to the memory and executing a data flow. The processor executes task nodes in the data flow, generates output data, and determines whether a data state of the output data reaches a target data state to decide whether to acquire a next task node in the data flow. When the processor determines the data state of the output data does not reach the target data state, the processor acquires the next task node and decides to execute the next task node in a data branching mode or a data shunting mode according to a data feature set and a branch identifier. When the processor determines the data state of the output data reaches the target data state, the processor ends the data flow.

Abstract: Transgenic non-human mammals and methods of preparing such mammals are disclosed. Homologous recombination is employed to inactivate genes, particularly genes coding for neuronal intermediate filaments. These animals, whose phenotype is characterized by reduced or eliminated levels of a neuronal intermediate filament, are useful as models for studying aging, injury to the nervous system, and pathogenesis of neurodegenerative diseases. They are also useful for the screening of potential therapeutic agents.