Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: CD22 antibodies, a preparation method therefor, and an application thereof. The CD22 antibodies have a high affinity to CD22 protein Therefore, the CD22 antibodies can be used in the preparation of drugs for the treatment of diseases such as tumors and autoimmune diseases.

Abstract: Some embodiments provide a method of identifying packet latency in a software defined datacenter (SDDC) that includes a network and multiple host computers executing multiple machines. At a first host computer, the method identifies and stores (i) multiple time values associated with several packet processing operations performed on a particular packet sent by a first machine executing on the first host computer, and (ii) a time value associated with packet transmission through the SDDC network from the first host computer to a second host computer that is a destination of the particular packet. The method provides the stored time values to a set of one or more controllers to process to identify multiple latencies experienced by multiple packets processed in the SDDC.

Abstract: This application provides a semiconductor device.

Abstract: Some embodiments provide a method for performing data traffic monitoring. The method processes a packet through a packet processing pipeline that includes multiple stages. At a filtering stage, the method tags the packet with a set of monitoring actions for subsequent stages to perform on the packet based on a determination that the packet matches a particular filter. For each stage of a set of packet processing stages subsequent to the filtering stage, the method (i) executes any monitoring actions specified for the stage to perform on the packet and (ii) sends the packet to a next stage in the packet processing pipeline.

Abstract: Example methods and systems to perform flow cache information update(s) for packet processing are described. In one example, a network element may configure flow cache information specifying a set of actions based on a sequence of stages that is executable during slow-path packet processing. The network element may configure dependency information specifying execution dependence or independence among the set of actions during fast-path packet processing. In response to detecting a configuration change associated with stage(s) from the sequence of stages, the network element may identify first action(s) affected by the configuration change and second action(s) not affected by the configuration change. This way, a granular update may be performed to the flow cache information by updating the at least one first action, but not the at least one second action.

Abstract: A test system for measuring the gas permeation parameters of an ultra-low permeability medium in multi-field and multi-phase coupling conditions, comprising a triaxial permeation chamber, a deformation monitoring apparatus, a temperature sensing control apparatus, a volume/pressure controller, a bias stress loading apparatus, a gas injection apparatus, an outlet buffer container, and an ultra-low permeation flow monitoring apparatus. During the test, first applying temperature and triaxial stress control to a rock-soil mass sample; using the gas injection apparatus to inject high-pressure gas into the rock-soil mass sample; after permeation, the high-pressure gas enters the outlet buffer container and the ultra-low permeation flow monitoring apparatus to acquire the gas permeation flow; and, in the test process, the deformation monitoring apparatus can measure the local absolute deformation of the rock-soil mass sample.

Abstract: Provided are an CD22 nano antibody, and a preparation method therefor and an application thereof. The CD22 nano antibody has high affinity with a CD22 protein, and can be used for preparing drugs for treating tumors, autoimmune diseases, etc.

Abstract: Some embodiments provide a method for performing data traffic monitoring. The method processes a packet through a packet processing pipeline that includes multiple stages. At a filtering stage, the method tags the packet with a set of monitoring actions for subsequent stages to perform on the packet based on a determination that the packet matches a particular filter. For each stage of a set of packet processing stages subsequent to the filtering stage, the method (i) executes any monitoring actions specified for the stage to perform on the packet and (ii) sends the packet to a next stage in the packet processing pipeline.

Abstract: Example methods and systems for state consistency monitoring in a network environment are described. In one example, a computer system may identify association chain(s) that associate (a) first state information associated with one or more first network entities residing on a first plane with (b) second state information associated with one or more second network entities residing on a second plane. Based on the association chain(s), a consistency check may be performed to compare multiple first fields of the first state information with multiple second fields of the second state information. In response to determination that there is a state inconsistency based on the consistency check, a remediation action to address the state inconsistency by generating and sending at least one of the following: a notification to a user, and a remediation request to a particular first network entity residing on the first plane or a particular second network entity residing on the second plane.

Abstract: Controlling voltage supplied to a load includes predicting a load current transient, generating a turbo signal in response to predicting the load current transient, and increasing, in response to the turbo signal, responsiveness of a voltage regulator supplying voltage to the load.

Abstract: A high-efficiency cultivation method for high-frequency drip irrigation, water saving, seedling survival and strengthening, and yield increase of cotton fields in saline-alkali soil is provided, belonging to the field of agricultural planting technologies. It mainly includes performing land preparation; setting a planting mode; laying tubes; performing a high frequency drip irrigation; fertilizing with water; performing intertillage; performing chemical control; and performing green prevention and control. The method effectively solves many defects in the existing methods, improves the quality of cotton field preparation and seeding in saline-alkali soil, saves irrigation water, increases the emergence rate and seedling survival rate, improves the saline-alkali resistance of cotton seedlings, increases the yield, and achieves the goal of water-saving, high-quality and high-efficiency cultivation of cotton seedlings in saline-alkali soil.

Abstract: Provided are compositions and methods for use in selectively killing certain types of bacteria which include: C. perfringens, C. sordelli and C. histolyticum. The compositions include lysin PlyCP025, as well as catalytically active fragments thereof, and variants thereof that retain killing activity. Methods for reducing one or more of C. perfringens, C. sordelli or C. histolyticum bacteria are provide and involve contacting such bacteria with a composition that contains PlyCP025 or an enzymatically active fragment or variant thereof, which can be provided as recombinant polypeptides. The composition and methods are useful for human and veterinary purposes. In certain examples, the compositions and methods are used to treat bacteria that infect avian animals. Pharmaceutical formulations containing the polypeptides are provided, as are methods of making the polypeptides using expression vectors. The expression vectors, and cells containing them are included.

Abstract: Some embodiments provide a method for performing data traffic monitoring. For each packet processing stage of a set of packet processing stages in a packet processing pipeline, the method determines whether a packet received by the packet processing pipeline specifies a set of monitoring actions to be performed on the packet. When the packet specifies a set of monitoring action, the method determines whether the monitoring actions in the set are supported by the packet processing stage. The method executes the supported monitoring actions on the packet in addition to processing the packet according to configuration data for the stage.

Abstract: Example methods and systems are provided for cross-cloud connectivity checks. One example method may include detecting a first connectivity check packet that is addressed from a first virtualized computing instance deployed in a first cloud environment; and determining that the first connectivity check packet is destined for a second virtualized computing instance in a second cloud environment reachable via the network device. The method may also comprise: generating a second connectivity check packet by modifying the first connectivity check packet to include one or more indicators that a connectivity check is required along a datapath towards the second virtualized computing instance in the second cloud environment. The method may further comprise: sending the second connectivity check packet to cause one or more observation points along the datapath to, based on the one or more indicators, generate and send report information associated with the second connectivity packet.

Abstract: Provided herein, inter alia, are compositions comprising one or more biologically pure strains of bacteria as well as methods of making and using the same to treat and/or prevent one or more obesity related disorders in a subject m need thereof.

Abstract: Some embodiments provide a method of aggregating and providing packet metrics collected during a live packet monitoring session performed for packets matching a specified set of characteristics. The method receives, from one or more computing devices that process packets during the live packet monitoring session, multiple metrics associated with a set of packets matching the specified set of characteristics. Metrics associated with each packet in the set are accompanied by a packet identifier (ID) used to tag the packet by an initial computing device that processed the packet. The method uses the accompanying packet IDs to aggregate the received plurality of metrics. The method provides (i) an aggregated set of session metrics for the set of packets matching the specified set of characteristics during the live packet monitoring session and (ii) individual packet metrics using the packet IDs for at least one packet in the set of packets.

Abstract: An administrator agent and local worker agents are provided in nodes of a distributed system to support dynamic tracing of runtime data. Trace profiles are associated with the nodes on which the local worker agents reside. The local worker agents monitor the runtime data for an error, and the administrator agent adjusts the trace profile(s) in response to the error(s). The administrator agent sends the adjusted trace profile(s) to the local worker agents, so as to enable trace output data of traces performed by the nodes to be increased or decreased.

Abstract: Example methods and systems are provided for simulation-based cross-cloud connectivity checks. One example method may include injecting a connectivity check packet in a first cloud environment, and obtaining first report information associated with a first stage of forwarding the connectivity check packet from one or more first observation points in the first cloud environment. The method may also comprise: based on configuration information associated with one or more second observation points in the second cloud environment, simulating a second stage of forwarding the connectivity check packet towards a second virtualized computing instance via the one or more second observation points. The method may further comprise: generating second report information associated with the simulated second stage to identify a connectivity status between a first virtualized computing instance and the second virtualized computing instance based on the first report information and the second report information.

Abstract: Provided herein, inter alia, are compositions comprising oxygen tolerant strains of Megasphaera elsdenii and methods of making and using the same to promote improvement of one or more metrics in an animal, such as increased bodyweight/carcass gain, increased feed intake, decreased feed conversion ratio (FCR), decreased medical costs, decreased transition period, decrease use of antibiotics, and reduced mortality.