Abstract: The present disclosure relates to Fourier ptychographic microscopy systems and methods. The system includes: a three-color LED array; a microscope, configured to obtain image information with multi-wavelength, and magnify to generate magnified image information; an RGB camera configured to acquire a first color image with a first resolution based on the magnified image information; and a controller, configured to synchronously control the three-color LED array and the RGB camera, in which the three-color LED array is further configured to display a plurality of illumination patterns, the RGB camera is further configured to acquire synchronously a plurality of first color images, and the controller is further configured to restore a single second image with a second resolution according to the plurality of first color images, and the first resolution is less than the second resolution. The present disclosure improves sampling speed.

Abstract: Microscopic imaging system and method with three-dimensional refractive index tomography are provided. The microscopic imaging system includes: an illumination providing module, configured to provide a beam of parallel lights with a modulated intensity; a microscopic sample, arranged at downstream of the illumination providing module, and configured to modulate a phase of the beam of parallel lights, such that emergent lights passing through the microscopic sample carry information of a three-dimensional refractive index field of the microscopic sample; a microscopic imaging module, arranged at downstream of the microscopic sample, and configured to form an image by using the emergent lights; and a controlling module, configured to process the image to reconstruct three-dimensional refractive index information of the microscopic sample.

Abstract: A microscopic tomography device based on light-sheet and single-pixel imaging is provided. The device includes: a light source; a pattern modulator, configured to modulate light from the light source into different illumination patterns; a light modulator, configured to modulate the illumination patterns as patterned light sheets; a detector, configured to detect the light passing through the sample after the sample is illuminated by the patterned light sheets; a focusing lens, configured to focus the light passing through the sample onto the detector; and a reconstruction component, configured to reconstruct an image of the sample at the illuminated depth using the illumination patterns, corresponding measurements and a single-pixel imaging algorithm.

Abstract: A microscopy imaging system is disclosed.

Abstract: The present disclosure provides a genome-wide association study method for imbalanced samples, including: randomly selecting L subsets from the healthy samples; pairing each of the L subsets with the diseased samples to obtain L sample combinations, and determining key genetic loci corresponding to each sample combination; evaluating a score of an importance degree of each sample combination according to times that each key genetic locus is determined in the L sample combinations; for each healthy sample, determining a mean value of scores of an importance degree of sample combinations that the healthy sample is assigned to, and determining the mean value as a confidence score of the healthy sample; and normalizing the confidence score of each healthy sample to obtain a weight of each healthy sample, and performing weighted logistic regression according to the weight of each healthy sample.

Abstract: A method and an apparatus for calibrating an image sensor array in a microscopic imaging system are provided. The method includes: performing a vignetting effect calibration and correction on the image sensor array, such that pixels acquired by all sub-field-of-view image sensors for capturing a scene with a same radiant exitance have a same gray level; performing a light encoding on a temporal-spatial union structure using a spatial light modulator, to establish correspondences of a plurality of feature points between an image space and a physical space; performing a light decoding on the temporal-spatial union structure, to acquire pixel coordinates of the plurality of feature points in an image plane and physical coordinates of the plurality of feature points in a plane of the spatial light modulator; acquiring a homography relationship according to the pixel coordinates and the physical coordinates, acquiring a global coordinate mapping according to the homography relationship.

Abstract: The present disclosure relates to Fourier ptychographic microscopy systems and methods. The system includes: a three-color LED array; a microscope, configured to obtain image information with multi-wavelength, and magnify to generate magnified image information; an RGB camera configured to acquire a first color image with a first resolution based on the magnified image information; and a controller, configured to synchronously control the three-color LED array and the RGB camera, in which the three-color LED array is further configured to display a plurality of illumination patterns, the RGB camera is further configured to acquire synchronously a plurality of first color images, and the controller is further configured to restore a single second image with a second resolution according to the plurality of first color images, and the first resolution is less than the second resolution. The present disclosure improves sampling speed.

Abstract: The three-dimensional microscopic imaging system includes: a microscope; a field diaphragm; a narrow-band filter, configured to perform narrow-band filtering; a beam-splitting grating, configured to duplicate a beam into beams with different angles; a lens array with different focal length, configured to perform different phase modulation to each beam with different angles; a micro lens array, configured to modulate the beams with different angles that pass through the lens array with different focal length respectively to different spatial locations at a back focal plane of the micro lens array respectively; and an image sensor configured to record an image corresponding to the modulated beams at the back focal plane of the micro lens array. The system has a simple structure, a cheap cost, and a relatively weak exciting light, and is suit for living samples, and has the adjustable intervals of imaging depths.

Abstract: A phase microscopy system and method are provided in the present disclosure. The system includes: an optical source, configured to generate collimated light; an object arrangement component, configured to provide a mask and a sample; a microscopic imaging component, including a microscope and a sensor, the microscope being configured to project light that passes successively through the mask and the sample into the sensor to capture an image; and a control component, configured to reconstruct phase information of the sample based on the image through both the sample and the mash and a pre-stored reference image of the mask, in which the pre-stored reference image is pre-acquired by the phase microscopy system without providing the sample under a same light condition. With the present disclosure, dynamic phase information of the microscopic sample can be acquired accurately and rapidly with high resolution.

Abstract: An imaging system is provided, which includes: a microscope; a field diaphragm; a one-dimensional beam-splitting grating, configured to duplicate a beam after passing through the first 4f system into beams with different angles; a phase modulation component, configured to perform different phase modulations to the beams with different angles respectively; a blazed grating, configured to perform dispersion to the beams with different angles passing through the phase modulation component at a dimension orthogonal to the beam-splitting grating; a micro lens array, configured to make the beams with different angles passing through the blazed grating to map to different locations on a back focal plane of the micro lens array; an image sensor, configured to image the back focal plane of the micro lens array. The system may recover three-dimensional information and multispectral information of the sample simultaneously from a single image.

Abstract: The present disclosure relates to a method for multi-color fluorescence imaging under a single exposure, an imaging method and system. The imaging system includes: a fluorescence microscope, configured to obtain a real image of the sample; a spatial mask, disposed behind the fluorescence microscope, and configured to perform mask modulation on the real image of the sample; a 4f system, disposed behind the spatial mask, in which the real image of the sample passes through the spatial mask to the 4f system; an optical granting, disposed on a Fourier plane in middle of the 4f system, and configured to split the real image of the sample to obtain a split real image; and an image sensor, configured to obtain the split real image to obtain an image of the sample. The present disclosure advantages of improving imaging rate in multi-spectrum fluorescence microscopy.

Abstract: A depth estimation method based on light-field data distribution includes the following steps: S1. adjusting pixel distribution of input light-field images to generate a series of refocused light-field images having different focal lengths; S2. for a spatial point, corresponding to a macro-pixel, extracting intensity ranges for the macro-pixel from the refocused light-field images, and then selecting one refocused light-field image corresponding to a minimum intensity range, the focal length of the selected refocused light-field image being taken as a scene depth of the macro-pixel; the macro-pixel corresponding to one point in an actual scene, the intensity range of the macro-pixel being a variation range of intensity values of all points within the macro-pixel; and repeating the step S2 to obtain scene depths of all macro-pixels.

Abstract: Disclosed is a method for predicting depth map coding distortion of a two-dimensional free viewpoint video, including: inputting sequences of texture maps and depth maps of two or more viewpoint stereoscopic videos; synthesizing a texture map of a first intermediate viewpoint of a current to-be-coded viewpoint and a first adjacent viewpoint, and synthesizing a texture map of a second intermediate viewpoint of the current to-be-coded viewpoint and a second adjacent viewpoint by using a view synthesis algorithm; recording a synthetic characteristic of each pixel according to the texture map and generating a distortion prediction weight; and calculating to obtain total distortion according to the synthetic characteristic and the distortion prediction weight.

Abstract: A method and a system for three-dimensionally reconstructing a non-rigid body based on a multi-depth-map are provided. The method comprises: obtaining a plurality of depth maps by shooting the non-rigid body in different postures and from different angles; transforming each depth map to one group of three-dimensional point clouds and obtaining a plurality of matching point pairs among a plurality of groups of three-dimensional point clouds; conducting a position transformation for each matching point and obtaining a transformation parameter corresponding to the each matching point after the position transformation; mosaicing all transformation parameters to obtain a mosaicing result and constructing an energy function according to the mosaicing result; and solving the energy function to obtain a solution result and reconstructing a three-dimensional model of the non-rigid body according to the solution result.

Abstract: A method and an apparatus for coded focal stack photographing are provided. The method includes: changing a focal surface within a single exposure time and per-pixel coding a sensor readout for each focal surface to obtain a modulation function M(y,z), where y?{y1,y2} is a two-dimensional spatial coordinate and z is a depth coordinate of a latent three-dimensional focal stack F(y,z); coding the latent three-dimensional focal stack F(y,z) into a two-dimensional sensor image I(y) by using the modulation function M(y,z); and achieving one or more of a programmable non-planar focal surface imaging, an interleaved focal stack imaging, and a compressive focal stack imaging, based on the modulation functions M(y,z) and the two-dimensional sensor image I(y).

Abstract: A method and an apparatus for calibrating a multi-spectral sampling system are provided. The method includes: sampling scene information of a scene to obtain a two-path multi-spectral image comprising a multi-spectral image consisting of a plurality of sampling points and a RGB color image; calibrating a spectrum of each of the plurality of sampling points to obtain a spatial location thereof and a spectral wavelength corresponding to the spatial location; providing two scanning videos in different scanning directions, demonstrating and shooting the two scanning videos to obtain two two-path multi-spectral videos, in which each two-path multi-spectral video comprises a multi-spectral video and a RGB color video; and based on the spatial location of each of the plurality of sampling points, obtaining a matching point of each of the plurality of sampling points, so as to implement a spatial location calibration of the multi-spectral sampling system.

Abstract: A method and an apparatus for calibrating a multi-spectral sampling system are provided. The method includes: sampling scene information of a scene to obtain a two-path multi-spectral image comprising a multi-spectral image consisting of a plurality of sampling points and a RGB color image; calibrating a spectrum of each of the plurality of sampling points to obtain a spatial location thereof and a spectral wavelength corresponding to the spatial location; providing two scanning videos in different scanning directions, demonstrating and shooting the two scanning videos to obtain two two-path multi-spectral videos, in which each two-path multi-spectral video comprises a multi-spectral video and a RGB color video; and based on the spatial location of each of the plurality of sampling points, obtaining a matching point of each of the plurality of sampling points, so as to implement a spatial location calibration of the multi-spectral sampling system.

Abstract: A method and a related system of free-view relighting for a dynamic scene based on photometric stereo, the method including the steps of: 1) performing multi-view dynamic videos of an object using a multi-view camera array under a predetermined controllable varying illumination; 2) obtaining a three-dimensional shape model and surface reflectance peculiarities of the object; 3) obtaining a static relighted three-dimensional model of the object and a three-dimensional trajectory of the object; 4) obtaining a dynamic relighted three-dimensional model; and 5) performing a free-view dependent rendering to the dynamic relighted three-dimensional model of the object.

Abstract: A method and a system for three-dimensionally reconstructing a non-rigid body based on a multi-depth-map are provided. The method comprises: obtaining a plurality of depth maps by shooting the non-rigid body in different postures and from different angles; transforming each depth map to one group of three-dimensional point clouds and obtaining a plurality of matching point pairs among a plurality of groups of three-dimensional point clouds; conducting a position transformation for each matching point and obtaining a transformation parameter corresponding to the each matching point after the position transformation; mosaicing all transformation parameters to obtain a mosaicing result and constructing an energy function according to the mosaicing result; and solving the energy function to obtain a solution result and reconstructing a three-dimensional model of the non-rigid body according to the solution result.

Abstract: A method and an apparatus for coded focal stack photographing are provided. The method includes: changing a focal surface within a single exposure time and per-pixel coding a sensor readout for each focal surface to obtain a modulation function M(y,z), where y ? {y1, y2} is a two-dimensional spatial coordinate and z is a depth coordinate of a latent three-dimensional focal stack F(y,z); coding the latent three-dimensional focal stack F(y,z) into a two-dimensional sensor image I(y) by using the modulation function M(y, z); and achieving one or more of a programmable non-planar focal surface imaging, an interleaved focal stack imaging, and a compressive focal stack imaging, based on the modulation functions M(y, z) and the two-dimensional sensor image I(y).