Patents by Inventor Qiu Dai
Qiu Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10738174Abstract: The present invention relates to a water-soluble polymer complex that includes a water-soluble block copolymer and a magnetic nanoparticle, wherein the water-soluble polymer complex has a nonzero net magnetic moment in the absence of an applied magnetic field at ambient temperatures. The water-soluble block copolymer is preferably a diblock or triblock copolymer and the magnetic nanoparticle is preferably a ferrimagnetic or ferromagnetic nanoparticle. The water-soluble complexes may be derivatized with reactive groups and conjugated to biomolecules. Exemplary water-soluble polymer complexes covered under the scope of the invention include PEG112-b-PAA40 modified CoFe2O4; NH2-PEG112-b-PAA40 modified CoFe2O4; PNIPAM68-b-PAA28 modified CoFe2O4; and mPEG-b-PCL-b-PAA modified CoFe2O4.Type: GrantFiled: April 23, 2012Date of Patent: August 11, 2020Assignee: International Business Machines CorporationInventors: Krishna M. Bajjuri, David Berman, Qiu Dai, Pierre-Olivier Jubert, Hareem T. Maune, Alshakim Nelson
-
Patent number: 10670592Abstract: Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.Type: GrantFiled: January 10, 2019Date of Patent: June 2, 2020Assignee: University of Central Florida Research Foundation, Inc.Inventors: Qun Huo, Xiong Liu, Qiu Dai
-
Publication number: 20190204313Abstract: Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.Type: ApplicationFiled: January 10, 2019Publication date: July 4, 2019Inventors: Qun HUO, Xiong LIU, Qiu DAI
-
Patent number: 10191041Abstract: Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.Type: GrantFiled: November 10, 2014Date of Patent: January 29, 2019Assignee: University of Central Florida Research Foundation, Inc.Inventors: Qun Huo, Xiong Liu, Qiu Dai
-
Publication number: 20160169878Abstract: Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.Type: ApplicationFiled: November 10, 2014Publication date: June 16, 2016Applicant: University of Central Florida Research Foundation, Inc.Inventors: Qun Huo, Xiong Liu, Qiu Dai
-
Patent number: 8883094Abstract: Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.Type: GrantFiled: January 5, 2009Date of Patent: November 11, 2014Assignee: University of Central Florida Research Foundation, Inc.Inventors: Qun Huo, Xiong Liu, Qiu Dai
-
Patent number: 8815610Abstract: Magnetic nanoparticles are detected across a thin membrane that separates the nanoparticles from a magnetic sensor. The technique can be used in a medical context, in which an analyte of interest (present in a test fluid, such as blood) is attached to the membrane. Other compounds are in turn bound to the analyte, with one of these compounds including a magnetic nanoparticle that is then detected by the sensor. In this way, the analyte is detected by detecting the magnetic nanoparticle. By counting the number of magnetic nanoparticles, the concentration of the analyte in the test fluid can be determined.Type: GrantFiled: October 15, 2010Date of Patent: August 26, 2014Assignee: International Business Machines CorporationInventors: David Berman, Qiu Dai, William Marvin Dyer, Wayne Isami Imaino, Alshakim Nelson
-
Publication number: 20130281623Abstract: The present invention relates to a water-soluble polymer complex that includes a water-soluble block copolymer and a magnetic nanoparticle, wherein the water-soluble polymer complex has a nonzero net magnetic moment in the absence of an applied magnetic field at ambient temperatures. The water-soluble block copolymer is preferably a diblock or triblock copolymer and the magnetic nanoparticle is preferably a ferrimagnetic or ferromagnetic nanoparticle. The water-soluble complexes may be derivatized with reactive groups and conjugated to biomolecules. Exemplary water-soluble polymer complexes covered under the scope of the invention include PEG112-b-PAA40 modified CoFe2O4; NH2-PEG112-b-PAA40 modified CoFe2O4; PNIPAM68-b-PAA28 modified CoFe2O4; and mPEG-b-PCL-b-PAA modified CoFe2O4.Type: ApplicationFiled: April 23, 2012Publication date: October 24, 2013Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Krishna M. Bajjuri, David Berman, Qiu Dai, Pierre-Olivier Jubert, Hareem T. Maune, Alshakim Nelson
-
Patent number: 8557329Abstract: Provided is a method of inhibiting magnetically induced aggregation of ferrimagnetic and/or ferromagnetic nanoparticles by encapsulating the nanoparticles in a silica shell. The method entails coating magnetic nanoparticle surfaces with a polyacid polymer to form polymer-coated magnetic nanoparticles and treating the polymer-coated magnetic nanoparticles with a silica precursor to form uniform silica-coated magnetic nanoparticles. By controlling the thickness of the silica encapsulating the nanoparticles, the inherent magnetically induced aggregation of the nanoparticles can be completely inhibited.Type: GrantFiled: May 6, 2010Date of Patent: October 15, 2013Assignee: International Business Machines CorporationInventors: Qiu Dai, Alshakim Nelson
-
Patent number: 8557943Abstract: Provided are inorganic-organic block copolymers that self assemble without the addition of a precursor. The inorganic block of the polymers includes silicon and the organic block may be any organic polymer. The inorganic-organic block copolymers self assemble to form a material in which the inorganic polymer block may be crosslinked to produce an organosilicate and/or silica matrix, and further thermal curing of the matrix results in the formation of a porous nanostructured film.Type: GrantFiled: April 29, 2011Date of Patent: October 15, 2013Assignee: International Business Machines CorporationInventors: Krishna S. Bajjuri, Qiu Dai, Alshakim Nelson, Jitendra S. Rathore
-
Publication number: 20120277339Abstract: Provided are inorganic-organic block copolymers that self assemble without the addition of a precursor. The inorganic block of the polymers includes silicon and the organic block may be any organic polymer. The inorganic-organic block copolymers self assemble to form a material in which the inorganic polymer block may be crosslinked to produce an organosilicate and/or silica matrix, and further thermal curing of the matrix results in the formation of a porous nanostructured film.Type: ApplicationFiled: April 29, 2011Publication date: November 1, 2012Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Krishna M. Bajjuri, Qiu Dai, Alshakim Nelson, Jitendra S. Rathore
-
Publication number: 20120094852Abstract: Magnetic nanoparticles are detected across a thin membrane that separates the nanoparticles from a magnetic sensor. The technique can be used in a medical context, in which an analyte of interest (present in a test fluid, such as blood) is attached to the membrane. Other compounds are in turn bound to the analyte, with one of these compounds including a magnetic nanoparticle that is then detected by the sensor. In this way, the analyte is detected by detecting the magnetic nanoparticle. By counting the number of magnetic nanoparticles, the concentration of the analyte in the test fluid can be determined.Type: ApplicationFiled: October 15, 2010Publication date: April 19, 2012Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: David Berman, Qiu Dai, William M. Dyer, Wayne I. Imaino, Alshakim Nelson
-
Publication number: 20120058548Abstract: A system for determining a presence of biomolecule targets includes a vessel holding a sample solution suspected of containing the biomolecule targets and a plurality of probes including bioreceptor functionalized metal nanoparticles including a plurality of metal atoms. The biomolecule targets when present in the sample solution bind to the plurality of probes. A separation device is for separating the plurality of probes into a first group of probes having the biomolecule targets bound thereto and a second group of probes not having the biomolecule targets bound thereto. A reagent is introduced via a port for breaking down the metal nanoparticles in the first group or second group of probes, wherein at least one signal moiety solution is formed. A device measures a parameter of the signal moiety solution.Type: ApplicationFiled: September 6, 2011Publication date: March 8, 2012Applicant: University of Central Florida Research Foundation, Inc.Inventors: QUN HUO, XIONG LIU, QIU DAI
-
Publication number: 20110274832Abstract: Provided is a method of inhibiting magnetically induced aggregation of ferrimagnetic and/or ferromagnetic nanoparticles by encapsulating the nanoparticles in a silica shell. The method entails coating magnetic nanoparticle surfaces with a polyacid polymer to form polymer-coated magnetic nanoparticles and treating the polymer-coated magnetic nanoparticles with a silica precursor to form uniform silica-coated magnetic nanoparticles. By controlling the thickness of the silica encapsulating the nanoparticles, the inherent magnetically induced aggregation of the nanoparticles can be completely inhibited.Type: ApplicationFiled: May 6, 2010Publication date: November 10, 2011Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Qiu Dai, Alshakim Nelson
-
Patent number: 8026108Abstract: An ultra sensitive method for detection of biomolecules includes the step of providing a plurality of bioreceptor functionalized nanoparticle probes. The nanoparticles can include metal, semiconductor, radioactive isotope or fluorescent dye molecules. A sample solution suspected of including the target is contacted with the probes, wherein if present, the target binds to the bioreceptor. After such binding a separating step follows. In the separating step, probes having the target bound thereto are separated from probes not having the target bound thereto. In one embodiment probes having the target bound thereto are then decomposed to generate ions, or broken into discrete radioactive isotopes or fluorescent dye molecules to form a solution including a large plurality of metal ions, radioactive isotopes or dye molecules.Type: GrantFiled: October 19, 2007Date of Patent: September 27, 2011Assignee: The University of Central Florida Research Foundation, Inc.Inventors: Qun Huo, Xiong Liu, Qiu Dai
-
Publication number: 20100285989Abstract: Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.Type: ApplicationFiled: January 5, 2009Publication date: November 11, 2010Inventors: Qun Huo, Xiong Liu, Qiu Dai