Patents by Inventor Qiulei ZHANG

Qiulei ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED INTERLEUKIN-2 (IL-2) MOLECULE AND USE THEREOF
    Publication number: 20230416326
    Abstract: A modified interleukin-2 (IL-2) molecule is obtained by being subjected to a modification as follows: substituting a region in an IL-2 molecule that mediates the binding of the IL-2 molecule to interleukin-2 receptor alpha (IL2R?) with a region in an interleukin-15 (IL-15) molecule that mediates the binding of the IL-15 molecule to interleukin-15 receptor alpha (IL15R?). The region in the IL-15 molecule that mediates the binding of the IL-15 molecule to the IL15R? includes 9 or more amino acid residues. Furthermore, a protein heterodimer including the modified IL-2 molecule and IL15R? (a Sushi domain) or a variant thereof is provided. The modified IL-2 molecule and/or the protein heterodimer including the modified IL-2 significantly reduce(s) an affinity of IL2R? to greatly reduce its side effects in clinical treatment and is promising drug candidate.
    Type: Application
    Filed: October 16, 2021
    Publication date: December 28, 2023
    Applicant: LETO LABORATORIES CO., LTD
    Inventors: Yao ZHAO, Yu ZHANG, Huijie LIU, Jinhua PIAO, Jianjun ZHANG, Qiulei ZHANG, Wei ZHANG, Guoyong WANG, Tianfu ZHANG