Abstract: This disclosure discloses inhibitors of CTGF RNA, MITF RNA, and SRD5A2 RNA and their applications, wherein the inhibitors are gene editing systems. The gene editing systems disclosed herein can knock down CTGF RNA, MITF RNA, or SRD5A2 RNA, and can be used to repair scars, whiten skin, reduce or eliminate melasma, prevent or treat melanoma, and/or prevent or treat androgenetic alopecia. This disclosure also discloses a gene editing system that targets AR RNA encoded by the androgen receptor gene, which can be used to treat androgenetic alopecia and other diseases.

Abstract: A data processing method, apparatus and device, a storage medium, and a program product are disclosed. The method may include: acquiring free-viewpoint video data, the free-viewpoint video data comprises at least one texture map and/or at least one depth map; encapsulating the at least one texture map and/or the at least one depth map in at least one media track; and processing the free-viewpoint video data according to target-viewpoint information.

Abstract: A well pattern optimization method based on CO2 incomplete miscible displacement characteristics is provided, including: obtaining fluid component data of formation crude oil, and establishing a fluid component model based on the fluid component data; establishing a three-dimensional reservoir model based on the fluid component model, and setting reservoir parameters for the three-dimensional reservoir model; performing simulation operation on the three-dimensional reservoir model with set reservoir parameters under different CO2 flooding well pattern modes, and obtaining simulation operation results; and performing analysis of fronts and production parameter comparison on the simulation operation results, and obtaining an optimal CO2 flooding well pattern mode.

Abstract: A minimum miscible pressure prediction method for a CO2-crude oil system considering reservoir well spacing is provided, including: obtaining characteristic parameters of each component of crude oil; based on the characteristic parameters of each component of the crude oil, obtaining corresponding bubble point or dew point pressures, as well as corresponding oil-gas interfacial tension, oil phase and gas phase densities, and viscosities under different injected gas contents; based on the corresponding bubble point or dew point pressures, as well as the corresponding oil-gas interfacial tension, oil phase and gas phase densities, and viscosities under different injected gas contents, constructing a minimum miscible pressure prediction model for the CO2-crude oil system considering the reservoir well spacing; and based on the minimum miscible pressure prediction model for the CO2-crude oil system considering the reservoir well spacing, obtaining minimum miscible pressure values for the CO2-crude oil system unde

Abstract: Provided are a data processing method and apparatus, a communication node, and a storage medium. The data processing method includes determining multi-frame combined point cloud information; writing the multi-frame combined point cloud information into media streams of combined point cloud data; and sending, according to the multi-frame combined point cloud information, the media streams of the combined point cloud data to a receiving end separately.

Abstract: Provided are a data transmission method, apparatus and device, and a storage medium. The data transmission method includes the following: receiving current status information sent by a client; determining status-dependent point cloud spatial region information corresponding to the current status information according to the current status information; selecting status-dependent point cloud spatial region data corresponding to the status-dependent point cloud spatial region information; and sending the status-dependent point cloud spatial region information and the status-dependent point cloud spatial region data to the client.

Abstract: Embodiments of the disclosure provide a video synthesis method, apparatus, device, medium, and product. The method includes: obtaining a region image corresponding to a target object and a background image excluding the region image by performing an image segmentation on an image frame in a video to be processed; determining a mirror image corresponding to the region image; obtaining at least one first extended image by extending the region image in a first extension direction; obtaining at least one second extended image by extending the mirror image in a second extension direction different from the first extension direction; rendering the background image, the at least one second extended image and the at least one first extended image to obtain a target rendered image at the end of the rendering; obtaining a target video corresponding to the video to be processed by performing a video synthesis on the target rendered image.

Abstract: A minimum miscible pressure prediction method for a CO2-crude oil system considering reservoir well spacing is provided, including: obtaining characteristic parameters of each component of crude oil; based on the characteristic parameters of each component of the crude oil, obtaining corresponding bubble point or dew point pressures, as well as corresponding oil-gas interfacial tension, oil phase and gas phase densities, and viscosities under different injected gas contents; based on the corresponding bubble point or dew point pressures, as well as the corresponding oil-gas interfacial tension, oil phase and gas phase densities, and viscosities under different injected gas contents, constructing a minimum miscible pressure prediction model for the CO2-crude oil system considering the reservoir well spacing; and based on the minimum miscible pressure prediction model for the CO2-crude oil system considering the reservoir well spacing, obtaining minimum miscible pressure values for the CO2-crude oil system unde

Abstract: A well pattem optimization method based on CO2 incomplete miscible displacement characteristics is provided, including: obtaining fluid component data of formation crude oil, and establishing a fluid component model based on the fluid component data; establishing a three-dimensional reservoir model based on the fluid component model, and setting reservoir parameters for the three-dimensional reservoir model; performing simulation operation on the three-dimensional reservoir model with set reservoir parameters under different CO2 flooding well pattern modes, and obtaining simulation operation results; and performing analysis of fronts and production parameter comparison on the simulation operation results, and obtaining an optimal CO2 flooding well pattern mode.

Abstract: The present invention relates to a CRISPR-Cas13 system and use thereof, and also relates to a Cas13 protein, a fusion protein, and a guide polynucleotide. The Cas13 protein has at least 90% sequence identity compared to SEQ ID NO: 1. The fusion protein comprises the Cas13 protein fused to a protein domain and/or a polypeptide tag. The guide polynucleotide comprises a same-direction repetition sequence and a guide sequence that has been engineered to hybridize with the target RNA. The same-direction repetition sequence has at least 70% sequence identity to any of SEQ ID NOs: 3 and 80-87. The CRISPR-Cas13 system comprises the Cas13 protein that has at least 90% sequence identity to SEQ ID NO: 1, or a coding nucleic acid therefor, and the guide polynucleotide or a coding nucleic acid therefor.

Abstract: A media information processing method and apparatus, a media information playback method and apparatus are disclosed. The media information processing method may include: acquiring media of a plurality of viewpoints, the plurality of viewpoints include at least one real viewpoint and at least one virtual viewpoint, and the media of the at least one virtual viewpoint is generated according to the media of the at least one real viewpoint; generating a media stream according to the media of the plurality of viewpoints, the media stream is a media file including media information; and performing segmentation and packing of the media stream, and generating a Media Presentation Description (MPD) text of the media, the MPD text includes a description of the real viewpoints and a description of the at least one virtual viewpoint, and the MPD text is used for acquiring media stream information of a viewpoint to be played.

Abstract: The present invention relates to a CRISPR-Cas13 system and use thereof, and also relates to a Cas13 protein, a fusion protein, and a guide polynucleotide. The Cas13 protein has at least 90% sequence identity compared to SEQ ID NO: 1. The fusion protein comprises the Cas13 protein fused to a protein domain and/or a polypeptide tag. The guide polynucleotide comprises a same-direction repetition sequence and a guide sequence that has been engineered to hybridize with the target RNA. The same-direction repetition sequence has at least 70% sequence identity to any of SEQ ID NOs: 3 and 80-87. The CRISPR-Cas13 system comprises the Cas13 protein that has at least 90% sequence identity to SEQ ID NO: 1, or a coding nucleic acid therefor, and the guide polynucleotide or a coding nucleic acid therefor.

Abstract: Provided are a method and apparatus for processing immersive media data, a storage medium, and an electronic apparatus. The method comprises: acquiring immersive media data corresponding to a current viewing posture of a user, wherein a three-dimensional viewing space is used to limit viewing content of the user; and rendering the immersive media data corresponding to the current viewing posture, wherein when the current viewing posture is within the three-dimensional viewing space, the acquired immersive media data is rendered; or when the current viewing posture has moved or is moving outside the three-dimensional viewing space, the immersive media data is rendered according to handling information of the three-dimensional viewing space.

Abstract: A data processing method, apparatus and device, a storage medium, and a program product are disclosed. The method may include: acquiring free-viewpoint video data, the free-viewpoint video data comprises at least one texture map and/or at least one depth map; encapsulating the at least one texture map and/or the at least one depth map in at least one media track; and processing the free-viewpoint video data according to target-viewpoint information.

Abstract: Methods, apparatus, and systems for dynamically indicating a playout group in various scenarios are disclosed. In one example aspect, a method includes determining a playout group corresponding to a volumetric video in a three-dimensional space based on a playout group information, the playout group including a plurality of components, wherein each component of a certain type has a version that is different from another component of the certain type, obtaining a two-dimensional volumetric video content from a media track corresponding to the playout group, and reconstructing the volumetric video into a three-dimensional space based on the plurality of components with different versions.

Abstract: The present invention relates to a CRISPR-Cas13 system and use thereof, and also relates to a Cas13 protein, a fusion protein, and a guide polynucleotide. The Cas13 protein has at least 90% sequence identity compared to SEQ ID NO: 1. The fusion protein comprises the Cas13 protein fused to a protein domain and/or a polypeptide tag. The guide polynucleotide comprises a same-direction repetition sequence and a guide sequence that has been engineered to hybridize with the target RNA. The same-direction repetition sequence has at least 70% sequence identity to any of SEQ ID NOs: 3 and 80-87. The CRISPR-Cas13 system comprises the Cas13 protein that has at least 90% sequence identity to SEQ ID NO: 1, or a coding nucleic acid therefor, and the guide polynucleotide or a coding nucleic acid therefor.

Abstract: Methods, apparatus, and systems that provide flexible encapsulation of volumetric video data in media files are disclosed. In one example aspect, a method for video processing includes receiving three-dimensional (3D) volumetric video data and encoding the three-dimensional volumetric video data into a media file. The 3D volumetric video data corresponds to one or more atlases, each comprising atlas data and one or more two-dimensional (2D) components. The atlas data and the one or more 2D components are stored in one or more media tracks in the media file.

Abstract: Methods, apparatus, and systems for effectively reducing media content transmissions and efficiently rendering immersive media contents are disclosed. In one example aspect, a method includes requesting, by a user, media files from a server according to the current viewing position and viewing direction of the user, receiving, by the user, the media files from the server according to the current viewing position and the viewing direction of the user, extracting a patch of an atlas, and synthesizing the visual content in the current window area of the user, and obtaining, by the user, three-dimensional stereoscopic video content according to the current viewing position and viewing direction of the user.

Abstract: Provided in embodiments of the disclosure are a media processing method, device and system, and the computer-readable storage medium. The media processing method includes: in a media file, describing position information and/or position change information of a user; and processing the media file to determine a video to be played. As such, by describing position information and/or position change information of a user in the media file, the video frame can be adjusted in real time according to the position of the user, thereby improving the quality of viewing by the user and improving user experience.

Abstract: Provided are a data processing method and apparatus, a communication node, and a storage medium. The data processing method includes determining multi-frame combined point cloud information; writing the multi-frame combined point cloud information into media streams of combined point cloud data; and sending, according to the multi-frame combined point cloud information, the media streams of the combined point cloud data to a receiving end separately.