Patents by Inventor Qiuyan Zhao

Qiuyan Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide mediated specific sytokine induction and reduction of tumor growth in a mammal
    Publication number: 20020151518
    Abstract: The invention provides new methods for modulating specific CMI-inducing cytokines in vivo. Such new methods result in stimulation of the cytokines IL-6, IL-12 MIP-1&bgr; and MCP without substantially inducing undesired cytokines. The methods according to the invention are based upon administration of oligonucleotides containing particular structural motifs which lead to specific cytokine induction.
    Type: Application
    Filed: June 12, 2002
    Publication date: October 17, 2002
    Inventors: Sudhir Agrawal, Qiuyan Zhao
  • Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
    Publication number: 20020137714
    Abstract: The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
    Type: Application
    Filed: September 26, 2001
    Publication date: September 26, 2002
    Inventors: Ekambar R. Kandimalla, Qiuyan Zhao, Dong Yu, Sudhir Agrawal
  • Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
    Patent number: 6426334
    Abstract: The invention provides new methods for modulating specific CMI-inducing cytokines in vivo. Such new methods result in stimulation of the cytokines IL-6, IL-12 MIP-1&bgr; and MCP without substantially inducing undesired cytokines. The methods according to the invention are based upon administration of oligonucleotides containing particular structural motifs which lead to specific cytokine induction.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: July 30, 2002
    Assignee: Hybridon, Inc.
    Inventors: Sudhir Agrawal, Qiuyan Zhao
  • Method of modulating gene expression with reduced immunostimulatory response
    Patent number: 5968909
    Abstract: The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by modifying at least one chemical structure within the phosphorothioate oligonucleotide to produce an immunostimulatory response-reducing phosphorothioate oligonucleotide, which is then administered to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.
    Type: Grant
    Filed: August 4, 1995
    Date of Patent: October 19, 1999
    Assignee: Hybridon, Inc.
    Inventors: Sudhir Agrawal, Jamal Temsamani, Qiuyan Zhao
  • Cyclodextrin cellular delivery system for oligonucleotides
    Patent number: 5691316
    Abstract: Disclosed is a composition including an oligonucleotide complexed with a cyclodextrin. The oligonucleotide may be noncovalently associated with the cyclodextrin. Alternatively, the oligonucleotide may be covalently complexed with adamantane which is noncovalently associated with the cyclodextrin. Also disclosed are methods of enhancing the cellular uptake and intracellular concentration of oligonucleotides, methods of increasing the solubility of an oligonucleotide in a cell, and methods of treating a cell for viral infection or to prevent viral infection.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: November 25, 1997
    Assignee: Hybridon, Inc.
    Inventors: Sudhir Agrawal, Qiuyan Zhao, Ivan Habus
  • Cyclodextrin cellular delivery system for oligonucleotides
    Patent number: 5616565
    Abstract: Disclosed is a composition including an oligonucleotide complexed with a cyclodextrin. The oligonucleotide may be noncovalently associated with the cyclodextrin. Alternatively, the oligonucleotide may be covalently complexed with adamantane which is noncovalently associated with the cyclodextrin. Also disclosed are methods of enhancing the cellular uptake and intracellular concentration of oligonucleotides, methods of increasing the solubility of an oligonucleotide in a cell, and methods of treating a cell for viral infection or to prevent viral infection.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 1, 1997
    Assignee: Hybridon, Inc.
    Inventors: Sudhir Agrawal, Qiuyan Zhao, Ivan Habus
  • Cyclodextrin cellular delivery system for oligonucleotides
    Patent number: 5605890
    Abstract: Disclosed is a composition including an oligonucleotide complexed with a cyclodextrin. The oligonucleotide may be noncovalently associated with the cyclodextrin. Alternatively, the oligonucleotide may be covalently complexed with adamantane which is noncovalently associated with the cyclodextrin. Also disclosed are methods of enhancing the cellular uptake and intracellular concentration of oligonucleotides, methods of increasing the solubility of an oligonucleotide in a cell, and methods of treating a cell for viral infection or to prevent viral infection.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 25, 1997
    Assignee: Hybridon, Inc.
    Inventors: Sudhir Agrawal, Qiuyan Zhao, Ivan Habus